Acute pituitary insufficiency and hypokalaemia following envenoming by Russell's viper (Daboia russelii) in Sri Lanka: Exploring the pathophysiological mechanisms.

Russell's viper envenoming is associated with a high incidence of morbidity and mortality. Hypopituitarism following envenoming by Russell's vipers is a well recognized sequel in Burma and parts of India but has been reported only once in Sri Lanka. Hypokalaemia following envenoming by Russell's viper has not been described. Here we describe the association of acute pituitary insufficiency and hypokalaemia following Russell's viper envenoming in Sri Lanka and review the literature in order to understand its pathophysiological basis. A previously healthy 21-year-old man was envenomed by a Russell's viper and treated with antivenom. Ten hours after the bite, he developed persistent hypotension, which responded promptly to intravenous dexamethasone. His hormone profiles were consistent with hypocortisolism secondary to acute pituitary insufficiency. He also developed hypokalaemia. Analysis of urine and serum electrolytes suggested redistribution of potassium in to the cells rather than renal loss. Hypotension and hypoglycaemic coma are life-threatening manifestations of acute pituitary insufficiency. Therefore prompt steroid administration in these setting is life saving. Awareness of these complications among physicians would help to make prompt diagnosis and initiate immediate life saving treatment

Addressing the relationship between cardiac hypertrophy and ischaemic stroke: An observational study

Introduction. Research over the last decade has recognized left ventricular hypertrophy as a risk factor for major cardiovascular events including stroke. While cardiac magnetic resonance imaging is the best modality to quantify left ventricular hypertrophy, echocardiographic calculation of left ventricular mass index is a reasonable alternative. Methods. We carried out a hospital based prospective study to identify the prevalence of left ventricular hypertrophy, assessed using echocardiography, in patients presenting with ischaemic strokes. This is the first study that attempted to quantify this issue in a cohort of Sri Lankan patients. The study was carried out in the National Hospital of Sri Lanka over a period of 6 months. Results: A total of 55 patients (44 males, 80%) (mean age: 62.3, range: 48-82 years) with ischaemic strokes were studied. Of them, only 38 could be mobilized to measure the height and weight to calculate the left ventricular mass index. Of the rest, only one person had the electrocardiographic criteria for left ventricular hypertrophy. Of the 38 patients evaluated, 29 (76.3%) had left ventricular hypertrophy while 19 (50%) had severe hypertrophy. Discussion and conclusions. The rates of left ventricular hypertrophy reported in similar studies in other countries vary between 25-62%. Given the high prevalence of left ventricular hypertrophy reported in this study and its recognition as a risk factor for stroke recently, together with the availability of effective treatment for risk reduction, the cost effectiveness of population screening should be evaluated. Further studies are planned in this regard. © 2012 Rodrigo et al.; licensee BioMed Central Ltd

Pancreatitis and myocarditis followed by pulmonary hemorrhage, a rare presentation of leptospirosis- A case report and literature survey

<p>Abstract</p> <p>Background</p> <p>Leptospirosis is a potentially fatal disease which can cause multi-organ dysfunction. It can rarely present as acute pancreatitis. This is the first ever report of leptospirosis presenting with acute pancreatitis and myocarditis followed by diffuse pulmonary hemorrhages to the best of our knowledge.</p> <p>Case presentation</p> <p>A 15-year-old South Asian boy presented with high grade fever, epigastric discomfort and was anicteric on admission. He developed tachycardia, transient hypotension, changes of electro-cardiogram and positive troponin I suggestive of myocarditis. Acute pancreatitis was diagnosed with 12 fold high serum amylase and with the evidence of computerized tomography. Then he developed diffuse pulmonary hemorrhages and later acute renal failure. Leptospirosis was confirmed by positive leptospira IgM, negative IgG and strongly positive Microscopic Agglutination Test. Other possible infective and autoimmune causes were excluded. Patient recovered completely with antibiotics and the supportive care.</p> <p>Conclusion</p> <p>This case illustrates diagnostic difficulties especially in resource poor settings where leptospirosis is common. Additionally it highlights the fact that leptospirosis should be considered in patients presenting with pancreatitis which can be complicated with myocarditis and diffuse pulmonary hemorrhages. We hypothesize that Toll like receptors may play a role in such systemic involvement.</p