Investigation of top mass measurements with the ATLAS detector at LHC

Several methods for the determination of the mass of the top quark with the ATLAS detector at the LHC are presented. All dominant decay channels of the top quark can be explored. The measurements are in most cases dominated by systematic uncertainties. New methods have been developed to control those related to the detector. The results indicate that a total error on the top mass at the level of 1 GeV should be achievable.Comment: 47 pages, 40 figure

A 5-W GaN Doherty Amplifier for Ka-Band Satellite Downlink With 4-GHz Bandwidth and 17-dB NPR

This letter presents the design and experimental characterization of a GaN-Si monolithic Doherty power amplifier (PA) for the Ka-band satellite downlink. The fabricated amplifier favorably compares with the current state of the art, achieving from 16.3 to 20.3 GHz (4 GHz, 22% relative bandwidth), a record band to date, 36.6-37.7-dBm output power, 23%-31% power-added efficiency, 18-22-dB gain at saturation, and around 20% power-added efficiency at 6-dB output back-off. At 18.8 GHz, the amplifier shows a noise-to-power ratio higher than 17 dB at all power levels, making it suitable for satellite applications where additional linearization is usually unfeasible

Investigation and Numerical Simulation of a High-Current AC Circuit Breaker

The article is devoted to the study of the high-current AC circuit breaker. The results of the study are presented for various configurations of the arc divider. The study includes methods of spectral diagnostics and high-speed camera shooting synchronized with the electrical characteristics of the circuit breaker (current, voltage) in time. The obtained results allow to determine the composition of the plasma and dynamics of changes in the composition of the discharge in time. Calculation of the plasma composition and properties is made according to the obtained data, which makes it possible to take into account the products of circuit breaker materials ablation in numerical simulation. Non-stationary two-dimensional mathematical model with a moving mesh is developed. The obtained results allow to correct and verify the developed mathematical model of the circuit breaker operation. The evaluation of the arc divider influence is presented in the article

Allergen-Specific Antibodies Regulate Secondary Allergen-Specific Immune Responses

Immunoglobulin E (IgE)-associated allergy is the most common immunologically-mediated hypersensensitivity disease. It is based on the production of IgE antibodies and T cell responses against per se innocuous antigens (i.e., allergens) and subsequent allergen-induced inflammation in genetically pre-disposed individuals. While allergen exposure in sensitized subjects mainly boosts IgE production and T cell activation, successful allergen-specific immunotherapy (AIT) induces the production of allergen-specific IgG antibodies and reduces T cell activity. Under both circumstances, the resulting allergen-antibody complexes play a major role in modulating secondary allergen-specific immune responses: Allergen-IgE complexes induce mast cell and basophil activation and perpetuate allergen-specific T cell responses via presentation of allergen by allergen presenting cells to T cells, a process called IgE-facilitated antigen presentation (FAP). In addition, they may induce activation of IgE memory B cells. Allergen-induced production of specific IgGs usually exerts ameliorating effects but under certain circumstances may also contribute to exacerbation. Allergen-specific IgG antibodies induced by AIT which compete with IgE for allergen binding (i.e., blocking IgG) inhibit formation of IgE-allergen complexes and reduce activation of effector cells, B cells and indirectly T cells as FAP is prevented. Experimental data provide evidence that by binding of allergen-specific IgG to epitopes different from those recognized by IgE, allergen-specific IgG may enhance IgE-mediated activation of mast cells, basophils and allergen-specific IgE+ B cells. In this review we provide an overview about the role of allergen-specific antibodies in regulating secondary allergen-specific immune responses

Vacancy-mediated dopant diffusion activation enthalpies for germanium

Electronic structure calculations are used to predict the activation enthalpies of diffusion for a range of impurity atoms (aluminium, gallium, indium, silicon, tin, phosphorus, arsenic, and antimony) in germanium. Consistent with experimental studies, all the impurity atoms considered diffuse via their interaction with vacancies. Overall, the calculated diffusion activation enthalpies are in good agreement with the experimental results, with the exception of indium, where the most recent experimental study suggests a significantly higher activation enthalpy. Here, we predict that indium diffuses with an activation enthalpy of 2.79 eV, essentially the same as the value determined by early radiotracer studies

Feasibility of low-dose coronary CT angiography: first experience with prospective ECG-gating

AIMS: To determine the feasibility of prospective electrocardiogram (ECG)-gating to achieve low-dose computed tomography coronary angiography (CTCA). METHODS AND RESULTS: Forty-one consecutive patients with suspected (n = 35) or known coronary artery disease (n = 6) underwent 64-slice CTCA using prospective ECG-gating. Individual radiation dose exposure was estimated from the dose-length product. Two independent readers semi-quantitatively assessed the overall image quality on a five-point scale and measured vessel attenuation in each coronary segment. One patient was excluded for atrial fibrillation. Mean effective radiation dose was 2.1 +/- 0.6 mSv (range, 1.1-3.0 mSv). Image quality was inversely related to heart rate (HR) (57.3 +/- 6.2, range 39-66 b.p.m.; r = 0.58, P 63 b.p.m. (P < 0.001). CONCLUSION: This first experience documents the feasibility of prospective ECG-gating for CTCA with diagnostic image quality at a low radiation dose (1.1-3.0 mSv), favouring HR <63 b.p.