Critical Flavor Number in the Three Dimensional Thirring Model

We present results of a Monte Carlo simulation of the three dimensional Thirring model with the number of fermion flavors N_f varied between 2 and 18. By identifying the lattice coupling at which the chiral condensate peaks, simulations are be performed at couplings g^2(N_f) corresponding to the strong coupling limit of the continuum theory. The chiral symmetry restoring phase transition is studied as N_f is increased, and the critical number of flavors estimated as N_{fc}=6.6(1). The critical exponents measured at the transition do not agree with self-consistent solutions of the Schwinger-Dyson equations; in particular there is no evidence for the transition being of infinite order. Implications for the critical flavor number in QED_3 are briefly discussed.Comment: 4 pages, 5 figure

Low-dose 2-Deoxy Glucose Stabilises Tolerogenic Dendritic Cells and Generates Potent in vivo Immunosuppressive Effects

Open Access via Springer Compact Agreement University of Aberdeen Development Trust Grant number RG14251, RG12663 Acknowledgements: We thank the University of Aberdeen Iain Fraser Flow Cytometry core facility, and the University of Aberdeen Histology and Microscopy core facility for processing of histology slides. The authors thank University of Aberdeen Medical Research Facility for technical assistance with in vivo experiments. We thank Dr. Tian Yu, Dr. Yi-Hsia Liu, Mrs Rosemary Fordyce, and Mrs Elizabeth Muckersie for technical assistance with in vivo and in vitro experiments. Funding: This work was supported by funds from the University of Aberdeen Development Trust Grants RG14251 and RG12663. Maria Christof was the recipient of a University of Aberdeen PhD Studentship. Samantha Le Sommer was funded by a Wellcome Trust ISSF Postdoctoral Fellowship.Peer reviewedPublisher PD

The atypical chemokine receptor-2 fine-tunes the immune response in herpes stromal keratitis

Herpes stromal keratitis (HSK) is a blinding corneal disease caused by herpes simplex virus-1 (HSV-1), a common pathogen infecting most of the world’s population. Inflammation in HSK is chemokine-dependent, particularly CXCL10 and less so the CC chemokines. The atypical chemokine receptor-2 (ACKR2) is a decoy receptor predominantly for pro-inflammatory CC chemokines, which regulates the inflammatory response by scavenging inflammatory chemokines thereby modulating leukocyte infiltration. Deletion of ACKR2 exacerbates and delays the resolution of the inflammatory response in most models. ACKR2 also regulates lymphangiogenesis and mammary duct development through the recruitment of tissue-remodeling macrophages. Here, we demonstrate a dose-dependent upregulation of ACKR2 during corneal HSV-1 infection. At an HSV inoculum dose of 5.4 x 105 pfu, but not at higher dose, ACKR2 deficient mice showed prolonged clinical signs of HSK, increased infiltration of leukocytes and persistent corneal neovascularization. Viral clearance and T cell activation were similar in ACKR2-/- and wild type mice, despite a transient diminished expression of CD40 and CD86 in dendritic cells. The data suggest that ACKR2 fine-tunes the inflammatory response and the level of neovascularization in the HSK

Reducing Intrathecal Baclofen Related Infections: Service Evaluation and Best Practice Guidelines

Objectives: Intrathecal baclofen (ITB) pumps are an effective treatment for spasticity; however infection rates have been reported in 3–26% of patients in the literature. The multidisciplinary ITB service has been established at The National Hospital for Neurology and Neurosurgery, UCLH, Queen Square, London for over 20 years. Our study was designed to clarify the rate of infection in our ITB patient cohort and secondly, to formulate and implement best practice guidelines and to determine prospectively, whether they effectively reduced infection rates. / Methods: Clinical record review of all patients receiving ITB pre‐intervention; January 2013–May 2015, and following practice changes; June 2016–June 2018. / Results: Four of 118 patients receiving ITB during the first time period (3.4%, annual incidence rate of infection 1.4%) developed an ITB‐related infection (three following ITB pump replacement surgery, one after initial implant). Infections were associated with 4.2% of ITB‐related surgical procedures. Three of four pumps required explantation. Following change in practice (pre‐operative chlorhexidine skin wash and intraoperative vancomycin wash of the fibrous pocket of the replacement site), only one of 160 ITB patients developed infection (pump not explanted) in the second time period (0.6%, annual incidence rate 0.3%). The infection rate related to ITB surgical procedures was 1.1%. In cases of ITB pump replacement, the infection rate was reduced to 3.3% from 17.6%. / Conclusions: This study suggests that a straightforward change in clinical practice may lower infection rates in patients undergoing ITB therapy

New Nanostructured Carbon Coating Inhibits Bacterial Growth, but Does Not Influence on Animal Cells

An electrospark technology has been developed for obtaining a colloidal solution containing nanosized amorphous carbon. The advantages of the technology are its low cost and high performance. The colloidal solution of nanosized carbon is highly stable. The coatings on its basis are nanostructured. They are characterized by high adhesion and hydrophobicity. It was found that the propagation of microorganisms on nanosized carbon coatings is significantly hindered. At the same time, eukaryotic animal cells grow and develop on nanosized carbon coatings, as well as on the nitinol medical alloy. The use of a colloidal solution as available, cheap and non-toxic nanomaterial for the creation of antibacterial coatings to prevent biofilm formation seems to be very promising for modern medicine, pharmaceutical and food industries

Domain wall fermions for planar physics

In 2+1 dimensions, Dirac fermions in reducible, i.e. four-component representations of the spinor algebra form the basis of many interesting model field theories and effective descriptions of condensed matter phenomena. This paper explores lattice formulations which preserve the global U(2N) symmetry present in the massless limit, and its breakdown to U(N)xU(N) implemented by three independent and parity-invariant fermion mass terms. I set out generalisations of the Ginsparg-Wilson relation, leading to a formulation of an overlap operator, and explore the remnants of the global symmetries which depart from the continuum form by terms of order of the lattice spacing. I also define a domain wall formulation in 2+1+1d, and present numerical evidence, in the form of bilinear condensate and meson correlator calculations in quenched non-compact QED using reformulations of all three mass terms, to show that U(2N) symmetry is recovered in the limit that the domain-wall separation L tends to infinity. The possibility that overlap and domain wall formulations of reducible fermions may coincide only in the continuum limit is discussed