3,231 research outputs found

    Aspects of Study of the 20th Century Naive Art in Russia: Researchers, Collections and Names

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    This article explores the main stages of the study of naive art in Russia, starting from the first decades of the 20th century and till the 1980s, when naive art was called an “amateur art”. This is the period of IZORAM (Saint Petersburg Art Workshops of Working Youth) activity and the long work of the National University of Extramural Studies. The first amateur art exhibitions took place in the 1970s, later leading to the establishment of specialized collections. In the 1980s, academic research into naive art began to filter through the image of a primitive, or so-called “third”, culture supposed to exist between “high” and “grassroots” art. Only since the 1990s has naive art begun to be perceived as a separate artistic movement. In Russian art criticism, naive art was defined as one of the primitive art areas of the eighteenth to twentieth centuries. During this period, separate museum collections began to take shape in Moscow including a private museum of outsider art, where some works by naive artists were presented, and the Municipal Museum of Naive Art. In Ekaterinburg, Gamayun Municipal Center for Folk Art and Crafts began to study naive art in 1994. In the 2000s, interest in the naive art of the 20th century began to grow. At this time, public and private collections of naive art were being formed in the following museums: B.U.Kashkin Museum at the Ural State University; Soviet Naive Art Museum; and Museum of Naive Art, which in 2015 became the part of the Yekaterinburg Museum of Fine Arts. Keywords: primitive art, amateur art, naive art, folk art, outsider art

    Study of rapitalam influence on oxotremorine-induced tremor

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    Of the article is to study Rapitalam influence on the oxotremorine-induced tremor in rat

    Assessment of the DNA damage level in peripheral blood leukocytes of mice treated orally with Rapitalam in acute and therapeutic doses

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    Centre there was performed experimental research, which carried out the identification and quantitative assessment of alkali-labile sites and DNA strand breaks in leukocytes of peripheral blood of male mice treated with Rapitalam. The method is based on the assessment of the integrity of DNA in leukocytes of the whole blood of animals. Rapitalam was administered to animals orally according to 2 schemes: a single acute dose (413 mg/kg, which corresponds to 1/5 LD50 dose) and once daily in a therapeutic dose (3 mg/kg) for 4 day

    Humanitarian “Reversing” in the Education Development in the Russian Federation Education under the Conditions of Transhumanistic Challenges in the Era of Globalisation

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    The effectiveness of the development of individual countries within the conditions of accelerating scientific and technological progress, expanding the influence of globalisation and integration processes in the global socio-cultural space are very important during the exchange of international students. The purpose of the paper is to research the methodological foundations of the humanities education for international students as an alternative to transhumanist ideology. In the framework of general scientific research methods, a paradigmatic approach is used as a factor analysis of students' educational processes. Particular attention is paid to the substantiation of the methodological foundations of the education humanisation on the basis of modern ontologically anthropological and religious-anthropological achievements of the philosophical field of knowledge. In this regard, the thesis is accepted that the artificially imposed transhumanist ideology performs a key integrating function when considering the practice of education of international students. The novelty of the study is due to a discussion of the contradictions caused by all-round technocratisation and informatisation, the fall of moral standards, and the degradation of human behavior. The practical significance of the study is determined by the need to develop a different pedagogy and model of education for modern students

    Pharmacokinetic studies of new antiparkinsonian drug Rapitalam

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    The aim of this study was to investigate the pharmacokinetic parameters of the mGluR4 receptor blocker Rapitalam on rabbits. There was developed the method of the quantitative determination of Rapitalam in the blood plasma of rabbits using high performance liquid chromatography with tandem mass spectrometric detection. The study was performed on 12 rabbits (males, weighing between 3,300 to 3,500 g). In intragastric dosing of the substance was administered using a gastric tube in the form of suspension in water 0.9 mg/ml, 9 mg/ml, and 90 mg/ml at a dose of 0.3 mg/kg, 3 mg/kg and 30 mg/kg. The main pharmacokinetic parameters of the substance was established on rabbits that allow you to optimize the future use of it's as a potential drug for the treatment of Parkinson's diseas

    Peculiarities of polyneuropathy in the peripheral t-cell lymphoma with cytostatics

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    This paper presents data on the occurrence and form of polyneuropathy in the peripheral T-cell lymphoma, and its main pathogenesis elements. Here the toxic effects of cytotoxic drugs and their role in the impairment of the nervous system have been describe

    The possibility of administration of glutamate receptors antagonists in the treatment of parkinson's disease

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    Parkinson's disease is the slow-progressing chronic neurodegenerative disease. Modern medicine has not yet found methods of curing disease, however, the existing methods of conservative and surgical treatment significantly improve the patient’s quality of life and slow the progression of the diseas

    The definition of specific antiparkinsonian effects of Rapitalam

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    Previously, we identified a metabotropic glutamate receptor 4 (mGluR4) as a potential target for drugs and predicted that activation of mGluR4 could provide a palliative advantage in the treatment of Parkinson's disease. Determine the mechanism of action of Rapitalam in vitro on a cell culture with mGluR4 over expression. The HEK293T cell line expressing human mGluR4 was used in the wor

    Novel mGluR4 agonist Rapitalam ameliorates motor dysfunction in mice with tau-associated neurodegeneration

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    Tau protein is classically involved in the pathogenesis of a neurodegenerative processes, such as Parkinson’s disease. This study was aimed at testing the novel mGluR4 selective agonist using it in transgenic mice with tau-associated neurodegeneratio
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