Obstrucción de la vía biliar principal secundaria a mieloma de involucro pancreático

ResumenSe presenta el caso de una mujer de 69 años de edad con colangitis aguda, debido a la compresión extrínseca de las vías biliares por el desarrollo de mieloma. El involucro del páncreas secundario a mieloma múltiple es poco común. La paciente se manejó con radioterapia. La reducción del tamaño del tumor y sin recidiva de la colangitis se observaron después de 12 meses.AbstractThe case is presented on a 69 year-old female with acute cholangitis due to extrinsic bile duct compression caused by pancreatic myeloma involvement. Pancreas involvement with multiple myeloma is uncommon. The patient was managed with localised radiotherapy. There was a reduction in tumour size and no recurrence of cholangitis observed after 12 months of follow-up

Clinical and Immunopathologic Profile of Mexican Patients with IgG4 Autoimmune Pancreatitis

Autoimmune pancreatitis is part of the spectrum of IgG4-associated diseases. Its diagnostic criteria and histological subtypes have been formally proposed recently and although based on current data it has been suggested that there are differences in clinical presentation among populations, more research is needed to properly establish if this heterogeneity exists. In this paper, we describe 15 cases of autoimmune pancreatitis diagnosed at a Mexican centre of reference, all of them associated to the lymphoplasmocytic sclerosing pancreatitis variant. The mean age at the onset of symptoms was 47.5 ± 14.4 years, and 53% of patients were male. The main manifestations were weight loss (87%), obstructive jaundice (53%), and acute (27%) and chronic (27%) pancreatitis. Only 20% of patients had high IgG4 serum levels at the time of diagnosis. All patients receiving prednisone responded favourably, both in their pancreatic and extrapancreatic manifestations. Clinical manifestations of Mexican patients showed certain differences with respect to those usually reported

Occult Follicular Thyroid Carcinoma presenting as Primary Breast Tumor with Sternal and Skull Metastasis

Introduction: Follicular thyroid carcinoma (FTC) that initially presented as breast tumor with no previous medical history of malignancy of thyroid gland is relatively rare and may cause diagnostic confusion.Presentation of case: We report a 59-year-old Mexican woman with no prior history of malignant thyroid neoplasm that presents with pain and swelling in the upper outer quadrant of the left breast with a year of evolution. Subsequently, subcutaneous tumor was identified in left parietal region. Clinically it was thought in primary breast tumor metastasis to skull. Furthermore, computerized tomography scan identified a tumor in the deep portion of the left breast, infiltrating the sternum that subsequently was confirmed a follicular carcinoma of the thyroid gland.Conclusion: Metastatic FTC may mimic a primary breast tumor. The combined use of clinical information, histopathology and immunohistochemistry were important to establishing a correct cancer diagnosis

Impact of shelf temperature on freeze-drying process and porosity development

[EN] The freeze-drying kinetics and the superficial porosity development of grapefruit puree. The impact of biopolymers addition (gum Arabic and bamboo fiber) and to apply (40 ºC) or not shelf temperature (room temperature) was considered. To increase the shelves temperature during freeze-drying allowed to an important drying time reduction and doesn’t supposed a lower porosity related to the collapse development of the structure. Biopolymers do not affect the drying kinetics. From this results, biopolymers addition and to heat at least up to 40 ºC during grapefruit freeze-drying should be recommended.The authors thank the Ministerio de Economía y Competitividad and the Ministerio de Economía, Industria y Competitividad for the financial support given through the Projects AGL 2012-39103 and AGL 2017-89251-R (AEI/FEDER-UE), respectively. Egas-Astudillo, L.A thanks the Secretary of Higher Education, Science, Technology and Innovation (SENECYT) of the Republic of Ecuador for the contribution to this research.Egas Astudillo, LA.; Silva Espinoza, MA.; Uscanga Ramos, MA.; Martínez Navarrete, N.; Camacho Vidal, MM. (2018). Impact of shelf temperature on freeze-drying process and porosity development. En IDS 2018. 21st International Drying Symposium Proceedings. Editorial Universitat Politècnica de València. 843-850. https://doi.org/10.4995/IDS2018.2018.7481OCS84385

Envío dirigido de drogas y genes en biomedicina

Los sistemas de envío dirigido de drogas y genes se definen como los mecanismos para introducir agentes terapéuticos en el cuerpo; en los últimos años se ha puesto mucha atención en el diseño de estos sistemas, con la finalidad de poder controlar dosis, que la entrega sea específica y, además, dirigida en el sitio deseado sin afectar o dañar órganos y tejidos sanos. Para ello se han propuesto y analizado minuciosamente varios métodos, algunos de éstos son: partículas virales, liposomas, nanoacarreadores poliméricos y nanopartículas magnéticas

LABORATORIO REMOTO PARA SISTEMAS DE CONTROL DISCRETOS MEDIANTE INTERNET DE LAS COSAS (REMOTE LABORATORY FOR DISCRETE CONTROL SYSTEMS THROUGH INTERNET OF THINGS)

Resumen En este trabajo se presenta el desarrollado de un laboratorio remoto de sistemas de control discreto empleando la técnica de Hardware in the Loop (HIL). El laboratorio consta de dos partes principales, la primera es una plataforma HIL integrada por tres elementos, los cuales son un emulador en tiempo real, un controlador PID discreto y una tarjeta de adquisición de datos. El emulador se embebió sobre una tarjeta de desarrollo NI myRIO-1900 empleando el lenguaje de programación grafico de la compañía National Instruments LabVIEW. La principal función del emulador es reproducir el comportamiento de sistemas de primer y segundo orden que representan el proceso en un sistema de control. La plataforma cuenta con una biblioteca de los siguientes procesos preestablecidos: primer orden general, segundo orden general, mecánico de traslación y rotación de masa-resorte-amortiguador, circuito eléctrico RC y RLC, tanque de agitación continua y de motor CD; esta plataforma permite a los usuarios seleccionar y configurar los parámetros de cada uno de los procesos. El controlador PID también es configurable, en este elemento el usuario puede seleccionar el periodo de ejecución y las ganancias proporcional, integral y derivativa de una estructura PID en paralelo. La tarjeta de adquisición de datos empleada fue una NI myDAQ, la cual trabaja sobre la misma plataforma de programación de LabVIEW, esta tarjeta permite monitorear las variables del proceso, recolectando y almacenando los datos que describen la respuesta del sistema de control con una resolución y durante un tiempo definidos por el usuario. La segunda parte del laboratorio remoto es una aplicación web implementada en Android Studio, la cual esta vinculada al igual que LabVIEW a una base de datos en tiempo real desarrollada mediante el software Firebase, esta permite enviar y recibir información entre ambos sistemas. El usuario de esta aplicación tiene acceso mediante su dispositivo móvil con conexión a internet. La aplicación contiene una interfaz que guía al usuario en la configuración de la planta, el controlador y la tarjeta de adquisición de datos. Palabras clave: Emulador, Hardware in the Loop, Laboratorio Remoto, Controlador PID, Sistemas de Control. Abstract This paper presents the development of a remote laboratory for discrete control systems using the Hardware in the Loop (HIL) technique. The laboratory consists of two main parts, the first is a HIL platform made up of three elements, which are a real-time emulator, a discrete PID controller and a data acquisition board. The emulator was embedded on a NI myRIO-1900 development board using the National Instruments LabVIEW graphical programming language. The main function of the emulator is to reproduce the behavior of first and second order systems that represent the process in a control system. The platform has a library of the following pre-established processes: first general order, second general order, mechanical translation and rotation of mass-spring-damper, RC and RLC electrical circuit, continuous stirring tank and DC motor; This platform allows users to select and configure the parameters of each of the processes. The PID controller is also configurable, in this element the user can select the execution period and the proportional, integral and derivative gains of a PID structure in parallel. The data acquisition board used was a NI myDAQ, which works on the same LabVIEW programming platform, this card allows monitoring the process variables, collecting and storing the data that describes the response of the control system with a resolution and for a user-defined time. The second part of the remote laboratory is a web application implemented in Android Studio, which, like LabVIEW, is linked to a real-time database developed using the Firebase software, which allows information to be sent and received between both systems. The user of this application has access through their mobile device with an internet connection. The application contains an interface that guides the user in the configuration of the plant, the controller and the data acquisition board. Keywords: Emulator, Hardware in the Loop, Remote Laboratory, PID Controller, Control Systems