541 research outputs found

    How psychological dispositions influence the theology of the afterlife

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    Humans across cultures have formulated rich views about what happens after death, including reincarnationist beliefs and beliefs in an afterlife. Theologians further develop and elaborate these views. Recent work in the cognitive science of religion suggests that afterlife beliefs are caused by psychological dispositions that are a stable part of human cognition. For instance, humans intuitively conceptualize themselves and others as composed of material and nonmaterial parts, which facilitates the idea that physical death is not the end of personhood. In this paper, we explore how psychological dispositions influence theological views of the afterlife, focusing on Mormon theology

    Study of cavernous underground conduits in Nam La (Northwest Vietnam) by an integrative approach

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    This paper presents the result of an investigation of underground conduits, which connect the swallow holes and the resurgence of a blind river in the tropical, highly karstified limestone Nam La catchment in the NW of Vietnam. The Nam La River disappears underground in several swallow holes near the outlet of the catchment. In the rainy season this results in flooding upstream of the sinkholes. A hypothesis is that the Nam La River resurges at a large cavern spring 4.5 km east of the catchment outlet. A multi-thematic study of the possible connections between the swallow holes and the resurgence was carried out to investigate the geological structure, tectonics, cave structure analysis and discharge time series. The existence of the underground conduits was also tested and proven by tracer experiments. On the basis of a lineament analysis the location of the underground conduits were predicted. A remote sensing derived lineament-length density map was used to track routes from the swallow holes to the resurgence, having the shortest length but highest lineament density. This resulted in a plan-view prediction of underground conduits that matches with the cave and fault development. The functioning of the conduits was further explained by analysing flooding records of a nearby doline, which turns out to act as a temporary storage reservoir mitigating flooding of the catchment outlet area

    A mathematical model for the development of mealiness in apples

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    Mealiness in apples (Malus domestica Borkh.) is an internal quality defect which is characterised by a dry and crumbly texture. It is related to the relative strength of the cell wall and the middle lamella. A mathematical model has been built to relate changes in the texture attributes juiciness, tensile strength and hardness, which are associated with mealiness, to the development of the turgor pressure of the tissue and the degree of hydrolysis of the middle lamella. The latter, in turn, are described in terms of properties which are meaningful from the physiological point of view, such as starch content, soluble solids content, non-hydrolysed and hydrolysed middle lamella, water in the symplast, and water in the apoplast. Biochemical reactions as well as water transfer processes are incorporated in the model. The parameter values of the model are estimated using experimental data from a storage experiment. The model fits the three texture characteristics adequately. The correlation coefficients between the parameters were below 0.96, which indicates that the model does not overfit the data

    Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor

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    The anti-apoptotic Bcl-2 protein is the founding member and namesake of the Bcl-2-protein family. It has recently been demonstrated that Bcl-2, apart from its anti-apoptotic role at mitochondrial membranes, can also directly interact with the inositol 1,4,5-trisphosphate receptor (IP3R), the primary Ca2+-release channel in the endoplasmic reticulum (ER). Bcl-2 can thereby reduce pro-apoptotic IP3R-mediated Ca2+ release from the ER. Moreover, the Bcl-2 homology domain 4 (Bcl-2-BH4) has been identified as essential and sufficient for this IP3R-mediated anti-apoptotic activity. In the present study, we investigated whether the reported inhibitory effect of a Bcl-2-BH4 peptide on the IP (3)R1 was related to the distinctive alpha-helical conformation of the BH4 domain peptide. We therefore designed a peptide with two glycine "hinges" replacing residues I14 and V15, of the wild-type Bcl-2-BH4 domain (Bcl-2-BH4-IV/GG). By comparing the structural and functional properties of the Bcl-2-BH4-IV/GG peptide with its native counterpart, we found that the variant contained reduced alpha-helicity, neither bound nor inhibited the IP (3)R1 channel, and in turn lost its anti-apoptotic effect. Similar results were obtained with other substitutions in Bcl-2-BH4 that destabilized the alpha-helix with concomitant loss of IP3R inhibition. These results provide new insights for the further development of Bcl-2-BH4-derived peptides as specific inhibitors of the IP3R with significant pharmacological implications

    Emotional responses to fiction: an evolutionary perspective

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    Across cultures, humans create fictional worlds. Storytelling is a cross-cultural phenomenon, taking various forms, such as narrative dances that act out passages of the Ramayana and Mahabharata, Latin American telenovelas, recitations by West African griots (troubadours) accompanied by a kora (twenty-one-string lute), and intricate Russian novels. Narratives elicit emotions. Many authors have proposed comprehensive theories about what emotions are, and how they could be categorized. Darwin (1872) was the first to propose an evolutionary, functional explanation for emotions: they help to prepare an animal for appropriate actions and to effectively communicate inner states, such as distress or anger, to others. Emotions elicited by fiction, and by art more broadly, do not fit neatly in these evolutionary scenarios. To understand the role of emotions in fiction, it is important to look at the motivations of both authors and consumers. Social novels highlight problematic social circumstances, such as extreme poverty, slavery, or animal cruelty

    Comparison between sensorial and instrumental measurements for mealiness assessment in apples

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    Definition and establishment of assessment procedures for mealiness of apple fruits using sensory and instrumental measurements were performed on ‘Boskoop', ‘Cox's Orange Pippin’ and ‘Jonagold’ samples with varying degrees of mealiness. The sensory procedure profiled mealiness as a loss of crispness, hardness, and juiciness, with an increase in the floury sensation in the mouth. High correlations between the sensory descriptors and instrumental parameters was shown through principal component analysis. The instrumental procedures (confined compression of fruit cylinders and acoustic impulse response) gave coefficients of determination for juiciness and crispness of 0.85 and 0.71, respectively. This level of accuracy indicates the possibility of establishin

    Ergodicity criteria for non-expanding transformations of 2-adic spheres

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    In the paper, we obtain necessary and sufficient conditions for ergodicity (with respect to the normalized Haar measure) of discrete dynamical systems on 2-adic spheres S2r(a)\mathbf S_{2^{-r}}(a) of radius 2r2^{-r}, r1r\ge 1, centered at some point aa from the ultrametric space of 2-adic integers Z2\mathbb Z_2. The map f ⁣:Z2Z2f\colon\mathbb Z_2\to\mathbb Z_2 is assumed to be non-expanding and measure-preserving; that is, ff satisfies a Lipschitz condition with a constant 1 with respect to the 2-adic metric, and ff preserves a natural probability measure on Z2\mathbb Z_2, the Haar measure μ2\mu_2 on Z2\mathbb Z_2 which is normalized so that μ2(Z2)=1\mu_2(\mathbb Z_2)=1

    Self-consistent equation for an interacting Bose gas

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    We consider interacting Bose gas in thermal equilibrium assuming a positive and bounded pair potential V(r)V(r) such that 0<\int d\br V(r) = a<\infty. Expressing the partition function by the Feynman-Kac functional integral yields a classical-like polymer representation of the quantum gas. With Mayer graph summation techniques, we demonstrate the existence of a self-consistent relation ρ(μ)=F(μaρ(μ))\rho (\mu)=F(\mu-a\rho(\mu)) between the density ρ\rho and the chemical potential μ\mu, valid in the range of convergence of Mayer series. The function FF is equal to the sum of all rooted multiply connected graphs. Using Kac's scaling V_{\gamma}(\br)=\gamma^{3}V(\gamma r) we prove that in the mean-field limit γ0\gamma\to 0 only tree diagrams contribute and function FF reduces to the free gas density. We also investigate how to extend the validity of the self-consistent relation beyond the convergence radius of Mayer series (vicinity of Bose-Einstein condensation) and study dominant corrections to mean field. At lowest order, the form of function FF is shown to depend on single polymer partition function for which we derive lower and upper bounds and on the resummation of ring diagrams which can be analytically performed.Comment: 33 pages, 6 figures, submitted to Phys.Rev.
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