101 research outputs found
A novel 9 kDa phosphoprotein is a component of the primary cilium and interacts with polycystin-1
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are
Multivariate analysis of the influence of peri-implant clinical parameters and local factors on radiographic bone loss in the posterior maxilla: a retrospective study on 277 dental implants
Objectives: The aim of the present study was to investigate whether peri-implant clinical parameters (modified plaque index (mPI), bleeding and/or suppuration on probing (B/SOP)) and local factors (type of prostheses, screw emergence, platform diameter, and abutment angulation) might contribute to the development of additional bone loss and peri-implantitis around dental implants. Materials and methods: Two hundred seventy-seven external hex connection implants placed in the posterior maxilla of 124 patients were retrospectively evaluated. They were divided into two groups: physiologic bone loss < 2 mm (PBL) or additional bone loss ≥ 2 mm (ABL). GEE logistic regression was applied to evaluate the influence of type of prostheses (implant-supported single crown (ISSC), fixed partial denture (ISFPD), and full denture (ISFD)) and clinical parameters (mPI and S/BOP) on bone loss. Results: Among the 277 implants, 159 (57.4%) presented PBL and 118 (42.6%) presented ABL. Within the ABL group, 20.6% implants were diagnosed with peri-implantitis. mPI significantly correlated with the type of prosthesis and the highest value of mPI (index = 3) was observed in ISFD (23.8%). Moreover, peri-implantitis was more frequently associated with ISFD (32.79%) than ISSC and ISFDP (13.79% and 13.48, respectively) Conclusions: ISFD in the posterior maxilla presented high rates of ABL and showed a higher prevalence of peri-implantitis. None of the local factors seemed to contribute to the development of these conditions. Further investigations are needed to prospectively support the results of the present study. Clinical relevance: Patients rehabilitated with ISFD should be carefully monitored and have more frequent maintenance visits to prevent or control peri-implant bone loss
Role of heavy-meson exchange in pion production near threshold
Recent calculations of -wave pion production have severely underestimated
the accurately known \ total cross section near
threshold. In these calculations, only the single-nucleon axial-charge operator
is considered. We have calculated, in addition to the one-body term, the
two-body contributions to this reaction that arise from the exchange of mesons.
We find that the inclusion of the scalar -meson exchange current (and
lesser contributions from other mesons) increases the cross section by about a
factor of five, and leads to excellent agreement with the data. The results are
neither very sensitive to changes in the distorting potential that generates
the wave function, nor to different choices for the meson-nucleon form
factors. We argue that \ data provide direct
experimental evidence for meson-exchange contributions to the axial current.Comment: 28 Pages, IU-NTC #93-0
QCD Sum Rules for Hyperons in Nuclear Matter
Within finite-density QCD sum-rule approach we investigate the self-energies
of hyperons propagating in nuclear matter from a correlator of
interpolating fields evaluated in the nuclear matter ground state. We
find that the Lorentz vector self-energy of the is similar to the
nucleon vector self-energy. The magnitude of Lorentz scalar self-energy of the
is also close to the corresponding value for nucleon; however, this
prediction is sensitive to the strangeness content of the nucleon and to the
assumed density dependence of certain four-quark condensate. The scalar and
vector self-energies tend to cancel, but not completely. The implications for
the couplings of to the scalar and vector mesons in nuclear matter and
for the spin-orbit force in a finite nucleus are discussed.Comment: 20 pages in revtex, 6 figures available under request as ps files,
UMD preprint #94--11
Derivative-Coupling Models and the Nuclear-Matter Equation of State
The equation of state of saturated nuclear matter is derived using two
different derivative-coupling Lagrangians. We show that both descriptions are
equivalent and can be obtained from the sigma-omega model through an
appropriate rescaling of the coupling constants. We introduce generalized forms
of this rescaling to study the correlations amongst observables in infinite
nuclear matter, in particular, the compressibility and the effective nucleon
mass.Comment: 16 pages, 6 figures, 36 kbytes. To appear in Zeit. f. Phys. A
(Hadrons and Nuclei
Effect of calcium-sensing receptor activation in models of autosomal recessive or dominant polycystic kidney disease
Background. Antagonists of relevant Gs protein-coupled and agonists of relevant Gi protein-coupled receptors lower renal cAMP and inhibit growth of renal cysts in animal models of human ARPKD (PCK rat) and/or ADPKD (Pkd2−/WS25 mouse). A calcium-sensing receptor (CaR) is expressed in various tubular segments and couples to Gq, thereby activating phospholipase Cγ, InsP3 generation and calcium mobilization from intracellular stores, and Gi proteins. By both mechanisms, CaR activation could lower intracellular cAMP and inhibit renal cyst growth
Strangeness nuclear physics: a critical review on selected topics
Selected topics in strangeness nuclear physics are critically reviewed. This
includes production, structure and weak decay of --Hypernuclei, the
nuclear interaction and the possible existence of bound
states in nuclei. Perspectives for future studies on these issues are also
outlined.Comment: 63 pages, 51 figures, accepted for publication on European Physical
Journal
A Decommissioned LHC Model Magnet as an Axion Telescope
The 8.4 Tesla, 10 m long transverse magnetic field of a twin aperture LHC
bending magnet can be utilized as a macroscopic coherent solar axion-to-photon
converter. Numerical calculations show that the integrated time of alignment
with the Sun would be 33 days per year with the magnet on a tracking table
capable of in the vertical direction and in the horizontal
direction. The existing lower bound on the axion-to-photon coupling constant
can be improved by a factor between 50 and 100 in 3 years, i.e.,
for axion masses
1 eV. This value falls within the existing open axion mass window.
The same set-up can simultaneously search for low- and high-energy celestial
axions, or axion-like particles, scanning the sky as the Earth rotates and
orbits the Sun.Comment: Final version, accepted for publication in Nucl. Instr. Meth. A. More
information can be found at http://wwwinfo.cern.ch/~collar/SATAN/alvaro.htm
Experimental Search for Solar Axions via Coherent Primakoff Conversion in a Germanium Spectrometer
Results are reported of an experimental search for the unique, rapidly
varying temporal pattern of solar axions coherently converting into photons via
the Primakoff effect in a single crystal germanium detector. This conversion is
predicted when axions are incident at a Bragg angle with a crystalline plane.
The analysis of approximately 1.94 kg.yr of data from the 1 kg DEMOS detector
in Sierra Grande, Argentina, yields a new laboratory bound on axion-photon
coupling of GeV, independent of
axion mass up to ~ 1 keV.Comment: RevTeX, 11 pages, figures can be obtained by fax from
[email protected]. Submitted to Phys. Lett.
Nephronophthisis
Nephronophthisis (NPH) is an autosomal recessive disease characterized by a chronic tubulointerstitial nephritis that progress to terminal renal failure during the second decade (juvenile form) or before the age of 5 years (infantile form). In the juvenile form, a urine concentration defect starts during the first decade, and a progressive deterioration of renal function is observed in the following years. Kidney size may be normal, but loss of corticomedullary differentiation is often observed, and cysts occur usually after patients have progressed to end-stage renal failure. Histologic lesions are characterized by tubular basement membrane anomalies, tubular atrophy, and interstitial fibrosis. The infantile form is characterized by cortical microcysts and progression to end-stage renal failure before 5 years of age. Some children present with extrarenal symptoms: retinitis pigmentosa (Senior-Løken syndrome), mental retardation, cerebellar ataxia, bone anomalies, or liver fibrosis. Positional cloning and candidate gene approaches led to the identification of eight causative genes (NPHP1, 3, 4, 5, 6, 7, 8, and 9) responsible for the juvenile NPH and one gene NPHP2 for the infantile form. NPH and associated disorders are considered as ciliopathies, as all NPHP gene products are expressed in the primary cilia, similarly to the polycystic kidney disease (PKD) proteins
- …