NNLO Corrections to the Polarized Drell-Yan Coefficient Function

We present the full next-to-next-to-leading order (NNLO) corrections to the coefficient function for the polarized cross section $d \Delta\sigma/d Q$ of the Drell-Yan process. We study the effect of these corrections on the process $p+p\to l^+l^-+`X'$ at an C.M. energy $\sqrt{S}=200 GeV$. All QCD partonic subprocesses have been included provided the lepton pair is created by a virtual photon, which is a valid approximation for a lepton pair invariant mass $Q<50 GeV$. For this reaction the dominant subprocess is given by $q+\bar q\to \gamma^*+`X'$ and its higher order corrections so that it provides us with an excellent tool to measure the polarized sea-quark densities.Comment: 5 pages, 5 figures, 7th DESY Workshop on Elementary Particle Theory, Loops and Legs in Quantum Field Theory, Zinnowitz, Germany, April 25-30, 200

Clinical outcomes of Single-Visit oral Prophylaxis: A practice-based randomised controlled trial

Peer reviewedPublisher PD

Exploring what lies behind public preferences for avoiding health losses caused by lapses in healthcare safety and patient lifestyle choices

© 2013 Singh et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.This article has been made available through the Brunel Open Access Publishing Fund.Background: Although many studies have identified public preferences for prioritising health care interventions based on characteristics of recipient or care, very few of them have examined the reasons for the stated preferences. We conducted an on-line person trade-off (PTO) study (N=1030) to investigate whether the public attach a premium to the avoidance of ill health associated with alternative types of responsibilities: lapses in healthcare safety, those caused by individual action or lifestyle choice; or genetic conditions. We found that the public gave higher priority to prevention of harm in a hospital setting such as preventing hospital associated infections than genetic disorder but drug administration errors were valued similar to genetic disorders. Prevention of staff injuries, lifestyle diseases and sports injuries, were given lower priority. In this paper we aim to understand the reasoning behind the responses by analysing comments provided by respondents to the PTO questions. Method: A majority of the respondents who participated in the survey provided brief comments explaining preferences in free text responses following PTO questions. This qualitative data was transformed into explicit codes conveying similar meanings. An overall coding framework was developed and a reliability test was carried out. Recurrent patterns were identified in each preference group. Comments which challenged the assumptions of hypothetical scenarios were also investigated. Results: NHS causation of illness and a duty of care were the most cited reasons to prioritise lapses in healthcare safety. Personal responsibility dominated responses for lifestyle related contexts, and many respondents mentioned that health loss was the result of the individual’s choice to engage in risky behaviour. A small proportion of responses questioned the assumptions underlying the PTO questions. However excluding these from the main analysis did not affect the conclusions. Conclusion: Although some responses indicated misunderstanding or rejection of assumptions we put forward, the results were still robust. The reasons put forward for responses differed between comparisons but responsibility was the most frequently cited. Most preference elicitation studies only focus on eliciting numerical valuations but allowing for qualitative data can augment understanding of preferences as well as verifying results.EPSRC through the MATCH programme(EP/F063822/1 and EP/G012393/1) and HERG within Brunel University

Quark Orbital-Angular-Momentum Distribution in the Nucleon

We introduce gauge-invariant quark and gluon angular momentum distributions after making a generalization of the angular momentum density operators. From the quark angular momentum distribution, we define the gauge-invariant and leading-twist quark {\it orbital} angular momentum distribution $L_q(x)$. The latter can be extracted from data on the polarized and unpolarized quark distributions and the off-forward distribution $E(x)$ in the forward limit. We comment upon the evolution equations obeyed by this as well as other orbital distributions considered in the literature.Comment: 8 pages, latex, no figures, minor corrections mad

Next-to-leading Order Evolution of Transversity Distributions and Soffer's Inequality

We present a calculation of the two-loop splitting functions for the evolution of the twist-2 `transversity' parton densities of transversely polarized nucleons. We study the implications of our results for Soffer's inequality for the case of valence quark densities.Comment: 23 Pages, LaTeX, 2 figures as eps files, final, slightly modified version, to appear in Phys. Rev.

Drell-Yan forward-backward and spin asymmetries for arbitrary vector boson production at next-to-leading order

Longitudinally polarized, unpolarized and forward-backward mass differential cross sections for Drell-Yan lepton-pair production by arbitrary vector bosons are calculated in next-to-leading order (NLO) QCD. Analytical results are presented in a form valid for all consistent $n$-dimensional regularization schemes, with the mass factorization scheme kept general. NLO predictions for all Drell-Yan type processes ($W^\pm$, $Z$ and $\gamma^*$) at BNL's relativistic heavy ion collider (RHIC) are made using polarized parton distributions which fit the recent deep-inelastic scattering data. These are examined as tools in the determination of the polarized parton distributions and the unpolarized $\bar{u}/\bar{d}$ ratio. NLO predictions for the forward-backward lepton asymmetry at Fermilab are made and the precision determination of $\sin^2 \theta_W$ from future runs is studied. In all the above, the QCD corrections are found to be significant. An introductory discussion is given of various theoretical issues, such as allowable factorization and regularization schemes, and scale dependences.Comment: 34 pages, figures included, revtex. Some discussions and references added/modified. In more compact form. To appear in Phys. Rev.

Orbital Angular Momentum Parton Distributions in Light-Front Dynamics

We study the quark angular momentum distribution in the nucleon within a light-front covariant quark model. Special emphasis is put into the orbital angular momentum: a quantity which is very sensitive to the relativistic treatment of the spin in a light-front dynamical approach. Discrepancies with the predictions of the low-energy traditional quark models where relativistic spin effects are neglected, are visible also after perturbative evolution to higher momentum scales. Orbital angular momentum distributions and their contribution to the spin sum rule are calculated for different phenomenological mass operators and compared with the results of the MIT bag model.Comment: 14 pages; latex; 3 ps figure

Trigonometry of spacetimes: a new self-dual approach to a curvature/signature (in)dependent trigonometry

A new method to obtain trigonometry for the real spaces of constant curvature and metric of any (even degenerate) signature is presented. The method encapsulates trigonometry for all these spaces into a single basic trigonometric group equation. This brings to its logical end the idea of an absolute trigonometry, and provides equations which hold true for the nine two-dimensional spaces of constant curvature and any signature. This family of spaces includes both relativistic and non-relativistic homogeneous spacetimes; therefore a complete discussion of trigonometry in the six de Sitter, minkowskian, Newton--Hooke and galilean spacetimes follow as particular instances of the general approach. Any equation previously known for the three classical riemannian spaces also has a version for the remaining six spacetimes; in most cases these equations are new. Distinctive traits of the method are universality and self-duality: every equation is meaningful for the nine spaces at once, and displays explicitly invariance under a duality transformation relating the nine spaces. The derivation of the single basic trigonometric equation at group level, its translation to a set of equations (cosine, sine and dual cosine laws) and the natural apparition of angular and lateral excesses, area and coarea are explicitly discussed in detail. The exposition also aims to introduce the main ideas of this direct group theoretical way to trigonometry, and may well provide a path to systematically study trigonometry for any homogeneous symmetric space.Comment: 51 pages, LaTe

ProCAID: a phase I clinical trial to combine the AKT inhibitor AZD5363 with docetaxel and prednisolone chemotherapy for metastatic castration resistant prostate cancer.

Background Docetaxel and prednisolone chemotherapy (DP) extends survival in metastatic castration resistant prostate cancer (mCRPC). However, emergent clinical resistance is almost inevitable. AKT pathway activation is highly prevalent in mCRPC contributing to disease progression and DP resistance. AZD5363 is a potent oral pan-AKT inhibitor with pre-clinical data indicating activity in mCRPC and synergy with docetaxel. Methods This phase I trial was to determine an AZD5363 recommended phase II dose (RP2D) for combination with DP. Eligibility criteria included chemotherapy naive mCRPC, PSA or radiographic disease progression and ECOG performance status 0 or 1. Treatment comprised DP (75 mg/m2, IV, day 1 and 5 mg BID, PO, day 1-21 respectively for ten cycles) and AZD5363 to disease progression for all patients. We utilised a 3 + 3 dose escalation design to determine a maximum tolerated dose according to defined dose limiting toxicity criteria assessed using CTCAE version 4.03. Planned AZD5363 dose levels were 320 mg (DL1), 400 mg (DL2) and 480 mg (DL3), BID, PO, 4 days on/3 days off, from day 2 of each cycle. Results 10 patients were treated. Dose limiting toxicities affected 2 patients (grade 3 rash ≥5 days; grade 3 diarrhoea) in DL2. The commonest grade 3 or 4, AZD5363 related, symptomatic adverse events were rash and diarrhoea. Hyperglycaemia affected all patients but was self-limiting. PSA reduction to <50% at 12 weeks occurred in 7 patients. Conclusions The RP2D for AZD5363 is 320 mg BID, 4 days on/3 days off, in combination with full dose DP for mCRPC

Threat-sensitive anti-predator defence in precocial wader, the northern lapwing Vanellus vanellus

Birds exhibit various forms of anti-predator behaviours to avoid reproductive failure, with mobbing—observation, approach and usually harassment of a predator—being one of the most commonly observed. Here, we investigate patterns of temporal variation in the mobbing response exhibited by a precocial species, the northern lapwing (Vanellus vanellus). We test whether brood age and self-reliance, or the perceived risk posed by various predators, affect mobbing response of lapwings. We quantified aggressive interactions between lapwings and their natural avian predators and used generalized additive models to test how timing and predator species identity are related to the mobbing response of lapwings. Lapwings diversified mobbing response within the breeding season and depending on predator species. Raven Corvus corax, hooded crow Corvus cornix and harriers evoked the strongest response, while common buzzard Buteo buteo, white stork Ciconia ciconia, black-headed gull Chroicocephalus ridibundus and rook Corvus frugilegus were less frequently attacked. Lapwings increased their mobbing response against raven, common buzzard, white stork and rook throughout the breeding season, while defence against hooded crow, harriers and black-headed gull did not exhibit clear temporal patterns. Mobbing behaviour of lapwings apparently constitutes a flexible anti-predator strategy. The anti-predator response depends on predator species, which may suggest that lapwings distinguish between predator types and match mobbing response to the perceived hazard at different stages of the breeding cycle. We conclude that a single species may exhibit various patterns of temporal variation in anti-predator defence, which may correspond with various hypotheses derived from parental investment theory