HETEROSIS STUDIES IN HYBRID RICE (ORYZA SATIVA L.) OVER LOCATIONS

The present study was carried out to investigate the extent of standard heterosis and to identify promising hybrids with high magnitude of heterosis for yield and yield contributing traits. Fifty two hybrids were generated in line × tester mating fashion and evaluated in randomized block design along with parents and checks over locations. The assessment of heterosis showed significant results for all the traits.  Eighteen hybrids exhibited significant standard heterosis for grain yield plant-1 and top among them were APMS 6A × MTU II-110-9-1-1-1-1, APMS 10A × MTU II-290-42-1 and APMS 9A × MTU II-143-26-2. These hybrids  were also found significantly positive standard heterosis for  yield components like number of panicle bearing  tillers plant-1,  panicle length, number of filled grains panicle-1 and test weight.  The above top performing hybrids may be used for commercial exploitation

Synthesis and Bioassay of Azolyl Benzothiazine Carboxamides

Cyclic sulfonamides (sultams) gained importance due to their potential pharmaceutical activity. Amongst these, 1,2-benzothiazine-1,1-dioxide and their derivatives represent the most familiar class of non-steroidal anti-inflammatory drugs (NSAIDs) available in the market. In fact, Meloxicam and Piroxicam, the members of oxicam family are used as an analgesic and anti-inflammatory drugs. Azoles are potential chemical entities with a wide range of pharmacological activities such as anticancer, antibacterial, antifungal, antiviral and antiparasitic. In continuation of our efforts to develop potential multifunctional heterocycles, we have synthesized novel azolylbenzothiazine carboxamides and studied their cytotoxic and antioxidant activities. The results of these aspects will be discussed. © 2020 Author(s).The authors Venkatapuram Padmavathi and Panga Siva Sankar are grateful to CSIR (Council of Scientific and Industrial Research), New Delhi for financial assistance under the major research project

Synthesis of Carboxamide and Sulfonyl Carboxamide Linked Azoles Under Green Conditions

Direct coupling of heteroaldehydes with heteroaryl amines/sulfonylamines is performed under green conditions using PEG-400 in the presence of oxidant CCl3CN/H2O2. The presence of electron-withdrawing substituents on heteroaldehydes increased the yield. Further heteroaryl amines favor the reaction when compared with heteroaryl sulfonylamines. © 2020 Author(s).One of the authors G. Lakshmi Teja is indebted to the University Grants Commission (UGC), New Delhi for sanction of UGC-BSR fellowship

PRIVACY PRESERVING POLICY UPDATE FOR BIG DATA ACCESS CONTROL IN THE CLOUD COMPUTING

Big data majorly associated with  the high volume and velocity , it is an effective option to store big data in the cloud, as the cloud has capabilities of storing big data and processing high volume of user access requests. Attribute-Based Encryption (ABE) is a promising technique to ensure the end-to-end security of big data in the cloud. However, the policy updating has always been a challenging issue when ABE is used to construct access control schemes. A trivial implementation is to let data owners retrieve the data and re-encrypt it under the new access policy, and then send it back to the cloud. This method, however, incurs a high communication overhead and heavy computation burden on data owners. A novel scheme is proposed that enable efficient access control with dynamic policy updating for big data in the cloud. Developing an outsourced policy updating method for ABE systems is focused. This method can avoid the transmission of encrypted data and minimize the computation work of data owners, by making use of the previously encrypted data with old access policies. Policy updating algorithms is proposed for different types of access policies. An efficient and secure method is proposed that allows data owner to check whether the cloud server has updated the ciphertexts correctly. The analysis shows that this policy updating outsourcing scheme is correct, complete, secure and efficient

Synthesis of Heteroaryl Urea Derivatives as Antimicrobial Agents

Azoles are prominent scaffolds in the pharmaceutical arena. In fact, medicinal properties of azole and benzazole containing compounds include anticancer, antimicrobial and antioxidant. Some of the drugs Inthomycin C, Oxaprozin, Tiazofurin, Dacarbazine, Tipifarnib, Albendazole, Febendazole, Omeprazole possess azole/benzazole moiety. Realizing the importance of azoles and benzazoles, it is planned to conjugate these two ligands as heteroaryl substituted urea derivatives and to study their antimicrobial activity. The results pertaining to these aspects will be discussed. © 2020 Author(s).The authors K. Narendra Babu and V. Padmavathi are grateful to CSIR (Council of Scientific and Industrial Research), New Delhi for financial assistance under major research project

Antidiabetic activity of Manomani chooranam aqueous extract on female wistar albino rats

Background: The aim of the present study was to evaluate the antidiabetic potential of Manomani chooranam (MMC), an indigenous polyherbal siddha formulation in Streptozotocin (STZ) induced diabetic female Wistar albino rats.Methods: Aqueous extract of MMC was prepared. Wistar albino rats were divided into six groups (n=6). Group 1 was kept as normal control, Group 2, 3, 4, 5 and 6 were induced diabetes. After induction, the group 2 was kept as diabetes control; Group 3 received the standard drug metformin (100 mg/kg), whereas Groups 4, 5 and 6 were treated with the aqueous extract of MMC at 500 mg/kg, 1000 mg/kg and 1250 mg/kg doses, respectively for the 21 days. Blood sugar was estimated at the end of each week. At the end of the study, rats were sacrificed and the pancreas was analyzed for histopathological changes. Data expressed as mean±standard error of the mean. Statistical analysis was done using one-way ANOVA followed by post hoc Tukey's test. p<0.05 considered statistically significant.Results: The groups which received aqueous extract of MMC at 500 mg/kg, 1000 mg/kg and 1250 mg/kg showed a significant decrease in the mean blood sugar level when compared to normal level. The groups which received MMC shows significant reduction in blood sugar level in comparison with standard drug metformin 100 mg/kg.Conclusions: The aqueous extract of MMC was able to decrease the elevated blood sugar levels in dose dependent manner

Preparation of some 5,7-diarylcyclohexeno[3,4-d]-l-selena-2,3-diazolyl-6- spiro-5'-(2',3'-pyrazolidine / 2',3'-oxazolidine)-l ',4'-diones and 5,7-diarylcyclohexeno[3,4-d]-1-thia-2,3-diazolyl-6-spiro-5'(2',3'-pyrazolidine/2',3'-oxazolidine )-1',4'-diones

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Analysis of Stability and G × E Interaction of Rice Genotypes across Saline and Alkaline Environments in India

Genotype × environment (G × E) interaction effects are of special interest for identifying the most suitable genotypes with respect to target environments, representative locations and other specific stresses. Twenty-two advanced breeding lines contributed by the national partners of the Salinity Tolerance Breeding Network (STBN) along with four checks were evaluated across 12 different salt affected sites comprising five coastal saline and seven alkaline environments in India. The study was conducted to assess the G × E interaction and stability of advanced breeding lines for yield and yield components using additive main effects and multiplicative interaction (AMMI) model. In the AMMI1 biplot, there were two mega-environments (ME) includes ME-A as CARI, KARAIKAL, TRICHY and NDUAT with winning genotype CSR 2K 262; and ME-B as KARSO, LUCKN, KARSA, GOA, CRRI, DRR, BIHAR and PANVE with winning genotypes CSR 36. Genotypes CSR 2K 262, CSR 27, NDRK 11-4, NDRK 11-3, NDRK 11-2, CSR 2K 255 and PNL 1-1-1-6-7-1 were identified as specifically adapted to favorable locations. The stability and adaptability of AMMI indicated that the best yielding genotypes were CSR 2K 262 for both coastal saline and alkaline environments and CSR 36 for alkaline environment. CARI and PANVEL were found as the most discernible environments for genotypic performance because of the greatest GE interaction. The genotype CSR 36 is specifically adapted to coastal saline environments GOA, KARSO, DRR, CRRI and BIHAR and while genotype CSR 2K 262 adapted to alkaline environments LUCKN, NDUAT, TRICH and KARAI. Use of most adapted lines could be used directly as varieties. Using them as donors for wide or specific adaptability with selection in the target environment offers the best opportunity for widening the genetic base of coastal salinity and alkalinity stress tolerance and development of adapted genotypes. Highly stable genotypes can improve the rice productivity in salt-affected areas and ensure livelihood of the resource poor farming communities

2,6-Diaryl pyridinium cation-A precursor in the cleavage process of 5,7-diarylpiperidino[ [3,4-d]-l,2,3-selenadiazolesl thiadiazoles

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