Paleomagnetism and cycle stratigraphy of the Triassic Fleming Fjord and Gipsdalen Formations of East Greenland

A 210 m section of Late Triassic Fleming Fjord Formation (the Malmros Klint Member and the lowermost 80m of the overlying Carlsberg Fjord beds of the à˜rsted Dal Member) in the Tait Bjerg area of the Jameson Land Basin, East Greenland, was sampled for paleomagnetic study and measured for cycle stratigraphie analysis. Paleomagnetic samples were also taken from the underlying Gipsdalen Formation in the Gipsdalen area. A high stability characteristic magnetization carried by hematite was successfully isolated in 63 sampling levels in the Fleming Fjord Formation and 9 sampling sites in the Gipsdalen Formation using progressive thermal demagnetization. The mean characteristic directions for the Herning Fjord and the Gipsdalen Formations may be biased by sedimentary inclination error but are consistent with a northward drift of East Greenland of about 10° from the arid (ca. 25° N) to semihumid (ca. 35° N) paleoclimatic belts in the Middle to Late Triassic. Seven normal and reversed polarity intervals are clearly delineated in the Fleming Fjord Formation section. A preferred correlation of the magnetostratigraphy to a cyclostratigraphically calibrated reference polarity sequence recently derived from drill cores in the Newark Basin of eastern North America suggests that the sampled interval represents about a 3.5 m.y. interval of the late Norian. The Malmros Klint Member and the overlying Carlsberg Fjord beds have composite sedimentary cycles that vary in thickness from 25 m to about 1 m and seem to match Milankovitch orbital climatic cyclicity with periods of ~400ky, ~100ky, ~40ky, and ~20ky. The composition and thickness ratio of the cycles suggest that the measured section of the Malmros Klint Member and the Carlsberg Fjord beds represents lacustrine accumulation over about 4 m.y., a duration consistent with the magnetostratigraphic correlations

Northward dispersal of dinosaurs from Gondwana to Greenland at the mid-Norian (215–212 Ma, Late Triassic) dip in atmospheric pCO2

The earliest dinosaurs (theropods and sauropodomorphs) are found in fossiliferous early Late Triassic strata dated to about 230 million years ago (Ma), mainly in northwestern Argentina and southern Brazil in the Southern Hemisphere temperate belt of what was Gondwana in Pangea. Sauropodomorphs, which are not known for the entire Triassic in then tropical North America, eventually appear 15 million years later in the Northern Hemi- sphere temperate belt of Laurasia. The Pangea supercontinent was traversable in principle by terrestrial vertebrates, so the main barrier to be surmounted for dispersal between hemispheres was likely to be climatic; in particular, the intense aridity of tropical desert belts and unstable climate in the equatorial humid belt accompanying high atmospheric pCO2 that characterized the Late Triassic. We revisited the chronostratigraphy of the dinosaur- bearing Fleming Fjord Group of central East Greenland and, with additional data, produced a correlation of a detailed magnetostra- tigraphy from more than 325 m of composite section from two field areas to the age-calibrated astrochronostratigraphic polarity time scale. This age model places the earliest occurrence of sauro- podomorphs (Plateosaurus) in their northernmost range to ∼214 Ma. The timing is within the 215 to 212 Ma (mid-Norian) window of a major, robust dip in atmospheric pCO2 of uncertain origin but which may have resulted in sufficiently lowered climate barriers that facilitated the initial major dispersal of the herbivorous sau- ropodomorphs to the temperate belt of the Northern Hemisphere. Indications are that carnivorous theropods may have had dis- persals that were less subject to the same climate constraints

Planetary chaos and inverted climate phasing in the Late Triassic of Greenland

Sedimentological records provide the only accessible archive for unraveling Earth’s orbital variations in the remote geological past. These variations modulate Earth’s cli- mate system and provide essential constraints on gravitational parameters used in solar system modeling. However, geologic documentation of midlatitude response to orbital climate forcing remains poorly resolved compared to that of the low-latitude tropics, especially before 50 Mya, the limit of reliable extrapolation from the present. Here, we compare the climate response to orbital variations in a Late Triassic midlatitude tem- perate setting in Jameson Land, East Greenland (∼43°N paleolatitude) and the tropical low paleolatitude setting of the Newark Basin, with independent time horizons pro- vided by common magnetostratigraphic boundaries whose timing has been corrobo- rated by uranium-lead (U-Pb) zircon dating in correlative strata on the Colorado Plateau. An integrated cyclostratigraphic and magnetostratigraphic age model revealed long-term climate cycles with periods of 850,000 and 1,700,000 y ascribed to the Mars–Earth grand orbital cycles. This indicates a 2:1 resonance between modulation of orbital obliquity and eccentricity variations more than 200 Mya and whose periodicities are inconsistent with astronomical solutions and indicate chaotic diffusion of the solar system. Our findings also demonstrate antiphasing in climate response between low and midlatitudes that has implications for precise global correlation of geological records

Triassic lithostratigraphy of the Jameson Land Basin (central East Greenland), with emphasis on the new Fleming Fjord Group

The lithostratigraphy of the Triassic deposits of the Jameson Land Basin in central East Greenland is revised. The new Scoresby Land Supergroup is now composed of the Wordie Creek, Pingo Dal, Gipsdalen and Fleming Fjord Groups. This paper only deals with the lithostratigraphy of the late Early-Late Triassic continental deposits of the latter three groups with emphasis on the vertebrate- bearing Fleming Fjord Group. The new Pingo Dal Group consists of three new formations, the Rødstaken, Paradigmabjerg and Klitdal Formations (all elevated from members), the new Gipsdalen Group consists of three new formations, the Kolledalen, Solfaldsdal (with the new Gråklint Member) and Kap Seaforth Formations (all elevated from members), and the new Fleming Fjord Group is subdivided into three new formations, the Edderfugledal, Malmros Klint and Ørsted Dal Formations (all elevated from members). The Edderfugledal Formation contains two cyclic bedded, lacustrine members, a lowermost Sporfjeld Member (elevated from beds), and an uppermost Pingel Dal Member (elevated from beds). The lacustrine red beds of the Malmros Klint Formation are not subdivided. The lacustrine and fluvial Ørsted Dal Formation contains three new members. In the eastern and central part of the basin, the formation is initiated by cyclic bedded, red lacustrine mudstones of the Carlsberg Fjord Member (elevated from beds), while in the northwestern part of the basin the lowermost part of the formation is composed of grey fluvial conglomerates and sandstones with subordinate red mudstones of the Bjergkronerne Member (elevated from beds). The uppermost part of the formations in most of the basin is composed of cyclic bedded, variegated lacustrine mudstones and grey to yellowish marlstones of the Tait Bjerg Member (elevated from beds). The sediments in the Fleming Fjord Group contain remains of a rich and diverse vertebrate fauna including dinosaurs, amphibians, turtles, aeotosaurs, pterosaurs, phytosaurs and mammaliaforms. Most vertebrate bones have been found in uppermost Malmros Klint Formation, and in the Carlsberg Fjord and Tait Bjerg Members. The Norian–early Rhaetian, lacustrine Fleming Fjord Group was deposited at about 41° N on the northern part of the supercon- tinent Pangaea. Lacustrine sedimentation was controlled by seasonal as well as longer-term (orbital) variation in precipitation. Precipitation was probably brought to the basin by southwesterly winds. The lacustrine sediments of the uppermost Fleming Fjord Group show deposition during increasingly humid conditions changing the lake environment from an ephemeral lake-steppe area to a peren- nial lake. This evolution of lake environment suggests a change from a winter-wet temperate climate to one with precipitation throughout the year

A Growth Curve Model with Fractional Polynomials for Analysing Incomplete Time-Course Data in Microarray Gene Expression Studies

Identifying the various gene expression response patterns is a challenging issue in expression microarray time-course experiments. Due to heterogeneity in the regulatory reaction among thousands of genes tested, it is impossible to manually characterize a parametric form for each of the time-course pattern in a gene by gene manner. We introduce a growth curve model with fractional polynomials to automatically capture the various time-dependent expression patterns and meanwhile efficiently handle missing values due to incomplete observations. For each gene, our procedure compares the performances among fractional polynomial models with power terms from a set of fixed values that offer a wide range of curve shapes and suggests a best fitting model. After a limited simulation study, the model has been applied to our human in vivo irritated epidermis data with missing observations to investigate time-dependent transcriptional responses to a chemical irritant. Our method was able to identify the various nonlinear time-course expression trajectories. The integration of growth curves with fractional polynomials provides a flexible way to model different time-course patterns together with model selection and significant gene identification strategies that can be applied in microarray-based time-course gene expression experiments with missing observations

A new vertebrate fossil-bearing layer in the Rhætelv Formation (Kap Stewart Group) of central East Greenland: evidence of a Hettangian marine incursion into the continental Jameson Land Basin

The Kap Stewart Group (Rhaetian-Sinemurian, Triassic–Early Jurassic) of the Jameson Land Basin in central East Greenland has traditionally been regarded as a strictly continental unit with delta and perennial lake sediments. New finds of plesiosaur bone remain in a thin storm deposited sandstone bed in the middle part of the Rhætelv Formation of the Kap Stewart Group, however, indicates a likely period of marine influence. At the study area at the eastern margin of the basin, the Rhætelv Formation is 300-m thick and overlies unconformably the Norian Fleming Fjord Group. The bone-bearing sandstone occurs 190 m above the base of the group and is closely associated with black laminated mudstones; palynological investigation of three samples from these mudstones indicates that they are of a younger Hettangian age. The Hettangian was a relatively short stage (201.3–199.5 Ma) and elsewhere characterized by two episodes of sea-level highstands. Assuming that the marine incursion in the Jameson land Basin evidenced by the plesiosaur fossil remains took place during the youngest of these sea-level highstands, the bone-bearing bed of the Rhætelv Formation can be dated to 200 Ma and thereby gives the first numerical age constraint of this hitherto poorly dated succession

Genetic and environmental determinants of O6-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins

Background: Epigenetic inactivation of O6-methylguanine DNA-methyltransferase (MGMT) is associated with increased sensitivity to alkylating chemotherapeutic agents in glioblastoma patients. The genetic background underlying MGMT gene methylation may explain individual differences in treatment response and provide a clue to a personalized treatment strategy. Making use of the longitudinal twin design, we aimed, for the first time, to estimate the genetic contributions to MGMT methylation in a Danish twin cohort. Methods: DNA-methylation from whole blood (18 monozygotic (MZ) and 25 dizygotic (DZ) twin pairs) repeated 10 years apart from the Longitudinal Study of Aging Danish Twins (LSADT) were used to search for genetic and environmental contributions to DNA-methylation at 170 CpG sites of across the MGMT gene. Both univariate and bivariate twin models were applied. The intraclass correlations, performed on cross-sectional data (246 MZ twin pairs) from an independent study population, the Middle-Aged Danish Twins (MADT), were used to assess the genetic influence at each CpG site of MGMT for replication. Results: Univariate twin model revealed twelve CpG sites showing significantly high heritability at intake (wave 1, h2 > 0.43), and seven CpG sites with significant heritability estimates at end of follow-up (wave 2, h2 > 0.5). There were six significant CpG sites, located at the gene body region, that overlapped among the two waves (h2 > 0.5), of which five remained significant in the bivariate twin model, which was applied to both waves. Within MZ pair correlation in these six CpGs from MADT demarks top level of genetic influence. There were 11 CpGs constantly have substantial common environmental component over the 10 years. Conclusions: We have identified 6 CpG sites linked to the MGMT gene with strong and persistent genetic control based on their DNA methylation levels. The genetic basis of MGMT gene methylation could help to explain individual differences in glioblastoma treatment response and most importantly, provide references for mapping the methylation Quantitative Trait Loci (meQTL) underlying the genetic regulation.Peer reviewe

Lithological anomalies in a relict coastal dune : geophysical and paleoenvironmental markers

Author Posting. © American Geophysical Union, 2007. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 34 (2007): L09707, doi:10.1029/2007GL029767.Ground exposures of migration surfaces (slipfaces) of a relict Holocene coastal dune along the southeastern Baltic Sea coast provide an ideal opportunity for establishing the causes of prominent reflections on geophysical profiles. High-amplitude reflections on high-resolution ground-penetrating radar (GPR) images correlate well with two major lithological anomalies: 1) paleosols developed on dune slipfaces, and 2) slipfaces consisting of heavy-mineral concentrations (HMCs). Paleosols serve as indicators of dune stability, represent datable chronostratigraphic surfaces, and help reconstruct dune paleo-morphology. HMCs have substantially higher magnetic susceptibility values than background quartz-rich sands and, where they are well-developed, can be also used for spatial correlation. Based on their occurrence at the study site, these enriched horizons likely represent periods of increased wind activity (storminess). Multiple HMCs upwind of paleosol P1 (800–670 cal years BP) likely reflect periods of intensified wind activity along the southeast Baltic region during the Medieval Warm Period.This research was funded by the Ocean and Climate Change Institute and The J. Lamar Worzel Assistant Scientist Fund of the Woods Hole Oceanographic Institution