Die Social Media Matrix - Orientierung für die Versicherungsbranche

Ziel dieser Arbeit ist es, Versicherungsunternehmen eine Orientierungshilfe in Social Media zu geben. Hierzu wird eine Kategorisierung der vielfältigen Web 2.0-Dienste geboten, die Social Media Matrix, die fünf wesentliche Social Media-Kategorien unterscheidet und hinsichtlich ihrer Eignung für Versicherungsunternehmen bewertet.This paper offers a guideline to social media to insurance companies. For this purpose the varied web 2.0 services are classified by the "Social Media Matrix" which differentiates between five main categories. Moreover the different web formats are evaluated concerning their suitability for insurance companies

Advances in cardiac rehabilitation: cardiac rehabilitation after transcatheter aortic valve implantation

Due to the demographic change and an aging population, the prevalence of the most frequent valve disease, aortic stenosis (AS), is still rising

Orthogonal Translation Meets Electron Transfer: In Vivo Labeling of Cytochrome c for Probing Local Electric Fields

Cytochrome c (cyt c), a redox protein involved in diverse fundamental biological processes, is among the most traditional model proteins for analyzing biological electron transfer and protein dynamics both in solution and at membranes. Studying the role of electric fields in energy transduction mediated by cyt c relies upon appropriate reporter groups. Up to now these had to be introduced into cyt c by in vitro chemical modification. Here, we have overcome this restriction by incorporating the noncanonical amino acid p-cyanophenylalanine (pCNF) into cyt c in vivo. UV and CD spectroscopy indicate preservation of the overall protein fold, stability, and heme coordination, whereas a small shift of the redox potential was observed by cyclic voltammetry. The C≡N stretching mode of the incorporated pCNF detected in the IR spectra reveals a surprising difference, which is related to the oxidation state of the heme iron, thus indicating high sensitivity to changes in the electrostatics of cyt c.Fil: Völler, Jan. Technishe Universitat Berlin; AlemaniaFil: Biava, Hernan Daniel. Technishe Universitat Berlin; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Koksch, Beate. Freie Universitä t Berlin; AlemaniaFil: Hildebrandt, Peter. Technishe Universitat Berlin; AlemaniaFil: Budisa, Nediljko. Technishe Universitat Berlin; Alemani

Transforming young adults’ climate learning and actions through a co-created climate communication retreat

This article brings climate communication approaches to transformational climate learning by critically evaluating an experimental climate communication retreat that brought 20 young adults from across Europe together in Austria to co-create climate communications as a constitutive dimension of climate action. Structured around the transformational principles of interdisciplinarity, multidimensionality, collaborative project-based learning, reflexivity and action-oriented, the retreat specifically focused upon the creative co-production, between peers, of climate communication as communicative meaning-making and action. The retreat experience transformed young people’s sociocultural understandings of climate change, and climate communication as meaning-making and action, and increased their self and group efficacy. The key factors contributing to these transformations were: the forging of collective identity, peer-to-peer learning, emotional sharing, reflexive spaces, inspiring learning environment, interdisciplinary learning, multidimensional experiences, and collaborative project-based communications. Situating co-created climate communication within transformational learning can help facilitate collective experiences beyond direct climate action participation, helping create education for social change

Management of high-risk patients with hypertension and left ventricular hypertrophy in Germany: differences between cardiac specialists in the inpatient and outpatient setting

BACKGROUND: Among patients with hypertension, those with established left ventricular hypertrophy (LVH) represent a high risk cohort with poor prognosis. We aimed to investigate differences in characteristics and health care management of such patients treated as inpatients or outpatients by cardiac specialists. METHODS: Prospective cross-sectional study in patients with hypertension and LVH who were referred to either inpatient care (rehabilitation hospitals) or to outpatient care (cardiology practices). RESULTS: A total of 6358 inpatients (59.6% males; mean age 66.6 years) and 2246 outpatients (59.5% males; mean age 63.2 years) were followed up for a mean of 23 vs. 52 days, respectively. Inpatients compared to outpatients had a significantly higher prevalence of coronary heart disease, history of stroke, renal failure or diabetes. Mean blood pressure of inpatients compared to outpatients was significantly lower both at entry (150/84 vs. 161/93 mmHg) and at end of follow-up (129/75 vs. 139/83 mmHg). After adjustment for baseline blood pressure and a propensity score, differences between out- and inpatients at end of follow-up were 8.0/5.1 mmHg in favour of inpatients. Blood pressure goals as specified by guidelines were not met by 32% of inpatients and 55% of outpatients. CONCLUSION: Inpatients had a higher rate of comorbidities and more advanced atherosclerotic disease than outpatients. Control of hypertension of inpatients was already better on admission than in outpatients, and treatment intensity in this group was also higher during the observation period. While blood pressure lowering was substantial in both groups, there were still a high proportion of patients who did not achieve treatment goals at discharge

NTNU-SINTEF SolarNet: A solar irradiation monitoring network at high latitudes

This study presents a monitoring network for solar irradiation at high latitudes, called NTNU-SINTEF SolarNet. The network collects, with a time resolution ranging from seconds to hours, solar irradiance data, e.g. global horizontal irradiation, diffuse horizontal irradiation, direct normal irradiation, global tilted irradiation, solar energy generation, which are required in solar irradiation modelling in built environments. The network will be used for specific applications, such as (i) anomalies detection, (ii) influences of ground albedo, and (iii) ageing/degradation of solar modules, that are described in this paper. Some characteristics that make the NTNU-SINTEF SolarNet relevant for solar energy research at high latitudes are identified: short distances among the sensors, the ease of data accessibility, the use of the same sensor typologies, and different solar module technologies. The research holds the potential to boost the solar energy digitalization, impacting on several aspects such as predictive and adaptive control strategies for energy management, design of renewable energy system, multi-scale optimization and efficient exploitation of solar energy.publishedVersio

Heterologous Expression and Engineering Studies of Labyrinthopeptins, Class III Lantibiotics from Actinomadura namibiensis

SummaryLabyrinthopeptins are class III lantibiotics produced by the actinomycete Actinomadura namibiensis. The most characteristic structural feature is the posttranslationally installed triamino triacid labionin with a quaternary α-carbon. In addition to the unique structure, labyrinthopeptin A2 possess remarkable antiviral and antiallodynic biological activities. To harness the substrate tolerance of the biosynthetic machinery, we developed an efficient system for the generation of labyrinthopeptin analogs. Streptomyces lividans was used as a heterologous host since the natural producer Actinomadura namibiensis remained genetically intractable. Generation of a library of 39 mutants allowed identification of variable and invariable regions in the labyrinthopeptin structures. Additional data on the flexibility of the biosynthetic machinery were provided by in vitro experiments. This study is detailed investigation on the potential to generate analogs of class III lantibiotics by genetic engineering