7-Azabicyclo[2.2.1]heptane N-Imide as an Intermediate in the Thermal Decomposition of N-Amino-7-Azabicyclo[2.2.1]heptane and the Corresponding Benzenesulphonamide

An intermediate in the thermal decomposition of N-amino-7-azabicyclo[2.2.1]heptane and the corresponding benzenesulphonamide derivative, whose structure is consistent with the formulation 7-azabicyclo[2.2.1]heptane N-imide, affords on thermal fragmentation the hydrocarbon products hexa-1,5-diene, bicyclo[2.2.0]hexane, and cyclohexene and does not rearrange to the corresponding stable 2,3-diazabicyclo[2.2.2]oct-2-ene isomer

Characterizing a Novel Connection Between the Plant Hormones Cytokinin and Jasmonic Acid in Control of Maize Leaf Growth.

M.S. Thesis. University of Hawaiʻi at Mānoa 2018

Sue Uyehara

Sue Uyehara is a Louisiana native and a registered dietitian. She worked with the Women, Infants, and Children Program (WIC) in Louisiana, before relocating to Hawaii, where she works with the Office of Hawaii Child Nutrition Programs.https://egrove.olemiss.edu/icn_ohistories/1121/thumbnail.jp

No Place Like Homeskillet

The iconic Sunnyland breakfast spot, Homeskillet, closed after punctuating its ten-year run with a celebratory brunch party. Watch a community built around warm hospitality, hearty comfort food and eclectic decorations gather to bid farewell to a Bellingham favourite in this video feature story. To construct this six minute video, I pulled from my knowledge of storytelling through multimedia learned in my years at Western Washington University earning an English Creative Writing major, a journalism minor and participating in a film production club. This video feature story dwells within a smaller quadrant of journalism: feel-good journalism. Community and hospitality are at the heart of this story, as shown through several interviews with Bellinghamsters at the party who love the quirky restaurant not only for its food, but its boisterous owners Tina and Kirby White and eccentric nature. In its ten year run, Homeskillet demonstrated how a business and two passionate community members, with the help of their staff, can bring out the best in people and bind a community together around a hearty brunch. To convey this story and capture the character of Homeskillet and the Whites, a professional photographer and I attended the closing party on May 1st and pulled patrons aside for interviews and recorded b-roll for video footage as well. I wrote open questions that allowed interviewees to express their feelings about the restaurant, its staff and food, then followed the threads I found between their interviews and structured the video story from there. I edited the footage into the final product myself, harkening back to skill I acquired in my extracurricular filmmaking during my first couple of years in college. The final product is published on YouTube and was sent to the Whites to use as they please. It is a story of community joy, nurturing and iconic quirkiness

EPIGENETIC REGULATION OF GENE EXPRESSION BY ECDYSONE HORMONE SIGNALING

The development of a multicellular organism from a single progenitor is a complex process that involves the establishment of gene expression profiles specific to each stage and tissue. In Drosophila, pulses of the steroid hormone ecdysone play a central role in coordinating development events throughout the life cycle, including the larval molts and the onset of the larval-to-adult transition. The initial response to ecdysone is mediated by its receptor, EcR, which activates a series of downstream transcription factors that amplify and temporally progress the cascade. The genetic response has tissue- and temporal-specificity; each successive pulse initiates different developmental events in tissues throughout the animal. However, our understanding of how this specificity is achieved remains incomplete. In this work, we examined how EcR and one of its downstream transcription factors, E93, coordinate changes in gene expression. We found that changes in chromatin accessibility are a central means by which specificity to the response is achieved but that EcR and E93 have different roles. E93 is required to temporally progress the accessibility profile and binds many sites dependent on E93 for their accessibility, indicating that it may have pioneer-like activity. In contrast, EcR appears to be a passive factor in which tissue-specific differences in open chromatin direct its binding to different sites between the two tissues. Since EcR functions at the top of a transcriptional hierarchy, we further investigated its direct role in promoting changes in gene expression. We found that EcR plays a broad role in coordinating the response to ecdysone and that changes in its binding profile are an important means by which specificity is achieved. To determine the function of EcR binding, we investigated its role in regulating enhancer activity. As expected, we found that it regulates the temporal activity of enhancers. Unexpectedly, however, we also found that it regulates the spatial pattern of enhancers. This indicates that EcR may regulate gene expression differences that occur within tissues, as well as between them. Collectively, this work has provided new insights into how tissue- and temporal-specific gene expression responses can be generated by a single, extrinsic signal.Doctor of Philosoph

Modelo de gestión de incidentes para una entidad estatal

This article shows the development of an Incident Management Model based on ITIL v 3.0 that will allow the improvement of information technology services (TI) delivery, provided by the National Office of Electronic Government and Informatic (ONGEI). Due to the increase of requirements in the use of the TI services from other State entities (users), the current situation of ONGEI was analyzed in order to identify their incident management problems as well as the causes that originate them. In this way, it was identified that the severities were not foreseen, neither the response nor the restore times; it was also found the existence of duplication of registers, a new management model and the purchase of a new tool were proposed (Service Tonic, developed by a company with the same name) to adequately manage incidents and service management.  El presente artículo muestra la elaboración de un modelo de gestión de incidentes basado en ITIL v3.0, que permitirá mejorar la entrega de servicios de tecnologías de información (TI) ofrecidos por la Oficina Nacional de Gobierno Electrónico e Informática (ONGEI). Ante el incremento de los requerimientos en el uso de los servicios de TI por parte de otras entidades del estado (usuarios), se analizó la situación actual de la ONGEI para reconocer sus problemas en la gestión de incidentes, así como las causas que lo originan. De esta manera se identificó que no se abordaban las severidades, los tiempos de respuesta ni los de restauración; y así también se comprobó la existencia de duplicidad de registros. del servicio se propuso un nuevo modelo de gestión y la adquisición de una herramienta (ServiceTonic, elaborado por la empresa del mismo nombre) para gestionar adecuadamente los incidentes y la gestión de servicios. &nbsp

Mejora de procesos, bajo un nuevo marco de referencia, para la gestión de incidentes, en la DRELP

El presente trabajo de investigación entrega un nuevo marco de referencia para la mejora del proceso gestión de incidentes que da soporte a los servicios de Tecnologías de la Información (TI) en la Dirección Regional de Educación Lima-Provincias (DRELP), apoyándose en marcos de referencia como “Objetivos de Control para Información y Tecnologías Relacionadas” (COBIT), Biblioteca de Infraestructura de Tecnologías de Información (ITIL) y la Simulación de procesos; bajo este nuevo enfoque la investigación mejora los indicadores relevantes del proceso entregando tiempos óptimos de reposición que permiten dar continuidad a los procesos de negocio, basándose en la identificación del “Qué” para saber que parte del proceso requiere mejorarse y entregando el “Cómo” que implica aplicar las buenas prácticas de los diversos marcos de referencia en los cuales se apoya la investigación, siguiendo el enfoque ágil de proyectos para la obtención del resultados en plazos cortos que permitieron tener la retroalimentación de los involucrados en el soporte del proceso TI. La investigación entrega el marco necesario para continuar con la mejora de los otros procesos TI de la entidad que requieren ser mejorados, formalizados y en algunos casos implementados para dar soportar a los nuevos servicios TI que se implementen posteriormente