Human repetitive sequence densities are mostly negatively correlated with R/Y-based nucleosome-positioning motifs and positively correlated with W/S-based motifs

AbstractWe examined statistical correlations between the frequencies of seven proposed nucleosome positioning motifs and the densities of repetitive sequences in the human genome. For both parametric and non-parametric measures of statistical correlations there is a tendency for repetitive sequence density to be negatively correlated with the density of R/Y-based nucleosome positioning motifs, while being positively correlated with that of W/S-based motifs. These results largely hold even when motifs are examined only within repeat-filtered sequences. The RRRRRYYYYY motif and its 5-base shift YYYYYRRRRR, in particular, is over-represented in the human genome; and its negative correlation is consistently present at different regions and at different length scales. For some other nucleosome positioning motifs, the relationship with repeats can be regional or length scale dependent. Considering the importance of nucleosome formation in epigenetic regulations, these results may provide new insight to the evolution of repetitive sequences

Introduction: Examined Live – An Epistemological Exchange Between Philosophy and Cultural Psychology on Reflection

Besides the general agreement about the human capability of reflection, there is a large area of disagreement and debate about the nature and value of “reflective scrutiny” and the role of “second-order states” in everyday life. This problem has been discussed in a vast and heterogeneous literature about topics such as epistemic injustice, epistemic norms, agency, understanding, meta-cognition etc. However, there is not yet any extensive and interdisciplinary work, specifically focused on the topic of the epistemic value of reflection. This volume is one of the first attempts aimed at providing an innovative contribution, an exchange between philosophy, epistemology and psychology about the place and value of reflection in everyday life. Our goal in the next sections is not to offer an exhaustive overview of recent work on epistemic reflection, nor to mimic all of the contributions made by the chapters in this volume. We will try to highlight some topics that have motivated a new resumption of this field and, with that, drawing on chapters from this volume where relevant. Two elements defined the scope and content of this volume, on the one hand, the crucial contribution of Ernest Sosa, whose works provide original and thought-provoking contributions to contemporary epistemology in setting a new direction for old dilemmas about the nature and value of knowledge, giving a central place to reflection. On the other hand, the recent developments of cultural psychology, in the version of the “Aalborg approach”, reconsider the object and scope of psychological sciences, stressing that “[h]uman conduct is purposeful”

A refined sin hyperbolic shear deformation theory for sandwich FG plates by enhanced meshfree with new correlation function

The moving Kriging interpolation-based (MKI) meshfree method is extended to mechanical behavior analysis of isotropic and sandwich functionally graded material plates. The MKI meshfree method, which is free of shear correction factors effect in plate analysis, is further enhanced by introducing a new multi-quadric correlation function, eliminating drawbacks of its conventional form, gaining accurate solution. In this paper, a new refined sin hyperbolic shear deformation plate theory (N-RSHSDT) is introduced for plate kinematics. The present theory gives rise to four governing equations only, and achieves the sin hyperbolic distribution of the transverse shear strains through the plate thickness. To show the accuracy and effectiveness of the developed method, numerical experiments are performed for both isotropic and sandwich composite plates

Unsteady shock front waviness in shock-buffet of transonic aircraft

The unsteady transonic aerodynamics of a wing-body configuration is investigated by solving the Unsteady Reynolds-averaged Navier-Stokes equations closed with the full Reynolds Stress Model. This work presents the prediction of flow field characteristics during deep shock-buffet penetration of a transport aircraft-representative geometry. Mach number of 0.85, and Reynolds number of 5 million based on the mean chord, are selected to reproduce experimental test conditions that serve as validating datasets. The results obtained give information about both surface and flow field shock-buffet dynamics. An unsteady shock front is observed on the suction side of the wing which gives birth to the so-called buffet cells. Flow field characteristics are dominated by the presence of lambda-shaped shocks and fully separated boundary layer over a significant part of the wing

OPORTUNIDADES DE CONSERVACIÓN DEL BOSQUE DE NIEBLA A TRAVÉS DEL MANEJO ALTERNATIVO: LOS AGROECOSISTEMAS CAFETALEROS

In México, the distribution of cloud forest or mountain mesophyll forest (MMF) coincides with that of shade-grown coffee (Coffea arabica L.) production. In this study, we discuss the way in which agroforestry coffee systems (ACS) can help MMF conservation, considering them as reservoirs of biodiversity, environmental services for the forest that the ACS displaced, fostering the regeneration potential; they are also a source of productive diversification that increases regional social welfare and therefore decreases the pressure on the MMF remnants. The productive diversification is exemplified with the research-action lines: use of timber-yielding native trees and exploitation of epiphytes in rustic nurseriesEn México, la distribución del bosque de niebla o bosque mesófilo de montaña (BMM) coincide con la del cultivo de café (Coffea arabica L.) bajo sombra. En este trabajo, se discute cómo los sistemas agroforestales en café (SAF) pueden ayudar a la conservación del BMM considerándolos como reservorios de biodiversidad, servicios ambientales hacia el bosque que los SAF desplazaron fomentando el potencial de regeneración; así como fuente de diversificación productiva que incrementan el bienestar social regional y por tanto disminuyen la presión sobre los remanentes del BMM. La diversificación productiva se ejemplifica con las líneas de investigación-acción: uso de árboles nativos maderables y aprovechamiento de epifitas en viveros rústicos

Activity of nitrifying bacteria and productivity of crops under the use of green manure

During the recycling of soil nitrogen, it is necessary to register the activity of nitrifying bacteria in nitrification. This process, in tropical conditions, is negatively affected by extreme variations in temperature, humidity, pH and organic matter during agronomic practices. Population changes of nitrifying bacteria in corn and soybean crops were evaluated under the use and management of green manure (GM). It was established as GM Mucuna pruriens var. utilis (CIAT No. 9349) - corn var. ICA 305. Ninety days later it was harvested and the residues were incorporated as LF or disposed on the soil surface as organic mulch (OM), the native weed Rottboellia cochinchinensis L. was managed as fallow (F). Then, corn-soybean crops were sown in an intercalated and monoculture system, each system was subject to organic fertilization (OF), chemical fertilization (CF) or no fertilization (NF). 11 treatments were structured under the design of Random Complete Blocks with 32 + 2 factorial arrangements with three repetitions. In the stage of blossoming and grain filling of the crops, the variables analyzed were; oxidizing bacteria of ammonium nitrate, volumetric humidity, temperature and yield. The populations of AOB and the production of NO3- did not vary significantly between treatments, but it did occur with soil temperature and humidity. The use of GM / OM promoted yields similar to those obtained with CF in corn, while in soybeans, when OM was added, yields exceeded CF

Effects of Crab Cavity Multipoles on JLEIC Ion Ring Dynamic Aperature

We study the effects of crab cavity multipole fields on the beam dynamic aperture of the Jefferson Lab Electron-Ion Collider (JLEIC) ion ring. Crab cavities are needed to compensate for luminosity loss due to a 50 mrad crossing angle at the interaction point. New compact crab cavity designs are interesting as they do not require considerable space in the ring but their non-linear field needs to be well understood. In this contribution, we study the impact of field multipoles on the beam dynamic aperture and report tolerance values for crab cavity multipoles