The Effect of the Association between Donepezil and Choline Alphoscerate on Behavioral Disturbances in Alzheimer's Disease: Interim Results of the ASCOMALVA Trial

BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are a group of psychological reactions, psychiatric symptoms, and behaviors commonly found in Alzheimer's disease (AD). Four clusters of BPSD have been described: mood disorders (depression, anxiety, and apathy), psychotic symptoms (delusions and hallucinations), aberrant motor behaviors (pacing, wandering, and other purposeless behaviors), and inappropriate behaviors (agitation, disinhibition, and euphoria). Most of them are attributed to acetylcholine deficiency. OBJECTIVE: To evaluate if a higher amount of acetylcholine obtained by associating donepezil and choline alphoscerate might have a favorable effect on BPSD. METHODS: BPSD were measured at baseline and after 24 months in 113 mild/moderate AD patients, included in the double-blind randomized trial ASCOMALVA, by the Neuropsychiatric Inventory (NPI). Two matched groups were compared: group A treated with donepezil (10 mg/day) plus choline alphoscerate (1200 mg/day), and group B treated with donepezil (10 mg/day) plus placebo. RESULTS: Data of NPI revealed a significant decrease of BPSD severity and distress of the caregiver in patients of group A compared with group B. Mood disorders (depression, anxiety and apathy) were significantly decreased in subjects treated with donepezil and choline alphoscerate, while their severity and frequency was increased in the other group. CONCLUSIONS: Patients treated with donepezil plus choline alphoscerate showed a lower level of behavioral disturbances than subjects treated with donepezil only, suggesting that the association can have beneficial effect

Construction and Analysis of Projected Deformed Products

We introduce a deformed product construction for simple polytopes in terms of lower-triangular block matrix representations. We further show how Gale duality can be employed for the construction and for the analysis of deformed products such that specified faces (e.g. all the k-faces) are ``strictly preserved'' under projection. Thus, starting from an arbitrary neighborly simplicial (d-2)-polytope Q on n-1 vertices we construct a deformed n-cube, whose projection to the last dcoordinates yields a neighborly cubical d-polytope. As an extension of thecubical case, we construct matrix representations of deformed products of(even) polygons (DPPs), which have a projection to d-space that retains the complete (\lfloor \tfrac{d}{2} \rfloor - 1)-skeleton. In both cases the combinatorial structure of the images under projection is completely determined by the neighborly polytope Q: Our analysis provides explicit combinatorial descriptions. This yields a multitude of combinatorially different neighborly cubical polytopes and DPPs. As a special case, we obtain simplified descriptions of the neighborly cubical polytopes of Joswig & Ziegler (2000) as well as of the ``projected deformed products of polygons'' that were announced by Ziegler (2004), a family of 4-polytopes whose ``fatness'' gets arbitrarily close to 9.Comment: 20 pages, 5 figure

Constructing Delaunay triangulations along space-filling curves

Incremental construction con BRIO using a space-filling curve order for insertion is a popular algorithm for constructing Delaunay triangulations. So far, it has only been analyzed for the case that a worst-case optimal point location data structure is used which is often avoided in implementations. In this paper, we analyze its running time for the more typical case that points are located by walking. We show that in the worst-case the algorithm needs quadratic time, but that this can only happen in degenerate cases. We show that the algorithm runs in O(n logn) time under realistic assumptions. Furthermore, we show that it runs in expected linear time for many random point distributions. This research was supported by the Deutsche Forschungsgemeinschaft within the European graduate program ’Combinatorics, Geometry, and Computation’ (No. GRK 588/2) and by the Netherlands’ Organisation for Scientific Research (NWO) under BRICKS/FOCUS grant number 642.065.503 and project no. 639.022.707

On polyhedral projection and parametric programming

Submitted versio

Politics of nanotechnologies in food and agriculture

The chapter discusses the reasons for the delay in the regulatory intervention concerning nanotechnologies used in the agriculture and food sectors. The main finding is that unregulated introduction of nanoinnovation into the food system is due to the current neoliberal food policy and to the power struggles that characterize the economic, social and political dynamics within the global supply chain. Therefore, it is necessary to put the ‘question concerning technology’ at the center of the regulatory debate in order to implement a regulatory system able to face nanorisks. Which means looking at the way in which technology controls power relationships within society. Attention should be shifted from efficiency to power issues, and new technologies should be assessed from a political rather than an economic or ethical perspective

Mother and Daughter Carrying of the Same Pathogenic Variant in FGFR2 with Discordant Phenotype

Craniosynostosis are a heterogeneous group of genetic conditions characterized by the premature fusion of the skull bones. The most common forms of craniosynostosis are Crouzon, Apert and Pfeiffer syndromes. They differ from each other in various additional clinical manifestations, e.g., syndactyly is typical of Apert and rare in Pfeiffer syndrome. Their inheritance is autosomal dominant with incomplete penetrance and one of the main genes responsible for these syndromes is FGFR2, mapped on chromosome 10, encoding fibroblast growth factor receptor 2. We report an FGFR2 gene variant in a mother and daughter who present with different clinical features of Crouzon syndrome. The daughter is more severely affected than her mother, as also verified by a careful study of the face and oral cavity. The c.1032G>A transition in exon 8, already reported as a synonymous p.Ala344 = variant in Crouzon patients, also activates a new donor splice site leading to the loss of 51 nucleotides and the in-frame removal of 17 amino acids. We observed lower FGFR2 transcriptional and translational levels in the daughter compared to the mother and healthy controls. A preliminary functional assay and a molecular modeling added further details to explain the discordant phenotype of the two patients

Comparative analysis of medicinal plants used in traditional medicine in Italy and Tunisia

<p>Abstract</p> <p>Background</p> <p>Italy and Tunisia (Africa for the Romans), facing each other on the opposite sides of the Mediterranean Sea, have been historically linked since the ancient times. Over the centuries both countries were mutually dominated so the vestiges and traces of a mutual influence are still present. The aim of the present study is to conduct a comparative analysis of the medicinal species present in the respective Floras in order to explore potential analogies and differences in popular phytotherapy that have come out from those reciprocal exchanges having taken place over the centuries</p> <p>Methods</p> <p>The comparative analysis based on the respective floras of both countries takes into consideration the bulk of medicinal species mutually present in Italy and Tunisia, but it focuses on the species growing in areas which are similar in climate. The medicinal uses of these species are considered in accordance with the ethnobotanical literature.</p> <p>Results</p> <p>A list of 153 medicinal species belonging to 60 families, present in both floras and used in traditional medicine, was drawn. A considerable convergence in therapeutic uses of many species emerged from these data.</p> <p>Conclusion</p> <p>This comparative analysis strengthens the firm belief that ethno-botanical findings represent not only an important shared heritage, developed over the centuries, but also a considerable mass of data that should be exploited in order to provide new and useful knowledge.</p

Economia, organizzazioni criminali e corruzione

L\u2019economia \ue8 la scienza che osserva il comportamento umano di fronte alla scarsit\ue0; e la corruzione \ue8 assai spesso la strada pi\uf9 redditizia per procurarsi risorse scarse. L\u2019organizzazione \ue8 la scienza che studia le forme razionali di divisione e coordinamento del lavoro umano; e la corruzione ha bisogno del supporto di forme efficaci di organizzazione del lavoro umano, legale o criminale che sia, per essere realizzata. L\u2019analisi dei saggi contenuti nel volume sostiene la tesi che tra il fenomeno della corruzione e i fenome- ni economici e organizzativi ci siano relazioni intense. Gli autori dei con- tributi sono economisti, sociologi, aziendalisti, giuristi, storici e statistici. Il lettore pertanto potr\ue0 farsi un\u2019idea del fenomeno della corruzione attingen- do a prospettive di analisi assai diverse tra di loro