Ti-Zr-Si-Nb nanocrystalline alloys and metallic glasses: Assessment on the structure, thermal stability, corrosion and mechanical properties

The development of novel Ti-based amorphous or \u3b2-phase nanostructured metallic materials could have significant benefits for implant applications, due to improved corrosion and mechanical characteristics (lower Young's modulus, better wear performance, improved fracture toughness) in comparison to the standardized \u3b1+\u3b2 titanium alloys. Moreover, the devitrification phenomenon, occurring during heating, could contribute to lower input power during additive manufacturing technologies. Ti-based alloy ribbons were obtained by melt-spinning, considering the ultra-fast cooling rates this method can provide. The titanium alloys contain in various proportions Zr, Nb, and Si (Ti60Zr10Si15Nb15, Ti64Zr10Si15Nb11, Ti56Zr10Si15Nb19) in various proportions. These elements were chosen due to their reported biological safety, as in the case of Zr and Nb, and the metallic glass-forming ability and biocompatibility of Si. The morphology and chemical composition were analyzed by scanning electron microscopy and energy-dispersive X-ray spectroscopy, while the structural features (crystallinity, phase attribution after devitrification (after heat treatment)) were assessed by X-ray diffraction. Some of the mechanical properties (hardness, Young's modulus) were assessed by instrumented indentation. The thermal stability and crystallization temperatures were measured by differential thermal analysis. High-intensity exothermal peaks were observed during heating of melt-spun ribbons. The corrosion behavior was assessed by electrocorrosion tests. The results show the potential of these alloys to be used as materials for biomedical applications

NeuBtracker-imaging neurobehavioral dynamics in freely behaving fish.

A long-standing objective in neuroscience has been to image distributed neuronal activity in freely behaving animals. Here we introduce NeuBtracker, a tracking microscope for simultaneous imaging of neuronal activity and behavior of freely swimming fluorescent reporter fish. We showcase the value of NeuBtracker for screening neurostimulants with respect to their combined neuronal and behavioral effects and for determining spontaneous and stimulus-induced spatiotemporal patterns of neuronal activation during naturalistic behavior

Hydatidosis of the central nervous system in central and Eastern Europe

Hydatidosis (also known as echinococcosis or hydatid disease) is one of Europe's neglected infections of poverty. Cystic echinococcosis (CE) is endemic in Southwestern and Eastern parts of Europe. Although alveolar echinococcosis was considered a rare disease in Central Europe, recent studies have shown its emerging nature and demonstrated that the endemic areas for this parasite are broader than previously thought. This chapter aims not only to review but also to bring to light new epidemiological and clinical data regarding hydatidosis of the central nervous system (CNS) in the countries of Eastern and Central Europe where information was available. At the same time, we intend to shed light on particular or interesting cases reported in the literature. Special emphasis will be given to the casuistic from Romania, listed in 1995 among the countries with the highest prevalence of CE worldwide and where, in the past, at least one person from 45.5 % of its localities underwent surgery for CE. Although rare in Central and Eastern Europe, hydatidosis of the CNS should always be considered in the differential diagnosis of any patient with seizures, focal neurological deficits, and symptoms of increased intracranial pressure, especially when that person comes from regions with high disease prevalence