Ultraslow light propagation in an inhomogeneously broadened rare-earth ion-doped crystal

We show that Coherent Population Oscillations effect allows to burn a narrow spectral hole (26Hz) within the homogeneous absorption line of the optical transition of an Erbium ion-doped crystal. The large dispersion of the index of refraction associated with this hole permits to achieve a group velocity as low as 2.7m/s with a ransmission of 40%. We especially benefit from the inhomogeneous absorption broadening of the ions to tune both the transmission coefficient, from 40% to 90%, and the light group velocity from 2.7m/s to 100m/s

MSRE-PCR for analysis of gene-specific DNA methylation

Abnormal DNA methylation is observed in certain promoters of neoplastic cells, although the likelihood of methylation for each individual promoter varies. Simultaneous analysis of many promoters in the same sample can allow use of statistical methods for identification of neoplasia. Here we describe an assay for such analysis, based on digestion of genomic DNA with methylation-sensitive restriction enzyme and multiplexed PCR with gene-specific primers (MSRE-PCR). MSRE-PCR includes extensive digestion of genomic DNA (uncut fragments cannot be identified by PCR), can be applied to dilute samples (<1 pg/μl), requires limited amount of starting material (42 pg or genomic equivalent of seven cells) and can identify methylation in a heterogeneous mix containing <2% of cells with methylated fragments. When applied to 53 promoters of breast cancer cell lines MCF-7, MDA-MB-231 and T47D, MSRE-PCR correctly identified the methylation status of genes analyzed by other techniques. For selected genes results of MSRE-PCR were confirmed by methylation-specific PCR and bisulfite sequencing. The assay can be configured for any number of desired targets in any user-defined set of genes

High-resolution saturation spectroscopy of singly-ionized iron with a pulsed uv laser

We describe the design and realization of a scheme for uv laser spectroscopy of singly-ionized iron (Fe II) with very high resolution. A buffer-gas cooled laser ablation source is used to provide a plasma close to room temperature with a high density of Fe II. We combine this with a scheme for pulsed-laser saturation spectroscopy to yield sub-Doppler resolution. In a demonstration experiment, we have examined an Fe II transition near 260 nm, attaining a linewidth of about 250 MHz. The method is well-suited to measuring transition frequencies and hyperfine structure. It could also be used to measure small isotope shifts in isotope-enriched samples.Comment: 9 pages, 5 figures, updated Fig. 3. For submission to J. Phys.

The Herschel-SPIRE instrument and its in-flight performance

The Spectral and Photometric Imaging REceiver (SPIRE), is the Herschel Space Observatory`s submillimetre camera and spectrometer. It contains a three-band imaging photometer operating at 250, 350 and 500 μm, and an imaging Fourier-transform spectrometer (FTS) which covers simultaneously its whole operating range of 194–671 μm (447–1550 GHz). The SPIRE detectors are arrays of feedhorn-coupled bolometers cooled to 0.3 K. The photometer has a field of view of 4´× 8´, observed simultaneously in the three spectral bands. Its main operating mode is scan-mapping, whereby the field of view is scanned across the sky to achieve full spatial sampling and to cover large areas if desired. The spectrometer has an approximately circular field of view with a diameter of 2.6´. The spectral resolution can be adjusted between 1.2 and 25 GHz by changing the stroke length of the FTS scan mirror. Its main operating mode involves a fixed telescope pointing with multiple scans of the FTS mirror to acquire spectral data. For extended source measurements, multiple position offsets are implemented by means of an internal beam steering mirror to achieve the desired spatial sampling and by rastering of the telescope pointing to map areas larger than the field of view. The SPIRE instrument consists of a cold focal plane unit located inside the Herschel cryostat and warm electronics units, located on the spacecraft Service Module, for instrument control and data handling. Science data are transmitted to Earth with no on-board data compression, and processed by automatic pipelines to produce calibrated science products. The in-flight performance of the instrument matches or exceeds predictions based on pre-launch testing and modelling: the photometer sensitivity is comparable to or slightly better than estimated pre-launch, and the spectrometer sensitivity is also better by a factor of 1.5–2

Deep dives and aortic temperatures of emperor penguins: new directions for bio-logging at the isolated dive hole

In order to document deep (>100 m) dives and aortic temperature responses of emperor penguins (Aptenodytes forsteri) at an isolated dive hole, and also to evaluate a new catheterization technique, three birds were equipped with time depth recorders, temperature data loggers, and percutaneously-inserted aortic thermistors. After recovery from anesthesia, they were provided access for one day to the dive hole. The birds tolerated the experiment without complication. Mean diving duration (+ SE) of 83 dives was 5.9 + 3.1 min; 55% of dives were > 5.6 min, the previously determined aerobic dive limit; 36% were > 100 m in depth. Mean aortic temperatures during 3-h rest periods ranged from 37.3 + 0.2oC to 38.0 + 0.1oC. Mean dive temperature did not correlate with dive duration, and the grand mean of mean dive temperatures in each bird ranged from 38.3 + 0.2oC to 39.0 + 0.2oC; there was no evidence of core hypothermia during dives. Reliable, safe catheterizations, and the large percentage of deep/long dives of these birds should provide the basis both for future studies of pressure adaptation and hypoxemic tolerance in diving emperor penguins, and for investigation of deep-dive foraging behavior

The Cosmic Infrared Background Experiment (CIBER): Instrumentation and First Results

Ultraviolet emission from the first generation of stars in the Universe ionized the intergalactic medium in a process which was completed by z similar to 6; the wavelength of these photons has been redshifted by (1 + z) into the near infrared today and can be measured using instruments situated above the Earth's atmosphere. First flying in February 2009, the Cosmic Infrared Background ExpeRiment (CIBER) comprises four instruments housed in a single reusable sounding rocket borne payload. CIBER will measure spatial anisotropies in the extragalactic IR background caused by cosmological structure from the epoch of reionization using two broadband imaging instruments, make a detailed characterization of the spectral shape of the IR background using a low resolution spectrometer, and measure the absolute brightness of the Zodiacal light foreground with a high resolution spectrometer in each of our six science fields. The scientific motivation for CIBER and details of its first and second flight instrumentation will be discussed. First flight results on the color of the zodiacal light around 1 mu m and plans for the future will also be presented

Observations of the Near-infrared Spectrum of the Zodiacal Light with CIBER

Interplanetary dust (IPD) scatters solar radiation which results in the zodiacal light that dominates the celestial diffuse brightness at optical and near-infrared wavelengths. Both asteroid collisions and cometary ejections produce the IPD, but the relative contribution from these two sources is still unknown. The low resolution spectrometer (LRS) onboard the Cosmic Infrared Background ExpeRiment (CIBER) observed the astrophysical sky spectrum between 0.75 and 2.1 μm over a wide range of ecliptic latitude. The resulting zodiacal light spectrum is redder than the solar spectrum, and shows a broad absorption feature, previously unreported, at approximately 0.9 μm, suggesting the existence of silicates in the IPD material. The spectral shape of the zodiacal light is isotropic at all ecliptic latitudes within the measurement error. The zodiacal light spectrum, including the extended wavelength range to 2.5 μm using Infrared Telescope in Space (IRTS) data, is qualitatively similar to the reflectance of S-type asteroids. This result can be explained by the proximity of S-type asteroidal dust to Earth's orbit, and the relatively high albedo of asteroidal dust compared with cometary dust

X-ray spectral properties of Seyfert galaxies and the unification scheme

Aims: The unification scheme of Seyfert galaxies predicts that the observed differences between type 1 and type 2 Seyfert galaxies are solely due to the differing orientations of the toroidal-shaped obscuring material around AGN. The observed X-ray spectra of Seyfert type 2s compared to type 1s are expected to be affected by higher absorbing column density due to the edge-on view of the obscuring torus. We study the 0.5 - 10 keV X-ray spectral properties of Seyfert type 1s and type 2s with the aim to test the predictions of Seyfert unification scheme in the X-ray regime. Methods: We use an optically selected Seyfert sample in which type 1s and type 2s have matched distributions in the orientation independent parameters of AGN and host galaxy. Results: The 0.5 - 10 keV XMM-Newton pn X-ray spectra of Seyfert galaxies are in general best fitted with a model consists of an absorbed power-law, a narrow Gaussian fitted to the Fe K{\alpha} emission line and an often seen soft excess component characterized by either a thermal plasma model with temperature kT \sim 0.1 - 1.0 keV and/or a steep power-law. The 2.0 - 10 keV hard X-ray continuum emission in several Seyfert type 2s is reflection dominated and suggests the Compton-thick obscuration. Results on the statistical comparison of the distributions of the observed X-ray luminosities in the soft (0.5 - 2.0 keV) and hard (2.0 - 10.0 keV) bands, the X-ray absorbing column densities, the equivalent widths of Fe K{\alpha} line and the flux ratios of hard X-ray to [OIII] {\lambda}5007{\AA} for the two Seyfert subtypes are consistent with the obscuration and orientation based unification scheme.Comment: 15 pages, 3 figures, 6 tables, accepted for publication in A&

A 5-year-old with new-onset diabetes presenting with ketoacidosis, acute pancreatitis, and renal failure

A 5-year-old girl presented to the emergency room with altered mental status secondary to severe diabetic ketoacidosis due to new-onset GAD65 antibody positive, type 1 diabetes mellitus. On hospital day 0, she developed anuria, shock, and hypertriglyceridemia-associated acute pancreatitis. Following intravenous insulin therapy, the patient?s ketoacidosis improved. Her other complications persisted for several days and improved only with significant fluid resuscitation and supportive interventions, including intubation, thoracostomy, and vasopressors. This case underscores the importance of recognizing the early warning signs of diabetic ketoacidosis and reviews how to appropriately manage its associated life-threatening complications