Comparison on Efficacy and Safety of Linagliptin Vs. Sitagliptin Among Type 2 Diabetic Patients.

AIM: The present study was to compare the efficacy and safety of linagliptin with that of sitagliptin among type 2 diabetic patients. OBJECTIVE: To assess the comparative efficacy of the DPP-4 inhibitors linagliptin/sitagliptin through, Fasting plasma glucose (FPG), post prandial glucose (PPG) and glycated haemoglobin (HbA1c) levels along with lipid profile and BMI measure in a period of 6 months. � To evaluate and compare the safety of the linagliptin/sitagliptin drugs by following the assessment of renal profile, hepatic profile (Liver Function Test). PLAN OF WORK: The present dissertation work was planned to conduct a “comparative study on efficacy and safety of linagliptin vs. sitagliptin drugs in the treatment of type 2 diabetes mellitus”. And was planned to conduct in Annamalai diabetic research center at Karaikudi. CONCLUSION: The results from the comparative study to evaluate the efficacy and safety of linagliptin and sitagliptin drugs. � The present study shows that two drugs such as linagliptin and sitagliptin reduced the fasting plasma glucose, post prandial plasma glucose and glycosylated haemoglobin level. But the linagliptin provided superior control of glycemic as compare to sitagliptin. There were no significant changes in BMI on both drugs.So linagliptin and sitagliptin had good body weight control. There were favorable changes in lipid profiles in that linagliptin more favorable than sitagliptin. Our study shows that insignificance of renal (Sr.Cr, BU, SUA) and hepatic (TB, ALT, AST) profile. So both drugs were considered to be more safe. It can be concluded with the results of the present study linagliptin possesses greater efficacy with increased glycemic control and good safety compared to sitagliptin in Type 2 diabetic patients

Crumpled sheet like graphene based WO3-Fe2O3 nanocomposites for enhanced charge transfer and solar photocatalysts for environmental remediation

The combination of two or more metal oxides onto graphene sheets with even distribution is projected to enhanced charge transfer properties in photocatalytic applications. We report, tungsten oxide (WO3) with iron oxide (Fe2O3) nanoparticles grown on graphene sheets via a facile economical one pot hydrothermal method and consequently characterized by standard analytical techniques. Synthesized Fe2O3 with WO3 nanoparticles were well ornamented on surface of the graphene sheets which have a significant charge transfer properties. The resulting hybrid WO3-Fe2O3-rGO (WFG) nanocomposites showed enhanced photocatalytic, heavy metal removal and antibacterial activities. The superior photocatalytic removal efficiencies were observed for the removal of rhodamine B (∼94%) and methylene blue dyes (∼98%) under solar light irradiation. The antibacterial activity of WFG nanocomposites were performed against Escherichia coli (E.coli) and Staphylococcus aureus (S.aureus) as models for Gram-negative and Gram-positive bacteria. The outcome of the results have an intellectual effect on the use of WFG nanocomposites to address the upcoming energy and environment issues

Scavenging methyl orange dye from aqueous solution using an effective low-cost activated carbon prepared from delonix Regia seeds

631-636An increasing textile industry has exacerbated the serious problem of dealing with industrial effluent that contains toxic dye molecules. Despite the development of various techniques for adsorbing dyes in wastewater, many researchers have yet to expand a highly efficient technique for the revival of dye molecules from textile waste water. However, adsorption techniques using low cost, eco-friendly, effective adsorbents are extensively used due to their simplicity and good efficiency. A novel approach for the capture of dye molecules using a composite inexpensive activated carbon (AC) adsorbent synthesized from Gulmohar (GM) plant seeds has been proposed in this study. Prepared AC before and after adsorption of Methyl Orange (MO) has been characterized by SEM, EDX and FT-IR. Experimental adsorption data of chosen anionic dyes fits several kinetic and isotherm models. Kinetic studies reveal that a pseudo-second order is the mainly suitable model in the adsorption process. The equilibrium adsorption data of anionic dye show that the system followed the Langmuir adsorption isotherm. In addition, through thermodynamic calculations the negative value of ΔG° and negative value of ΔH° show that the adsorption is a spontaneous and exothermic process. All the above results conclude that the GMAC can be used as an effective absorbent for removing dyes from wastewater

Scavenging methyl orange dye from aqueous solution using an effective low-cost activated carbon prepared from delonix Regia seeds

An increasing textile industry has exacerbated the serious problem of dealing with industrial effluent that contains toxic dye molecules. Despite the development of various techniques for adsorbing dyes in wastewater, many researchers have yet to expand a highly efficient technique for the revival of dye molecules from textile waste water. However, adsorption techniques using low cost, eco-friendly, effective adsorbents are extensively used due to their simplicity and good efficiency. A novel approach for the capture of dye molecules using a composite inexpensive activated carbon (AC) adsorbent synthesized from Gulmohar (GM) plant seeds has been proposed in this study. Prepared AC before and after adsorption of Methyl Orange (MO) has been characterized by SEM, EDX and FT-IR. Experimental adsorption data of chosen anionic dyes fits several kinetic and isotherm models. Kinetic studies reveal that a pseudo-second order is the mainly suitable model in the adsorption process. The equilibrium adsorption data of anionic dye show that the system followed the Langmuir adsorption isotherm. In addition, through thermodynamic calculations the negative value of ΔG° and negative value of ΔH° show that the adsorption is a spontaneous and exothermic process. All the above results conclude that the GMAC can be used as an effective absorbent for removing dyes from wastewater

Achieving Deep Cuts in the Carbon Intensity of U.S. Automobile Transportation by 2050: Complementary Roles for Electricity and Biofuels

Passenger cars in the United States (U.S.) rely primarily on petroleum-derived fuels and contribute the majority of U.S. transportation-related greenhouse gas (GHG) emissions. Electricity and biofuels are two promising alternatives for reducing both the carbon intensity of automotive transportation and U.S. reliance on imported oil. However, as standalone solutions, the biofuels option is limited by land availability and the electricity option is limited by market adoption rates and technical challenges. This paper explores potential GHG emissions reductions attainable in the United States through 2050 with a county-level scenario analysis that combines ambitious plug-in hybrid electric vehicle (PHEV) adoption rates with scale-up of cellulosic ethanol production. With PHEVs achieving a 58% share of the passenger car fleet by 2050, phasing out most corn ethanol and limiting cellulosic ethanol feedstocks to sustainably produced crop residues and dedicated crops, we project that the United States could supply the liquid fuels needed for the automobile fleet with an average blend of 80% ethanol (by volume) and 20% gasoline. If electricity for PHEV charging could be supplied by a combination of renewables and natural-gas combined-cycle power plants, the carbon intensity of automotive transport would be 79 g CO2e per vehicle-kilometer traveled, a 71% reduction relative to 2013

Thermal resistance of fibre-fabric combinations in convective environments

49-53<span style="font-size:11.0pt;line-height:115%; font-family:" calibri","sans-serif";mso-ascii-theme-font:minor-latin;mso-fareast-font-family:="" calibri;mso-fareast-theme-font:minor-latin;mso-hansi-theme-font:minor-latin;="" mso-bidi-font-family:"times="" new="" roman";mso-ansi-language:en-us;mso-fareast-language:="" en-us;mso-bidi-language:ar-sa"="">Combined fibre-fabric assemblies of fibres of different deniers and fabrics of different covers have been evaluated for their thermal resistance in convective environments. It has been found that fibre-fabric assemblies are more effective than fibre webs alone in these environments and the fabrics with higher cover perform better than the fabrics with lower cover.</span