The Bernoulli sieve revisited

We consider an occupancy scheme in which "balls" are identified with $n$ points sampled from the standard exponential distribution, while the role of "boxes" is played by the spacings induced by an independent random walk with positive and nonlattice steps. We discuss the asymptotic behavior of five quantities: the index $K_n^*$ of the last occupied box, the number $K_n$ of occupied boxes, the number $K_{n,0}$ of empty boxes whose index is at most $K_n^*$, the index $W_n$ of the first empty box and the number of balls $Z_n$ in the last occupied box. It is shown that the limiting distribution of properly scaled and centered $K_n^*$ coincides with that of the number of renewals not exceeding $\log n$. A similar result is shown for $K_n$ and $W_n$ under a side condition that prevents occurrence of very small boxes. The condition also ensures that $K_{n,0}$ converges in distribution. Limiting results for $Z_n$ are established under an assumption of regular variation.Comment: Published in at http://dx.doi.org/10.1214/08-AAP592 the Annals of Applied Probability (http://www.imstat.org/aap/) by the Institute of Mathematical Statistics (http://www.imstat.org

Muslim and Gay: Seeking identity coherence in New Zealand

This is an Accepted Manuscript of an article published by Taylor & Francis in Culture, Health & Sexuality on 2015, available online: https://www.tandfonline.com/doi/full/10.1080/13691058.2015.1079927The process of accepting oneself as gay and of ‘coming out’ to family and friends is well documented. For Muslim men, this is complicated by the tension between their emerging sexual identity and their religious and cultural birth identity, which labels homosexuality as sinful. This paper explores this process in a sample of five gay Muslim men living in New Zealand, a liberal secular society where homosexuality is widely accepted and gay rights are endorsed in legislation. Identity Process Theory drives the analysis, which identifies five themes encapsulating the process of striving for psychological coherence: resistance, acceptance, tension, renegotiation and pretence. Initial phases of denial and anger at their emerging sexuality are strongly linked to the conflict with their religious identity. Later, acceptance of their sexuality as natural and even God-given protects them from blame for their ‘sins’. In contrast to earlier work in the UK, for most men, renegotiation of their Muslim identity is adopted as the key strategy for achieving intrapsychic coherence. However, at an interpersonal level, families remain a source of conflict, temporarily resolved through pretence. Renegotiating religious identity leaves men having to pretend not just to be straight, but also to be strongly religious.tru

Bringing research results to users: the case for a knowledge resource centre

Poster presented at Scientific and Technical Information and Rural Development: Highlights of Innovative Practices. 13. IAALD World Congress. Montpellier (France), 26-29 Apr 201

Therapy of Canine Hyperlipidemia with Bezafibrate.

BackgroundBezafibrate (BZF) is effective in the treatment of hypertriglyceridemia in human patients, but there are no data on its use in dogs.ObjectiveTo assess the safety of BZF in hyperlipidemic dogs and its efficacy in decreasing serum triglyceride (TG) and cholesterol (CHO) concentrations.AnimalsForty-six dogs, 26 females and 20 males, mean (±SD) age of 9 (±3) years, with TG ≥150 mg/dL (33 dogs also were hypercholesterolemic [>300 mg/dL]).MethodsProspective, uncontrolled clinical trial. Dogs were treated with bezafibrate once daily, using 200 mg tablets at a dosage of 4-10 mg/kg (depending on body weight). Serum TG and CHO concentrations and alanine aminotransferase (ALT) and creatine kinase (CK) activity before and after 30 days of treatment were compared.ResultsSixteen dogs (34.8%) had primary hyperlipidemia, and 30 dogs (65.2%) had secondary hyperlipidemia (including spontaneous hyperadrenocorticism [41.3%, n = 19/46], chronic treatment with glucocorticoids [10.8%, n = 5/46], and hypothyroidism [15.2%, n = 7/46]). After 30 days, serum TG concentration normalized (<150 mg/dL) in 42 dogs (91.3%) and CHO concentration normalized (<270 mg/dL) in 22 of 33 dogs (66.7%). There was no difference in baseline TG concentration between the primary and secondary hyperlipidemia subgroups, but the decrease in TG concentration after treatment was greater in the primary hyperlipidemia subgroup. No adverse effects were observed, but ALT activity decreased significantly after 30 days of treatment.Conclusions and clinical importanceOver 30 days, BZF was safe and effective in treatment of primary and secondary hyperlipidemia in dogs

Subsquares Approach - Simple Scheme for Solving Overdetermined Interval Linear Systems

In this work we present a new simple but efficient scheme - Subsquares approach - for development of algorithms for enclosing the solution set of overdetermined interval linear systems. We are going to show two algorithms based on this scheme and discuss their features. We start with a simple algorithm as a motivation, then we continue with a sequential algorithm. Both algorithms can be easily parallelized. The features of both algorithms will be discussed and numerically tested.Comment: submitted to PPAM 201

Calibration of colour gradient bias in shear measurement using HST/CANDELS data

Accurate shape measurements are essential to infer cosmological parameters from large area weak gravitational lensing studies. The compact diffraction-limited point-spread function (PSF) in space-based observations is greatly beneficial, but its chromaticity for a broad band observation can lead to new subtle effects that could hitherto be ignored: the PSF of a galaxy is no longer uniquely defined and spatial variations in the colours of galaxies result in biases in the inferred lensing signal. Taking Euclid as a reference, we show that this colourgradient bias (CG bias) can be quantified with high accuracy using available multi-colour Hubble Space Telescope (HST) data. In particular we study how noise in the HST observations might impact such measurements and find this to be negligible. We determine the CG bias using HST observations in the F606W and F814W filters and observe a correlation with the colour, in line with expectations, whereas the dependence with redshift is weak. The biases for individual galaxies are generally well below 1%, which may be reduced further using morphological information from the Euclid data. Our results demonstrate that CG bias should not be ignored, but it is possible to determine its amplitude with sufficient precision, so that it will not significantly bias the weak lensing measurements using Euclid data

Cellular cholesterol and how to find it

Cholesterol is an essential component of eukaryotic cellular membranes. Information about its subcellular localization and transport pathways inside cells are key for the understanding and treatment of cholesterol-related diseases. In this review we give an overview over the most commonly used methods that contributed to our current understanding of subcellular cholesterol localization and transport routes. First, we discuss methods that provide insights into cholesterol metabolism based on readouts of downstream effects such as esterification. Subsequently, we focus on the use of cholesterol-binding molecules as probes that facilitate visualization and quantification of sterols inside of cells. Finally, we explore different analogues of cholesterol which, when taken up by living cells, are integrated and transported in a similar fashion as endogenous sterols. Taken together, we highlight the challenges and advantages of each method such that researchers studying aspects of cholesterol transport may choose the most pertinent approach for their problem