The role of apical support and rectal mucosal prolapse excision in successful treatment of rectocele combined with perineum descending: short-term and follow-up results

The aim of the research was to improve the results of surgery treatment of posterior compartment of pelvic floor using abdominal sacrocolpopexy and stapled trance-anal resection (STARR

The advantages of the abdominal sacral colpopexy combined with stapled trance-anal resection of the rectal mucosal prolapse (STARR) for the surgical treament of perineum descending syndrome

The problem of pelvic organ prolapse in women is still actual, because of high frequency of this pathology. Several surgical techniques have been suggested for pelvic descending syndrome treatment. But a large number of complications, unsatisfactory anatomical and functional results of suggested methods force to look for other solutions of the proble

The role of polymorphism of hereditary thrombophilia candidate genes in the development of arterial hypertension in women with preeclampsia

Preeclampsia is a severe pregnancy complication that has long been one of the leading causes of maternal and perinatal mortality and morbidity worldwide. Despite the achievements of modern medicine, the etiology of this pathology is not known. Multiple risk factors for the development of PE have been identified: arterial hypertension, diabetes mellitus, obesity, a hereditary history of preeclampsia, thrombophilia, etc., but recently, special attention has been paid to genetic determinants, namely, the contribution of individual polymorphic loci of various gene

Spontaneous Branching of Anode-Directed Streamers between Planar Electrodes

Non-ionized media subject to strong fields can become locally ionized by penetration of finger-shaped streamers. We study negative streamers between planar electrodes in a simple deterministic continuum approximation. We observe that for sufficiently large fields, the streamer tip can split. This happens close to Firsov's limit of `ideal conductivity'. Qualitatively the tip splitting is due to a Laplacian instability quite like in viscous fingering. For future quantitative analytical progress, our stability analysis of planar fronts identifies the screening length as a regularization mechanism.Comment: 4 pages, 6 figures, submitted to PRL on Nov. 16, 2001, revised version of March 10, 200

Insilico test of functional role of rs8068318 polymorphism of arterial hypertension-associated TBX2 candidate gene

In the course of this study, the functional role of rs8068318 polymorphism of the TBX2 candidate gene associated with the development of arterial hypertension was studied. The selection of the polymorphic locus was based on the data of the catalog of genome-wide association study (GWAS) of the National Human Genome Research Institute. The functional role was evaluated using online software: HaploReg (v4.1), GTExportal, and PolyPhen-

Endoscopic surgical interventions in the treatment of periampullary cancer

In this paper retrospective treatment result analysis of 386 patients with periampullary cancer, complications are carried out by obstructive jaundice. Patients were organized into two groups: the first group patients to whom traditional surgical interventions were applied, and entered the second – treated with endoscopic transpapillary surgeries. We have shown that at the nonresectable cancer of bodies of a pancreatoduodenal zone complicated by obstructive jaundice, endoscopic transpapillary interventions are the main method of decompression of a biliary tree, thus allowing complete avoidance of traditional surgical intervention

Positive and negative streamers in ambient air: modeling evolution and velocities

We simulate short positive and negative streamers in air at standard temperature and pressure. They evolve in homogeneous electric fields or emerge from needle electrodes with voltages of 10 to 20 kV. The streamer velocity at given streamer length depends only weakly on the initial ionization seed, except in the case of negative streamers in homogeneous fields. We characterize the streamers by length, head radius, head charge and field enhancement. We show that the velocity of positive streamers is mainly determined by their radius and in quantitative agreement with recent experimental results both for radius and velocity. The velocity of negative streamers is dominated by electron drift in the enhanced field; in the low local fields of the present simulations, it is little influenced by photo-ionization. Though negative streamer fronts always move at least with the electron drift velocity in the local field, this drift motion broadens the streamer head, decreases the field enhancement and ultimately leads to slower propagation or even extinction of the negative streamer.Comment: 18 pages, 10 figure

The study of the associations of polymorphism of matrix metalloproteinases with multifactorial human diseases and in silico assessment of their functional effects

The objective of this study is to identify the associations of polymorphism of matrix metalloproteinase genes with multifactorial diseases and evaluate in silico their functional effects. The material for the study was genomic DNA isolated from venous blood samples by the standard phenol-chloroform extraction method. The rs2250889 MMP9, rs11568818 MMP7 and rs17576 MMP9 polymorphic loci were studied using the polymerase chain reaction on a CFX-96 Real-Time System thermal cycler (Bio-Rad Laboratories, Inc., US) using oligonucleotide primers and probes synthesized by Syntol LLC, Russia

The OSACA Database and a Kinematic Analysis of Stars in the Solar Neighborhood

We transformed radial velocities compiled from more than 1400 published sources, including the Geneva--Copenhagen survey of the solar neighborhood (CORAVEL-CfA), into a uniform system based on the radial velocities of 854 standard stars in our list. This enabled us to calculate the average weighted radial velocities for more than 25~000 HIPPARCOS stars located in the local Galactic spiral arm (Orion arm) with a median error of +-1 km/s. We use these radial velocities together with the stars' coordinates, parallaxes, and proper motions to determine their Galactic coordinates and space velocities. These quantities, along with other parameters of the stars, are available from the continuously updated Orion Spiral Arm CAtalogue (OSACA) and the associated database. We perform a kinematic analysis of the stars by applying an Ogorodnikov-Milne model to the OSACA data. The kinematics of the nearest single and multiple main-sequence stars differ substantially. We used distant (r\approx 0.2 kpc) stars of mixed spectral composition to estimate the angular velocity of the Galactic rotation -25.7+-1.2 km/s/kpc, and the vertex deviation,l=13+-2 degrees, and detect a negative K effect. This negative K effect is most conspicuous in the motion of A0-A5 giants, and is equal to K=-13.1+-2.0 km/s/kpc.Comment: 16 pages, 8 figure

On the effect of transport coefficient anisotropy on the plasma flow in heliospheric interface

The plasma flow in the heliospheric interface is considered. The applicability of hydrodynamic description for this flow is studied. The effect of the magnetic field on the transport properties in the interface plasma is discussed and the dimensionless parameters related to the plasma flow are estimated. It is found that both resistivity and Hall effect can be neglected in Ohm's law, so that the classical induction equation of the ideal magnetohydrodynamic can be used. The Reynolds number is moderately large, so the approximation of inviscid plasma is fairly good. The most important dissipative process is thermal conduction along the magnetic field lines. This effect has to be definitely taken into account. The results obtained in the paper are used to outline the ways for advancing the existing models of the heliospheric interface