97 research outputs found
Interpretation of the Metamorphic Processes in Various Rock Types Using the Chemistry of Garnets (Selecka Mountain, Macedonia)
The garnets from the complex of Selecka Mountain could be divided in two groups on the basis of their chemical composition and zoning.
The garnets from muscovite-schist and amphibole-schist show characteristics typical for a growth in prograde metamorphic conditions up to the medium metamorphic grade.
Characteristics of the other garnets (from aplite granite, aplite veins and metabasite) suggest their formation in anatectic or highly metasomatic conditions. The inversion in chemical zoning, observed in some of them, is discussed and related to possible processes of growth
Mapping photonic entanglement into and out of a quantum memory
Recent developments of quantum information science critically rely on
entanglement, an intriguing aspect of quantum mechanics where parts of a
composite system can exhibit correlations stronger than any classical
counterpart. In particular, scalable quantum networks require capabilities to
create, store, and distribute entanglement among distant matter nodes via
photonic channels. Atomic ensembles can play the role of such nodes. So far, in
the photon counting regime, heralded entanglement between atomic ensembles has
been successfully demonstrated via probabilistic protocols. However, an
inherent drawback of this approach is the compromise between the amount of
entanglement and its preparation probability, leading intrinsically to low
count rate for high entanglement. Here we report a protocol where entanglement
between two atomic ensembles is created by coherent mapping of an entangled
state of light. By splitting a single-photon and subsequent state transfer, we
separate the generation of entanglement and its storage. After a programmable
delay, the stored entanglement is mapped back into photonic modes with overall
efficiency of 17 %. Improvements of single-photon sources together with our
protocol will enable "on demand" entanglement of atomic ensembles, a powerful
resource for quantum networking.Comment: 7 pages, and 3 figure
Conditional control of the quantum states of remote atomic memories for quantum networking
Quantum networks hold the promise for revolutionary advances in information
processing with quantum resources distributed over remote locations via
quantum-repeater architectures. Quantum networks are composed of nodes for
storing and processing quantum states, and of channels for transmitting states
between them. The scalability of such networks relies critically on the ability
to perform conditional operations on states stored in separated quantum
memories. Here we report the first implementation of such conditional control
of two atomic memories, located in distinct apparatuses, which results in a
28-fold increase of the probability of simultaneously obtaining a pair of
single photons, relative to the case without conditional control. As a first
application, we demonstrate a high degree of indistinguishability for remotely
generated single photons by the observation of destructive interference of
their wavepackets. Our results demonstrate experimentally a basic principle for
enabling scalable quantum networks, with applications as well to linear optics
quantum computation.Comment: 10 pages, 8 figures; Minor corrections. References updated. Published
at Nature Physics 2, Advanced Online Publication of 10/29 (2006
Modulation of nucleotide metabolism by picornaviruses
Viruses actively reprogram the metabolism of the host to ensure the availability of sufficient building blocks for virus replication and spreading. However, relatively little is known about how picornaviruses-a large family of small, non-enveloped positive-strand RNA viruses-modulate cellular metabolism for their own benefit. Here, we studied the modulation of host metabolism by coxsackievirus B3 (CVB3), a member of the enterovirus genus, and encephalomyocarditis virus (EMCV), a member of the cardiovirus genus, using steady-state as well as 13C-glucose tracing metabolomics. We demonstrate that both CVB3 and EMCV increase the levels of pyrimidine and purine metabolites and provide evidence that this increase is mediated through degradation of nucleic acids and nucleotide recycling, rather than upregulation of de novo synthesis. Finally, by integrating our metabolomics data with a previously acquired phosphoproteomics dataset of CVB3-infected cells, we identify alterations in phosphorylation status of key enzymes involved in nucleotide metabolism, providing insight into the regulation of nucleotide metabolism during infection
Potential use of fatty acid profiles of the adductor muscle of cockles (Cerastoderma edule) for traceability of collection site
Geographic traceability of seafood is key for controlling its quality and safeguarding consumers’
interest. The present study assessed if the fatty acid (FA) profile of the adductor muscle (AM) of
fresh cockles (Cerastoderma edule) can be used to discriminate the origin of specimens collected in
different bivalve capture/production areas legally defined within a coastal lagoon. Results suggest
that this biochemical approach holds the potential to trace sampling locations with a spatial
resolution <10 Km, even for areas with identical classification for bivalve production. Cockles further
away from the inlet, i.e. in areas exposed to a higher saline variation, exhibited lower levels of
saturated fatty acids, which are key for stabilizing the bilayer structure of cell membranes, and a
higher percentage of polyunsaturated fatty acids, which enhance bilayer fluidity. Results suggest that
the structural nature of the lipids present in the AM provides a stable fatty acid signature and holds
potential for tracing the origin of bivalves to their capture/production areas
Synthesis of Unsymmetrical Difluoromethylene Bisphosphonates
We demonstrate the use of the symmetrical diethyl(dimethyl)difluoromethylene bisphosphonate reagent for the synthesis of terminal and unsymmetrical difluoromethylene bisphosphonates, close analogues of biologically important molecules. The difference in reactivity of the methyl and ethyl groups in the symmetrical diethyl(dimthyl)difluoromethylene bisphosphonate is exploited in a stepwise demethylation-condensation sequence to functionalize either side of the reagent to allow the generation of a series of close bioisosteres of natural pyrophosphate molecules, including ADPr, CDP-glycerol and CDP-ribitol.</p
Erratum: A real world multicenter retrospective study on extramedullary disease from Balkan Myeloma Study Group and Barcelona University: Analysis of parameters that improve outcome (Haematologica (2020) 10:51 (201-208) DOI: 10.3324/haematol.2019.219295)
We have noticed an error in the progression-free survival of patients with extramedullary plasmacytoma in our article published in Haematologica in January 2020 (doi: HAEMATOL/2019/219295). The following sentence in the abstract: “Extramedullary plasmacytoma at relapse had the worst prognosis with a PFS of 13.6 months and overall survival of 11.4 months.” Should be replaced by: “Extramedullary plasmacytoma at relapse had the worst prognosis with a PFS of 9.1 months and overall survival of 11.4 months.” Likewise, on page 205, the following sentence: “However, if diagnosed at relapse, PFS and OS were 13.6 months and 11.4 months for EMP compared to 20.9 months (P=0.249) and 39.8 months (P=0.093) for PO, respectively (Table 2 and Figure 1).” Should be replaced by: “However, if diagnosed at relapse, PFS and OS were 9.1 months and 11.4 months for EMP compared to 20.9 months (P=0.249) and 39.8 months (P=0.093) for PO, respectively (Table 2 and Figure 1).” The error was also present in Table 2. The corrected Table 2 is shown below. © 2021 Ferrata Storti Foundatio
Viability measurements after 6-MP or CPU treatment.
A) A representative MTS assay performed in parallel with the luciferase assay depicted in Fig 3A (mean ± SD). The cells were exposed to the different 6-MP concentrations for either 6h or 24h after which a MTS assay was used to determine the viability of the cells. B) A representative MTS assay performed in parallel with the luciferase assay depicted in Fig 3E (mean ± SD). The cells were exposed to the different CPU concentrations for either 6h or 24h after which a MTS assay was used to determine the viability of the cells. (TIF)</p
Inhibition of nucleotide salvage constraints CVB3 virus production early in infection.
Growth kinetics of CVB3 in HeLa R19 cells in the presence of different concentrations of 6-MP (A, B) or CPU (C, D). The cells were infected, treated with the compounds directly after infection, lysed at 2, 4, 6, or 10 hpi and titrated on HeLa R19 cells to determine the TCID50/ml (MOI 5; mean ± SEM of triplicates; one experiment). Guanidine hydrochloride (GuaHCl) is a known replication inhibitor. A,C) Growth curve of all the included time points. B,D) Bar graph of the 4h time point. A two-way ANOVA was performed, but results are not significant. (TIF)</p
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