Improved crowd psychological model and control

The behavior of human crowd is an interesting phenomenon in which individuals are set as a collection that comprises of a highly dynamic social group. The crowd behaviors have been investigated by researchers over the years. Recent works include the study in modeling and controlling of the dynamic psychological behavior of crowds such as students’ behavior in a classroom or people’s behavior in a one-dimensional queue. In this paper, an improved version of the psychological crowd model has been proposed, where the social interaction between two individuals in a crowd is represented by a weightage, called the weight of social interaction. It has been shown that the inclusion of the social interaction weight has allowed social interactions between individuals to be included and results in a more accurate representation of the crowd’s psychological factors propagations. Since the psychological dynamics of crowd is naturally unstable, this paper also discusses the application of two nonlinear control approaches to stabilise the crowd to make it calm. Results show that for a crowd of n number of agents, the single-agent controller gives similar performance with the n-agent controller but with much less resources. The simulation results also show that it takes less amount of time to stabilise a crowd when the crowd model includes social interaction weights

The theory of optical dispersive shock waves in photorefractive media

The theory of optical dispersive shocks generated in propagation of light beams through photorefractive media is developed. Full one-dimensional analytical theory based on the Whitham modulation approach is given for the simplest case of sharp step-like initial discontinuity in a beam with one-dimensional strip-like geometry. This approach is confirmed by numerical simulations which are extended also to beams with cylindrical symmetry. The theory explains recent experiments where such dispersive shock waves have been observed.Comment: 26 page

Depletion of homeostatic antibodies against malondialdehyde-modified low-density lipoprotein correlates with adverse events in major vascular surgery

We aimed to investigate if major vascular surgery induces LDL oxidation, and whether circulating antibodies against malondialdehyde-modified LDL (MDA-LDL) alter dynamically in this setting. We also questioned relationships between these biomarkers and post-operative cardiovascular events. Major surgery can induce an oxidative stress response. However, the role of the humoral immune system in clearance of oxidized LDL following such an insult is unknown. Plasma samples were obtained from a prospective cohort of 131 patients undergoing major non-cardiac vascular surgery, with samples obtained preoperatively and at 24- and 72 h postoperatively. Enzyme-linked immunoassays were developed to assess MDA-LDL-related antibodies and complexes. Adverse events were myocardial infarction (primary outcome), and a composite of unstable angina, stroke and all-cause mortality (secondary outcome). MDA-LDL significantly increased at 24 h post-operatively (p < 0.0001). Conversely, levels of IgG and IgM anti-MDA-LDL, as well as IgG/IgM-MDA-LDL complexes and total IgG/IgM, were significantly lower at 24 h (each p < 0.0001). A smaller decrease in IgG anti-MDA-LDL related to combined clinical adverse events in a post hoc analysis, withstanding adjustment for age, sex, and total IgG (OR 0.13, 95% CI [0.03–0.5], p < 0.001; p value for trend <0.001). Major vascular surgery resulted in an increase in plasma MDA-LDL, in parallel with a decrease in antibody/complex levels, likely due to antibody binding and subsequent removal from the circulation. Our study provides novel insight into the role of the immune system during the oxidative stress of major surgery, and suggests a homeostatic clearance role for IgG antibodies, with greater reduction relating to downstream adverse events

Epidemiology of methicillin-resistant Staphylococcus aureus: results of a nation-wide survey in Switzerland.

To assess the epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in Switzerland. One-year national survey of all MRSA cases detected in a large sample of Swiss healthcare institutions (HCI). Analysis of epidemiological and molecular typing data (PFGE) of MRSA strains. During 1997, 385 cases of MRSA were recorded in the 5 university hospitals, in 33 acute care community hospitals, and 14 rehabilitation or long-term care institutions. Half of the cases were found at the University of Geneva Hospitals where MRSA was already known to be endemic (41.1 cases/10,000 admissions). The remaining cases (200) were distributed throughout Switzerland. The highest rates (&gt;100 cases/10,000 admissions) were reported from non-acute care institutions. Rates ranged from 3.3 to 41.1 cases/10,000 admissions for university hospitals (mean 15.5); 0.67 to 90.4 for community hospitals (mean 4.8), and 28.2 to 315 for non-acute care institutions reporting MRSA (mean 85.7). Forty percent of MRSA patients were infected, while 60% were only colonised. The leading infection sites were skin and soft tissue (21%), surgical site (15%), and the urinary tract (26%). Whereas in Eastern Swiss HCI most MRSA cases occurred in acute care hospitals (n = 47, 98%), rehabilitation and long-term care institutions accounted for an important number of the identified cases (n = 107, 38%) in Western Switzerland. Low rates of MRSA were still observed in Swiss HCI, despite one outlying acute care centre with endemic MRSA and some nonacute care institutions with epidemic MRSA. Rehabilitation and long-term care institutions contributed to a substantial proportion of cases in Western Switzerland and may constitute a significant reservoir. Overall, a national approach to surveillance and control of MRSA is mandatory in order to preserve a still favourable situation, and to decrease the risk of epidemic MRSA dissemination

Water quality digital twin survey

Stakeholders’ views on the creation of a Water Quality Digital Twin, for assessing the impacts of multiple stressors on standing and flowing freshwaters, were sought through an anonymous survey composed of closed and open questions. The work was funded as part of the UKSCAPE integration fund (https://ukscape. ceh.ac.uk/about ) and sought to co-develop a blueprint for a UKCEH water quality digital twin. Fifty-nine participants responded and provided a wealth of viewpoints, from academia, industry, regulators, and policy makers’ perspectives. In general, the catchment scale was considered the most feasible, useful, realistic, and deliverable scale for a Water Quality Digital Twin. Respondents considered the desired temporal scale to be dependent on the use envisaged for the digital twin. However, sub-daily or daily scales emerged as providing the most actionable knowledge if data were available and it was computationally feasible. Overall, there was consensus that nutrient concentrations were the most important determinands to include in a water quality digital twin (100% of respondents scoring these as one of their three most important determinand categories). However, several additional abiotic and biotic determinands were also scored highly, partly depending on the required use of the resultant digital twin

Nonlinear diffraction of light beams propagating in photorefractive media with embedded reflecting wire

The theory of nonlinear diffraction of intensive light beams propagating through photorefractive media is developed. Diffraction occurs on a reflecting wire embedded in the nonlinear medium at relatively small angle with respect to the direction of the beam propagation. It is shown that this process is analogous to the generation of waves by a flow of a superfluid past an obstacle. The ``equation of state'' of such a superfluid is determined by the nonlinear properties of the medium. On the basis of this hydrodynamic analogy, the notion of the ``Mach number'' is introduced where the transverse component of the wave vector plays the role of the fluid velocity. It is found that the Mach cone separates two regions of the diffraction pattern: inside the Mach cone oblique dark solitons are generated and outside the Mach cone the region of ``ship waves'' is situated. Analytical theory of ``ship waves'' is developed and two-dimensional dark soliton solutions of the equation describing the beam propagation are found. Stability of dark solitons with respect to their decay into vortices is studied and it is shown that they are stable for large enough values of the Mach number.Comment: 18 page

Endothelial repair in stented arteries is accelerated by inhibition of Rho-associated protein kinase.

AIMS: Stent deployment causes endothelial cell (EC) denudation, which promotes in-stent restenosis and thrombosis. Thus endothelial regrowth in stented arteries is an important therapeutic goal. Stent struts modify local hemodynamics, however the effects of flow pertubation on EC injury and repair are incompletely understood. By studying the effects of stent struts on flow and EC migration we identified an intervention that promotes endothelial repair in stented arteries. METHODS AND RESULTS: In vitro and in vivo models were developed to monitor endothelialization under flow and the influence of stent struts. A 2D parallel-plate flow chamber with 100 μm ridges arranged perpendicular to the flow was used. Live cell imaging coupled to computational fluid dynamic simulations revealed that EC migrate in the direction of flow upstream from the ridges but subsequently accumulate downstream from ridges at sites of bidirectional flow. The mechanism of EC trapping by bidirectional flow involved reduced migratory polarity associated with altered actin dynamics. Inhibition of Rho-associated protein kinase (ROCK) enhanced endothelialization of ridged surfaces by promoting migratory polarity under bidirectional flow (p<0.01). To more closely mimic the in vivo situation we cultured EC on the inner surface of polydimethylsiloxane tubing containing Coroflex Blue stents (65 μm struts) and monitored migration. ROCK inhibition significantly enhanced EC accumulation downstream from struts under flow (p<0.05). We investigated the effects of ROCK inhibition on re-endothelialization in vivo using a porcine model of EC denudation and stent placement. En face staining and confocal microscopy revealed that inhibition of ROCK using fasudil (30 mg/day via osmotic minipump) significantly increased re-endothelialization of stented carotid arteries (p<0.05). CONCLUSIONS: Stent struts delay endothelial repair by generating localised bidirectional flow which traps migrating EC. ROCK inhibitors accelerate endothelial repair of stented arteries by enhancing EC polarity and migration through regions of bidirectional flow