Glutathione S-transferase M1 and T1 gene polymorphisms in patients with chronic plaque-type psoriasis: A case-control study

Objective: To determine the role of glutathione S-transferase (GST) isoenzyme polymorphisms as susceptibility factors in patients with psoriasis in a Turkish cohort. Subjects and Methods: In this case-control study, 105 patients with plaque-type psoriasis and 102 healthy controls were recruited from the dermatology outpatient clinics of two university hospitals. Genomic DNA was extracted from whole blood using a DZ DNA isolation kit. Multiplex PCR was used to determine GSTM1 and GSTT1 polymorphisms in the isolated DNAs. Results: Of the 150 patients with psoriasis, 83 (79%) were identified with the GSTT1 genotype and 22 (21%) with the null genotype. Of the 102 patients in the control group, 69 (67.6%) subjects were identified with the GSTT1 genotype and 33 (32.4%) with the null genotype. There was no significant difference between the patient and control groups (p = 0.063). Regarding the GSTM1 polymorphism, 54 (51.4%) patients were identified with this genotype and 51 (48.6%) with the null genotype; in the control group, 50 (49%) were identified with this genotype and 52 (51%) with the null genotype. Again there was no statistically significant difference between the groups (p = 0.957). Conclusion: In this Turkish cohort of patients with psoriasis, neither GSTT1 nor GSTM1 polymorphisms were associated with disease susceptibility. Larger studies with a wider range of GST isoenzyme are needed

Tanınız nedir 1? [2]

[No abstract available

What is your diagnosis?

WOS: 000390279100009

Nonvenereal sclerosing lymphangitis of the penis: Scientific letter [Penisin nonveneryal sklerozan lenfanjiti]

Nonvenereal sclerosing lymphangitis is a rarely seen disease characterized by traumatic obstruction of big lymphatic vessels of penis after a hard sexual intercourse. A 44-year-old male patient applied to our outpatient clinic for a rope-like thickening on his penis. His history revealed a trauma to the penis during sexual intercourse 1-2 days ago. There was no history of any drug use. A firm, skin-colored, cord-like lesion located perpendicular to the long axis of the penis and completely surrounding the dorsal coronary sulcus of the penis was detected on the dermatological examination. The complete blood count, blood chemistry, urinalysis values were normal; rapid plasma reagin, HIV, and hepatitis markers were negative. Penile Doppler ultrasonography was found to be normal. The patient was diagnosed as nonvenereal sclerosing lymphangitis by current clinical and laboratory findings. We think that it is quite important to diagnose this rarely seen disease especially by dermatologists and urologists to avoid misdiagnosis, unnecessary laboratary examinations and treatment. Copyright © 2012 by Türkiye Klinikleri

A Case of Acrodermatitis Chronica Atrophicans Causedby Borrelia burgdorferi Infection

Lyme hastalığı Borrelia burgdorferi'nin neden olduğu multisistemik bir zoonozdur. B. burgdorferi Spirochaetacea ailesinden gevşek kıvrımlı ve hareketli bir spiroket olup, İxodes cinsi sert kenelerin ısırması ile insanlara geçmektedir. Eritema migrans, akrodermatitis kronika atrofikans ve morfea benzeri lezyonlar, deri bulguları olarak karşımıza çıkabilmektedir. Geç dönem lezyonu olan ve sıklıkla kırk yaş üstü kadınlarda görülen akrodermatitis kronika atrofikans, kızarıklık ve şişlikle başlayıp aylar ya da yıllar içinde atrofi ve skleroza neden olabilmektedir. Bu raporda akrodermatitis kronika atrofikansa neden olan bir B. burgdorferi enfeksiyonunun sunulması amaçlanmıştır.Lyme disease is a multisystemic zoonosis caused by Borrelia burgdorferi. B. burgdorferi is a motile spirochete with loose spirals from Spirochaetaceae family and Lyme disease is acquired by humans through the bite of hard ticks of Ixodes species. Erythema migrans, acrodermatitis chronica atrophicans and morphea-like lesions present as skin lesions. Acrodermatitis chronica atrophicans that is the late lesion of Lyme disease and that is often seen in women over the age of forty presents as hyperemia and swelling and can lead to atrophy and sclerosis within months or years. In this study we report a case of acrodermatitis chronica atrophicans caused by B. burgdorferi infection

Acute generalized exanthematous pustulosis associated with terbinafine: a case report

WOS: 000323527300010PubMed: 23432048A 27-year-old male patient who has used oral terbinafine for two weeks was admitted to our outpatient clinic for non-follicular millimetric pustules on erythematous and edematous different-sized plaques on his trunk and flexural areas. He was diagnosed with acute generalized exanthematous pustulosis (AGEP) because of terbinafine use in the light of history, clinical and histopathological findings. An AGEP is a rare and severe pustular reaction usually triggered by systemic drug intake. Approximately, 2.3% of the patients having oral terbinafine have been reported to develop cutaneous adverse effects. Although terbinafine is a commonly used medicine, it must be considered that it may cause severe adverse reactions

Piebaldism: A familial case report [Piebaldizm: Ailesel bir olgu sunumu]

Piebaldism is a rare autosomal dominant skin disease presented with white forelock and depigmented patches. It is characterized by congenital absence of melanocytes and caused by mutation of KIT-proto-oncogene. KIT gene encodes transmembranous receptors on the surface of the melanocytes and it is responsible for the migration, proliferation, and differentation of the melanoblasts. The exact prevalence is unknown. It affects the both sexes equally. Here, we present a 3-year-old case admitted by depigmented macules, patches, and white forelock on forehead, trunk, upper and lower extremities. He had no accompanying systemic diseases and was diagnosed as piebaldism. His mother and older sister had similar lesions. On the occasion of this case, we aimed to create an awareness about piebaldism which may be confused especially with vitiligo clinically. Copyright © 2013 by Türkiye Klinikleri