98 research outputs found
Secretin, a stimulus for duodenal and pancreatic "gastrin" release: Possible pathogenetic significance in Zollinger-Ellison (ZE) syndrome
Ex vivo hemoperfused pancreaticoduodenal preparations from dogs have been used to study intraluminal and circulatory patterns of release of immunoreactive gastrin under basal conditions and after secretin stimulation. Bidirectional release of immunoreactive gastrin was maximal at 3 U/min secretin infusion, and release into pancreatic and duodenal juice exceeded that into portal venous blood. Molecular sieving chromatography of peptides with gastrin-like immunoreactivity recovered from duodenal and pancreatic juice indicated a single species of a molecular size equivalent to CCK8 and smaller than minigastrin (G-14). The exact identity has not been defined. This study demonstrates that secretin stimulates release of gastrin-like peptides into blood and lumen of extra-antral gastrin-producing tissues in the dog. Unidirectional gastrin release patterns from gastrinoma tissue may explain the paradoxical increase in plasma gastrin levels in response to secretin in patients with gastrinomas (Zollinger-Ellison syndrome).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/23280/1/0000217.pd
On the interaction between intragastric pH and electrical vagal stimulation in causing gastric acid secretion and intraluminal release of gastrin and somatostatin in anesthetized rats
Release of gastrin from the skeletal muscles and from the antral mucosa in cats induced by sulfonuric drugs
Release of gastrointestinal peptides in response to vagal activation induced by electrical stimulation, feeding and suckling
Plasma levels of somatostatin following a test meal in dogs Initial atropine resistant vagally mediated decrease of somatostain levels and increase of gastrin and insulin levels
Decreased release of somatostatin into the portal vein following electrical vagal stimulation in the cat
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