17 research outputs found
Benign Mesenchymoma of the Esophagus
Benign mesenchymoma is an extremely rare neoplasm mostly located in or about the kidney and is composed of a haphazard mixture of adult fat, fibrous tissue and tangled blood vessels, scattered nests or masses of smooth muscle cells, occasionally islands of cartilage, bone, and lymphoid tissue as well as other mesenchymal elements. Only two cases of benign mediastinal mesenchymomas were reported in the literature. In this report we describe a benign mesenchymoma of the mediastinum which presented itself with symptoms and signs of the traction diverticula of the esophagus. Copyright (C) 1997 Elsevier Science B.V.WoSScopu
Effects of recombinant alpha interferon on chronic active hepatitis B: preliminary results.
This paper presents the preliminary results of a study designed to evaluate the effects of alpha interferon in chronic hepatitis B. After six months' treatment with interferon alfa-2b (5 million units (MU), three times weekly) 15 of 25 (60%) patients achieved seroconversion of hepatitis B e antigen, 17 (68%) normalised alanine aminotransferase (ALT) activity, and 15 (60%) showed a decrease in the inflammatory reaction on liver histology. No seroconversions occurred in the control group (n = 10), and none of the control patients achieved a normal ALT or showed a reduction in the inflammatory reaction. Adverse effects were experienced by most patients who received interferon but none warranted stopping the treatment
Different response rates for wild type and precore mutant HBV to interferon (IFN) treatment
The use of desferrioxamine infusions to enhance the response rate to interferon α (IFN) treatment of chronic viral hepatitis
Human MLH1 deficiency predisposes to hematological malignancy and neurofibromatosis type 1
PubMedID: 9927033Heterozygous germ-line mutations in the DNA mismatch repair genes lead to hereditary nonpolyposis colorectal cancer. The disease susceptibility of individuals who constitutionally lack both wild-type alleles is unknown. We have identified three offspring in a hereditary nonpolyposis colorectal cancer family who developed hematological malignancy at a very early age, and at least two of them displayed signs of neurofibromatosis type 1 (NF1). DNA sequence analysis and allele-specific amplification in two siblings revealed a homozygous MLH1 mutation (C676T › Arg226Stop). Thus, a homozygous germ- line MLH1 mutation and consequent mismatch repair deficiency results in a mutator phenotype characterized by leukemia and/or lymphoma associated with neurofibromatosis type 1