15 research outputs found
Effect of Operational Parameters on the Behavior of Phosphorus and Sulfur in Aluminum Reduction
No full textWiley Online librar
Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice
No full textAccumulation of 8-Oxoguanine in Liver DNA During Hyperoxic Resuscitation of Newborn Mice
No full textEndonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia
No full textNeural stem/progenitor cell proliferation and differentiation are required to replace damaged neurons and regain brain function after hypoxic-ischemic events. DNA base lesions accumulating during hypoxic-ischemic stress are removed by DNA glycosylases in the base-excision repair pathway to prevent cytotoxicity and mutagenesis. Expression of the DNA glycosylase endonuclease VIII-like 3 (Neil3) is confined to regenerative subregions in the embryonic and perinatal brains. Here we show profound neuropathology in Neil3-knockout mice characterized by a reduced number of microglia and loss of proliferating neuronal progenitors in the striatum after hypoxia-ischemia. In vitro expansion of Neil3-deficient neural stem/progenitor cells revealed an inability to augment neurogenesis and a reduced capacity to repair for oxidative base lesions in single-stranded DNA. We propose that Neil3 exercises a highly specialized function through accurate molecular repair of DNA in rapidly proliferating cells
Three related brain nuclear receptors, NGFI-B, Nurr1, and NOR-1, as transcriptional activators
No full textAge estimation by measuring maxillary canine pulp/tooth volume ratio on cone beam CT images with two different voxel sizes
No full textImprovement of oxidized glutathione fermentation by thiol redox metabolism engineering in Saccharomyces cerevisiae
No full text
