98 research outputs found
L-NAME-induced preeclampsia: correction of functional disorders of the hemostasis system with resveratrol and nicorandil
Preeclampsia is a formidable disease of the second half of pregnancy, leading to severe complications, including disability and even death. Many authors have recognized the correlation between the severity of preeclampsia and the degree of disturbances in the hemostasis system. In this regard, the objective of this study was to assess inhibition of platelet aggregation and the possibility of its correction with resverΠ°trol and nicorand
The effect of arginase ii selective inhibitors on the functional parameters of experimental animals in ADMAβlike preeclampsia
Perinatal mortality rate and the rate of preterm birth (10-12%) in pregnant women with hypertensive disorders far outweigh the corresponding values in women with physiological pregnancy. Despite such close attention worldwide to this problem, today the number of this complication has no tendency to decreas
ΠΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΠΉ Π²ΠΊΠ»Π°Π΄ ΡΠ΅Π΄ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠΈ Π² Π±ΠΈΠ±Π»ΠΈΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π½Π°ΡΡΠ½ΠΎΠ³ΠΎ ΠΆΡΡΠ½Π°Π»Π° (ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΠΎ-Π±ΠΈΠ±Π»ΠΈΠΎΡΠ΅ΡΠ½Π°Ρ ΠΎΠ±Π»Π°ΡΡΡ)
The authors attempt to determine publishing contribution of editorial board members (EBM) into the rating of their parent journals as exemplified by Russian journals in library and information sciences divided into low-, middle-, and top-rank groups. To determine this contribution, we studied EBM scholarly input to their parent journals vs. to other sources; besides, the scholarly input by EBM and other authors in each journal was compared. No correlation between the journal rank and share of EBMβs publications in their parent journals and/or EBMβs citations of their journal, or correlation between the journal rank and share of EBM papers in the respective journal were detected. However, the positive correlation was revealed between the journal rank and share of foreign EBM, regardless of their scholarly input in their parent journal. The analysis of citation of EBM papers in their journals, as well as the analyses of their journal citations provided by EBM in other sources, demonstrates significant impact of EBM on bibliometric indices of top- and low-rank journals implying active involvement of EBM in the development of their parent serials. The lowest or even negative impact of EBM on journal rank was identified among the middle-rank group of journals since their papers were poorly (if ever) cited. Thus, formal inclusion of experts into editorial boards of those journals and low interest they take in their journal may be assumed. Our findings contribute to scientometric studies of editorial boards and may be of interest to editors-in-chief and founders of journals.Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΠΏΡΠΈΠ½ΡΡΠ° ΠΏΠΎΠΏΡΡΠΊΠ° ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΠΉ Π²ΠΊΠ»Π°Π΄ ΡΠ΅Π΄Π°ΠΊΡΠΈΠΎΠ½Π½ΡΡ
ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠΉ Π² ΡΠ΅ΠΉΡΠΈΠ½Π³ΠΎΠ²ΡΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΆΡΡΠ½Π°Π»ΠΎΠ² Π½Π° ΠΏΡΠΈΠΌΠ΅ΡΠ΅ ΡΠΎΡΡΠΈΠΉΡΠΊΠΈΡ
ΠΈΠ·Π΄Π°Π½ΠΈΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΠΎ-Π±ΠΈΠ±Π»ΠΈΠΎΡΠ΅ΡΠ½ΠΎΠΉ ΡΠ΅ΠΌΠ°ΡΠΈΠΊΠΈ, ΡΠ°Π·Π΄Π΅Π»ΡΠ½Π½ΡΡ
Π½Π° ΡΡΠΈ Π³ΡΡΠΏΠΏΡ β Ρ Π½Π΅Π²ΡΡΠΎΠΊΠΈΠΌ ΡΠ΅ΠΉΡΠΈΠ½Π³ΠΎΠΌ, ΡΡΠ΅Π΄Π½Π΅Π³ΠΎ ΡΡΠΎΠ²Π½Ρ ΠΈ Π²ΡΡΠΎΠΊΠΎΠ°Π²ΡΠΎΡΠΈΡΠ΅ΡΠ½ΡΠ΅. ΠΠ»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π΄ΠΎΠ»Π΅Π²ΠΎΠ³ΠΎ Π²ΠΊΠ»Π°Π΄Π° Π² ΠΊΠ°ΠΆΠ΄ΠΎΠΉ ΠΈΠ· Π³ΡΡΠΏΠΏ ΠΆΡΡΠ½Π°Π»ΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈΡΡ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ ΡΠ»Π΅Π½ΠΎΠ² ΡΠ΅Π΄ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠΈ Π² ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΆΡΡΠ½Π°Π»Π°Ρ
ΠΈ Π² Π΄ΡΡΠ³ΠΈΡ
ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠ°Ρ
; ΠΏΡΠΎΠ²Π΅Π΄ΡΠ½ ΡΡΠ°Π²Π½ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΏΠΎΡΠΎΠΊΠ° ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ ΡΠ΅Π΄ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠΈ Π² ΡΠ²ΠΎΠΈΡ
ΠΆΡΡΠ½Π°Π»Π°Ρ
Ρ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΡΠΌΠΈ ΠΏΡΠΎΡΠΈΡ
Π°Π²ΡΠΎΡΠΎΠ². ΠΠ΅ Π±ΡΠ»ΠΎ Π²ΡΡΠ²Π»Π΅Π½ΠΎ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ΅ΠΉΡΠΈΠ½Π³ΠΎΠΌ ΠΆΡΡΠ½Π°Π»Π° ΠΈ Π΄ΠΎΠ»Π΅ΠΉ ΠΏΡΠ±Π»ΠΈΠΊΡΡΡΠΈΡ
ΡΡ Π² ΠΆΡΡΠ½Π°Π»Π΅ ΠΈ (ΠΈΠ»ΠΈ) ΡΠΈΡΠΈΡΡΡΡΠΈΡ
ΡΠ²ΠΎΠΉ ΠΆΡΡΠ½Π°Π» ΡΡΠ°ΡΡΠ½ΠΈΠΊΠΎΠ² ΡΠ΅Π΄ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ Π΄ΠΎΠ»Π΅ΠΉ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ ΡΠ΅Π΄ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠΈ Π² ΡΠ²ΠΎΡΠΌ ΠΆΡΡΠ½Π°Π»Π΅. Π ΡΠΎ ΠΆΠ΅ Π²ΡΠ΅ΠΌΡ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π° ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ΅ΠΉΡΠΈΠ½Π³ΠΎΠΌ ΠΆΡΡΠ½Π°Π»Π° ΠΈ Π΄ΠΎΠ»Π΅ΠΉ Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΡΡ
ΡΡΠ°ΡΡΠ½ΠΈΠΊΠΎΠ² ΡΠ΅Π΄ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠΈ Π²Π½Π΅ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΈΡ
ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ Π²ΠΊΠ»Π°Π΄Π° Π² ΠΆΡΡΠ½Π°Π». ΠΠ½Π°Π»ΠΈΠ· ΡΠΈΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ ΡΠ΅Π΄ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠΈ Π² ΡΠ²ΠΎΡΠΌ ΠΆΡΡΠ½Π°Π»Π΅, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠΈΡΠΈΡΠΎΠ²Π°Π½ΠΈΠΉ, ΡΠ΄Π΅Π»Π°Π½Π½ΡΡ
ΡΠ΅Π΄ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠ΅ΠΉ Π½Π° ΡΠ²ΠΎΠΉ ΠΆΡΡΠ½Π°Π» Π² Π΄ΡΡΠ³ΠΈΡ
ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠ°Ρ
, ΠΏΠΎΠΊΠ°Π·Π°Π» Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΡΠ΅Π΄ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠΈ Π½Π° ΡΠ΅ΠΉΡΠΈΠ½Π³ Π²ΡΡΠΎΠΊΠΎΠ°Π²ΡΠΎΡΠΈΡΠ΅ΡΠ½ΡΡ
ΠΆΡΡΠ½Π°Π»ΠΎΠ² ΠΈ ΠΆΡΡΠ½Π°Π»ΠΎΠ² Ρ Π½ΠΈΠ·ΠΊΠΈΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ. Π ΡΡΠΎΠΌ ΠΏΡΠΎΡΠ»Π΅ΠΆΠΈΠ²Π°Π΅ΡΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΡΡΠ°ΡΡΠΈΠ΅ ΡΠ΅Π΄ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠΉ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΈΠ·Π΄Π°Π½ΠΈΠΉ. ΠΠ°ΠΈΠΌΠ΅Π½ΡΡΠ΅Π΅, Π° Π² ΡΡΠ΄Π΅ ΡΠ»ΡΡΠ°Π΅Π² ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΡΠ΅ΠΉΡΠΈΠ½Π³ ΠΆΡΡΠ½Π°Π»ΠΎΠ² ΠΎΠΊΠ°Π·Π°Π»ΠΈ ΠΌΠ°Π»ΠΎΠΈΠ»ΠΈ Π½Π΅ΡΠΈΡΠΈΡΡΠ΅ΠΌΡΠ΅ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ ΡΠ»Π΅Π½ΠΎΠ² ΡΠ΅Π΄ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠΈ Π² ΠΆΡΡΠ½Π°Π»Π°Ρ
ΡΡΠ΅Π΄Π½Π΅ΠΉ Π³ΡΡΠΏΠΏΡ, ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡΠΈΠ΅, Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ, ΠΎ ΡΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠΌ ΠΏΡΠΈΠ²Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΡΡΡΠ½ΡΡ
Π² ΡΠ΅Π΄ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠΈ ΠΈ ΠΈΡ
Π½Π΅Π·Π°ΠΈΠ½ΡΠ΅ΡΠ΅ΡΠΎΠ²Π°Π½Π½ΠΎΡΡΠΈ Π² ΡΠ°Π±ΠΎΡΠ΅. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π²Π½ΠΎΡΡΡ Π²ΠΊΠ»Π°Π΄ Π² Π½Π°ΡΠΊΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ΅Π΄Π°ΠΊΡΠΈΠΎΠ½Π½ΡΡ
ΠΊΠΎΠ»Π»Π΅Π³ΠΈΠΉ ΠΈ ΠΌΠΎΠ³ΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ Π΄Π»Ρ Π³Π»Π°Π²Π½ΡΡ
ΡΠ΅Π΄Π°ΠΊΡΠΎΡΠΎΠ² ΠΈ ΡΡΡΠ΅Π΄ΠΈΡΠ΅Π»Π΅ΠΉ ΠΆΡΡΠ½Π°Π»ΠΎΠ²
Perfection of the mechanism of planning of innovative activities based on the system-transdisciplinary approach
The possibility of applying transdisciplinary system methodology in the process of developing plans for the innovative development of business entities has been considered. The use of a transdisciplinary systematic approach to innovation planning allows you to use new methodological planning tools, strengthen the systematic nature of planned activities, more clearly define their content and sequence.Various variants of the classification of scientific approaches according to the criterion of the degree of completeness of cognition of the surrounding world have been analysed, the basic transdisciplinary methodological approaches according to the content criteria and possibilities have been compared, such as: the theory of autopoiesis, the theory of chaos and complexity, the theory of fractals, the theory of turbulence and the theory of economic genetics.An important factor in the proposed methodology is the use of the evolutionary property of the development of organizational systems in combination with the possibility of revolutionary transformations at certain stages of development that determine the susceptibility of the organizational system to innovations. In the process of planning innovations, it is only possible to take into account these features of the development of organizational systems using a systemic transdisciplinary methodology.In the process of research, a transdisciplinary tool such as multiplex has been proposed for use, allowing us to determine the duration of the βinternalβ periods of development of the organizational system and, consequently, increase the validity of planned measures for the implementation of innovations. The use of this tool in the planning process has allowed us to find an approach to determining the duration of the periods of the various stages of the innovation process, which can in future provide an opportunity to effectively distribute the resources of an economic entity over time. At the same time, special attention in the process of planning investments in the innovation process has been paid to the practice of venture and business angel financing, the positive performance of which has been proved by the example of the United States
Static conductivity of charged domain wall in uniaxial ferroelectric-semiconductors
Using Landau-Ginzburg-Devonshire theory we calculated numerically the static
conductivity of both inclined and counter domain walls in the uniaxial
ferroelectrics-semiconductors of n-type. We used the effective mass
approximation for the electron and holes density of states, which is valid at
arbitrary distance from the domain wall. Due to the electrons accumulation, the
static conductivity drastically increases at the inclined head-to-head wall by
1 order of magnitude for small incline angles theta pi/40 by up 3 orders of
magnitude for the counter domain wall (theta=pi/2). Two separate regions of the
space charge accumulation exist across an inclined tail-to-tail wall: the thin
region in the immediate vicinity of the wall with accumulated mobile holes and
the much wider region with ionized donors. The conductivity across the
tail-to-tail wall is at least an order of magnitude smaller than the one of the
head-to-head wall due to the low mobility of holes, which are improper carries.
The results are in qualitative agreement with recent experimental data for
LiNbO3 doped with MgO.Comment: 20 pages, 6 figures, 1 appendi
Genotypic variability of Pinus sylvestris L. on the drought-resistance attribute
There was an increase and intensification of droughts in connection with global climate change in recent decades. Not all plant organisms are able to adapt to changing environmental conditions. Therefore, the question of stressresistant (drought-resistant) genotypes selection for breeding is quite urgent. This problem also concerns forest tree plants, including Scots pine, which is one of the main foresters in the Voronezh region. The results of vegetative and generative sphere analysis of individual Scotch pine trees with the help of biotechnology, molecular-genetic and cytogenetic method are given in this study. The possibility of applying the tissue culture method in vitro for testing initial plants for stress resistance, including drought resistance, is explained by the interconnection of cells, tissues and the whole plant properties. It is shown that the cytogenetic characteristics of the seed progeny and the indicators of callusogenic reactions do not always coincide in different genotypes: in some cases energy resources are spent on ontogeny protection, while, in other cases, to reproductive function maintain. There are trees, in which the state the generative sphere in arid years is at the level of optimal years, and their callus cultures reaction remains unchanged even under simulated conditions of drought. Based on the results obtained for the selection of Scots pine drought-resistant genotypes we suggest applying a system of criteria characterizing both the ability of theΒ vegetative sphere to survive in drought conditions on the basis of the tissue culture method in vitro (callus tissue formation speed, its viability, frequency of callusogenesis), and the state of the generative sphere with the help of cytogenetic analysis of seed progeny (frequency of mitosis pathologies, the proportion of cells with micronuclei, mitotic activity). The expediency of applying the biotechnological approach was proved by analysis of the gene expression level of stress proteins: the level of AbaH gene expression correlates greatly with the indicator of the viability of callus cultures, including ones on a nutrient medium with an additional stress agent (NaCl). Trees that can be assigned to drought-resistant ones, according to the results of the analysis, should be recommended for use in breeding
Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction
This paper is
about a way of correction of endothelial
dysfunction with the inhibitor of
arginase: L-norvaline. There is an
imbalance between vasoconstriction and
vasodilatation factors of endothelium on the basis
of endothelial dysfunction. Among vasodilatation
agents, nitrogen oxide plays the basic role.
Amino acid L-arginine serves as a source of molecules of nitrogen oxide in an
organism. Because of the high activity of arginase enzyme which
catalyzes the hydrolysis of L-arginine into
ornithine and urea, the bioavailability of
nitrogen oxide decreases. The inhibitors of
arginase suppress the activity of the given enzyme,
raising and production of nitrogen oxide, preventing
the development of endothelial
dysfunction
ΠΡΠΈΡΠ΅ΡΠΈΠΈ Π°Π²ΡΠΎΡΡΡΠ²Π° ΠΈ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ° Π΅Π³ΠΎ Π°ΡΡΠΈΠ±ΡΡΠΈΠΈ Π² Π½Π°ΡΡΠ½ΡΡ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΡΡ
A complication of academic research, the emergence of new subject areas at the intersection of different scientific disciplines, increase in international collaboration are accompanied by an increase in the number of co-authors resulting in the problem of author attribution requiring the development of new approaches to detecting authorsβ roles and formation of new authorship criteria. The solution of the problem of authorship attribution should specify actual contribution of the scientist to preparing research and the paper, distinguish areas of responsibility of co-authors, and enable certain researchers to accumulate their own reputation capital. The current study presents a review of Russian and foreign approaches for solving this problem including the development of new sections in articles for naming persons who do not match authorship criteria and introduction of models of sequence order of authors. The paper also traces the main stages in the development of authorship criteria, describes the advantages and disadvantages of authorship model as compared to new contributorship model. Transition to the fractional calculation of the contribution of each participant of a research paper is believed to be promising implying significance of the authorβs position in the byline and an increased role of paper sections describing the specific contribution of each author.Π£ΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠ΅ Π½Π°ΡΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΏΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ Π½ΠΎΠ²ΡΡ
ΠΎΠ±Π»Π°ΡΡΠ΅ΠΉ Π½Π° ΡΡΡΠΊΠ°Ρ
ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
Π΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½, ΡΠ°ΡΡΠΈΡΠ΅Π½ΠΈΠ΅ ΠΌΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠΎΡΡΡΠ΄Π½ΠΈΡΠ΅ΡΡΠ²Π° ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΡΡ ΡΠΎΡΡΡ ΡΠΈΡΠ»Π° Π°Π²ΡΠΎΡΠΎΠ² Π² ΡΠ°ΡΡΡΡΠ΅ Π½Π° Π½Π°ΡΡΠ½ΡΡ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ ΡΠΈΡΠ»Π° ΡΠΎΠ°Π²ΡΠΎΡΠΎΠ². ΠΡΠΎ Π²Π΅Π΄ΡΡ ΠΊ ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅ Π°ΡΡΠΈΠ±ΡΡΠΈΠΈ Π°Π²ΡΠΎΡΡΡΠ²Π°, ΡΡΠ΅Π±ΡΡΡΠ΅ΠΉ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠΈ Π½ΠΎΠ²ΡΡ
ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π°Π²ΡΠΎΡΡΠΊΠΈΡ
ΡΠΎΠ»Π΅ΠΉ ΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π½ΠΎΠ²ΡΡ
ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅Π² Π°Π²ΡΠΎΡΡΡΠ²Π°. Π Π΅ΡΠ΅Π½ΠΈΠ΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ Π°ΡΡΠΈΠ±ΡΡΠΈΠΈ Π°Π²ΡΠΎΡΡΡΠ²Π° ΠΏΡΠΈΠ·Π²Π°Π½ΠΎ ΡΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠΉ Π²ΠΊΠ»Π°Π΄ ΡΡΡΠ½ΠΎΠ³ΠΎ Π² ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΈ ΡΡΠ°ΡΡΠΈ ΠΏΠΎ Π΅Π³ΠΎ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ°ΠΌ, ΡΠ°Π·Π³ΡΠ°Π½ΠΈΡΠΈΡΡ Π·ΠΎΠ½Ρ ΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎΡΡΠΈ ΡΠΎΠ°Π²ΡΠΎΡΠΎΠ², ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡΡ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΠΌ ΡΡΡΠ½ΡΠΌ Π½Π°ΠΊΠ°ΠΏΠ»ΠΈΠ²Π°ΡΡ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΠΉ ΡΠ΅ΠΏΡΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΉ ΠΊΠ°ΠΏΠΈΡΠ°Π». Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ ΠΎΠ±Π·ΠΎΡ ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΡΡ
ΠΈ Π·Π°ΡΡΠ±Π΅ΠΆΠ½ΡΡ
ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΎΠ±ΠΎΠ·Π½Π°ΡΠ΅Π½Π½ΠΎΠΉ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ, Π²ΠΊΠ»ΡΡΠ°Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½ΠΎΠ²ΡΡ
ΡΠ°Π·Π΄Π΅Π»ΠΎΠ² ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ Π΄Π»Ρ ΡΠΊΠ°Π·Π°Π½ΠΈΡ Π»ΠΈΡ, Π½Π΅ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΡ
ΠΊΡΠΈΡΠ΅ΡΠΈΡΠΌ Π°Π²ΡΠΎΡΡΡΠ²Π°, ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΡ ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ ΡΠΏΠΎΡΡΠ΄ΠΎΡΠ΅Π½ΠΈΡ ΠΈΠΌΡΠ½ Π°Π²ΡΠΎΡΠΎΠ². ΠΡΠΎΡΠ»Π΅ΠΆΠ΅Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΡΡΠ°ΠΏΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅Π² Π°Π²ΡΠΎΡΡΡΠ²Π°, ΠΎΡΡΠ°ΠΆΠ΅Π½Ρ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΈ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΊΠΈ ΠΌΠΎΠ΄Π΅Π»ΠΈ Π°Π²ΡΠΎΡΡΡΠ²Π° ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ ΠΏΡΠΎΡΠΈΠ²ΠΎΠΏΠΎΡΡΠ°Π²Π»Π΅Π½ΠΈΡ Π½ΠΎΠ²ΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΎΠΏΠΈΡΠ°Π½ΠΈΡ Π²ΠΈΠ΄ΠΎΠ² ΡΡΠ°ΡΡΠΈΡ Π² Π½Π°ΡΡΠ½ΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ. ΠΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅ΡΡΡ ΠΏΠ΅ΡΠ΅Ρ
ΠΎΠ΄ ΠΊ ΡΡΠ°ΠΊΡΠΈΠΎΠ½Π½ΠΎΠΌΡ ΡΡΡΡΡ Π²ΠΊΠ»Π°Π΄Π° ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ ΠΈΠ· ΡΠΎΠ·Π΄Π°ΡΠ΅Π»Π΅ΠΉ Π½Π°ΡΡΠ½ΠΎΠ³ΠΎ ΠΏΡΠΎΠΈΠ·Π²Π΅Π΄Π΅Π½ΠΈΡ, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΠΎΠΌ Π²ΠΎΠ·ΡΠ°ΡΡΠ°Π΅Ρ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΏΠΎΠ·ΠΈΡΠΈΠΈ Π°Π²ΡΠΎΡΠΎΠ² Π² Π°Π²ΡΠΎΡΡΠΊΠΎΠΉ ΡΡΡΠΎΠΊΠ΅ ΠΈ ΡΡΠΈΠ»ΠΈΠ²Π°Π΅ΡΡΡ ΡΠΎΠ»Ρ ΡΠ°Π·Π΄Π΅Π»ΠΎΠ² ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΈ Ρ ΠΊΠΎΠ½ΠΊΡΠ΅ΡΠ½ΡΠΌ ΠΎΠΏΠΈΡΠ°Π½ΠΈΠ΅ΠΌ Π°Π²ΡΠΎΡΡΠΊΠΎΠ³ΠΎ Π²ΠΊΠ»Π°Π΄Π°
Π€Π΅Π½ΠΎΠΌΠ΅Π½ Π½Π°ΡΡΠ½ΠΎΠΉ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ Π² ΠΈΠ½ΡΠΎΡΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΡ
In the last few years, scientific mobility phenomenon has attracted greater attention of some researchers working in different subject areas due to the increased significance of migration of scientists in the new context of computerization, globalization of science, and an increase in the number of cross- and multidisciplinary studies. This paper briefly describes the main stages of scientific mobility in the 20th and 21st centuries closely related to different types of mobility including the concepts of brain drain and brain gain, brain circulation, and new types of brain networking and synchronous mobility. We also summarized and typed the main approaches developed by researchers when studying scientific mobility. Particular focus was on the subject for studies on mobility with main clusters covering motivations and driving forces, the impact of mobility on research output, pathways of research migration, connections between scientific mobility and research collaborations, and development of approaches to study scientific mobility. It was revealed that most common methods include analysis of curriculum vitae, interviewing and questionnaire surveys, and scientometric methods. Finally, we addressed currently unsolved problems when studying scientific mobility.Π ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΠ΅ Π³ΠΎΠ΄Ρ ΡΠ΅Π½ΠΎΠΌΠ΅Π½ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΡΡΡΠ½ΡΡ
ΠΏΡΠΈΠ²Π»Π΅ΠΊΠ°Π΅Ρ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΎΠ±Π»Π°ΡΡΡΡ
Π·Π½Π°Π½ΠΈΠΉ, ΡΡΠΎ Π²ΡΠ·Π²Π°Π½ΠΎ Π²ΠΎΠ·ΡΠΎΡΡΠΈΠΌΠΈ ΠΏΠΎΡΠΎΠΊΠ°ΠΌΠΈ Π½Π°ΡΡΠ½ΠΎΠΉ ΠΌΠΈΠ³ΡΠ°ΡΠΈΠΈ, ΠΏΡΠΎΡΠ΅ΡΡΠ°ΠΌΠΈ Π³Π»ΠΎΠ±Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ, Π·Π°ΡΡΠΎΠ½ΡΠ²ΡΠΈΠΌΠΈ Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Π½Π°ΡΡΠ½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΠΈΡΠ»Π° ΠΌΠ΅ΠΆΠ΄ΠΈΡΡΠΈΠΏΠ»ΠΈΠ½Π°ΡΠ½ΡΡ
ΠΈ ΠΏΠΎΠ»ΠΈΡΠ΅ΠΌΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°Π±ΠΎΡ. Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΡΡΠ°ΠΏΡ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΡΡΡΠ½ΡΡ
Π² XXβXXIΒ Π²Π²., ΡΠ΅ΡΠ½ΡΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ ΡΠ²ΡΠ·Π°Π½Π½ΡΠ΅ Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ ΡΠΈΠΏΠ°ΠΌΠΈ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ, Π²ΠΊΠ»ΡΡΠ°Ρ ΡΡΠ΅ΡΠΊΡ, ΠΏΡΠΈΡΠΎΠΊ ΠΈ ΡΠΈΡΠΊΡΠ»ΡΡΠΈΡ ΡΠΌΠΎΠ², Π° ΡΠ°ΠΊΠΆΠ΅ Π½ΠΎΠ²ΡΠ΅ ΡΠΈΠΏΡ ΡΠ΅ΡΠ΅Π²ΠΎΠΉ ΠΈ ΡΠΈΠ½Ρ
ΡΠΎΠ½Π½ΠΎΠΉ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ. ΠΠ°Π½Π° ΡΠΈΠΏΠΎΠ»ΠΎΠ³ΠΈΡ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π²ΡΠΈΡ
ΡΡ Π½Π° ΡΠ΅Π³ΠΎΠ΄Π½ΡΡΠ½ΠΈΠΉ Π΄Π΅Π½Ρ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΡΡΡΠ½ΡΡ
. ΠΡΠ΄Π΅Π»ΡΠ½ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠ΄Π΅Π»Π΅Π½ΠΎ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡΠΌ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΡΡΡΠ½ΡΡ
, Π²ΠΊΠ»ΡΡΠ°Ρ ΠΌΠΎΡΠΈΠ²Π°ΡΠΈΡ ΠΏΡΠΈ ΠΎΡΡΠ΅Π·Π΄Π΅ ΠΈ Π²ΠΎΠ·Π²ΡΠ°ΡΠ΅Π½ΠΈΠΈ, Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ Π½Π° ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈ ΠΏΠΎΡΠΎΠΊΠΈ Π½Π°ΡΡΠ½ΠΎΠΉ ΠΌΠΈΠ³ΡΠ°ΡΠΈΠΈ, ΡΠ²ΡΠ·Ρ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Π½Π°ΡΡΠ½ΡΡ
ΠΊΠΎΠ»Π»Π°Π±ΠΎΡΠ°ΡΠΈΠΉ, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΡΡΡΠ½ΡΡ
. ΠΡΡΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΠ΅ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΏΡΠΈ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΡΡΡΠ½ΡΡ
β ΡΡΠΎ Π°Π½Π°Π»ΠΈΠ· Π°Π½ΠΊΠ΅Ρ Π½Π°ΡΡΠ½ΡΡ
ΡΠΎΡΡΡΠ΄Π½ΠΈΠΊΠΎΠ², ΠΈΠ½ΡΠ΅ΡΠ²ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈ Π½Π°ΡΠΊΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΊΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ Π½Π΅ΡΠ΅ΡΡΠ½Π½ΡΠ΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ Π² ΠΈΠ·ΡΡΠ΅Π½ΠΈΠΈ Π½Π°ΡΡΠ½ΠΎΠΉ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ. Π‘Π΄Π΅Π»Π°Π½ Π²ΡΠ²ΠΎΠ΄ ΠΎ ΡΠΎΠΌ, ΡΡΠΎ Π΄Π΅ΡΠ°Π»ΡΠ½ΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠΎΠ±ΠΈΠ»ΡΠ½ΠΎΡΡΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°ΡΡ ΡΠ΅Π°Π»ΡΠ½ΡΡ ΠΊΠ°ΡΡΠΈΠ½Ρ ΠΊΠ°Π΄ΡΠΎΠ²ΠΎΠ³ΠΎ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° ΡΡΡΠ°Π½Ρ
Erythropoietin mimetic peptide (pHBSP) corrects endothelial dysfunction in a rat model of preeclampsia
Preeclampsia is a severe disease of late pregnancy. Etiological factors and a pathogenetic pattern of events still require significant clarification, but it is now recognized that a large role is played by placentation disorders and emerging endothelial dysfunction. The administration of short-chain peptides mimicking the spatial structure of the B erythropoietin chain may become one of the directions of searching for new drugs for preeclampsia prevention and therap
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