17 research outputs found
Intermittent preventive treatment for malaria in pregnancy in Africa: What's new, what's needed?
Falciparum malaria is an important cause of maternal, perinatal and neonatal morbidity in high transmission settings in Sub-Saharan Africa. Intermittent preventive treatment with sulphadoxine-pyrimethamine (SP-IPT) has proven efficacious in reducing the burden of pregnancy-associated malaria but increasing levels of parasite resistance mean that the benefits of national SP-IPT programmes may soon be seriously undermined in much of the region. Hence, there is an urgent need to develop alternative drug regimens for IPT in pregnancy. This paper reviews published safety and efficacy data on various antimalarials and proposes several candidate combination regimens for assessment in phase II/III clinical trials
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Component and system tests of the SLD Cerenkov Ring Imaging Detector
The components of the SLD barrel Cerenkov Ring Imaging Detector (CRID) are now built and are being installed. We report on tests of these, including tests of the fiber optic calibration system, detailed studies of electron drift paths on production drift boxes and detectors, tests of the dynamic gating system and its effect on drift path distortions due to space-charge, and a measurement of the electron lifetime in a production drift box. In addition, we report on the UV transmission of recirculated liquid C{sub 6}F{sub 14} and on the effects of CRID construction materials on electron lifetime. 9 refs., 11 figs
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Cherenkov Ring Imaging Detector front-end electronics
The SLD Cherenkov Ring Imaging Detector use a proportional wire detector for which a single channel hybrid has been developed. It consists of a preamplifier, gain selectable amplifier, load driver amplifier, power switching, and precision calibrator. For this hybrid, a bipolar, semicustom integrated circuit has been designed which includes video operational amplifiers for two of the gain stages. This approach allows maximization of the detector volume, allows DC coupling, and enables gain selection. System tests show good noise performance, calibration precision, system linearity, and signal shape uniformity over the full dynamic range. 10 refs., 8 figs
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Component and system tests of the SLD Cerenkov Ring Imaging Detector
The components of the SLD barrel Cerenkov Ring Imaging Detector (CRID) are now built and are being installed. We report on tests of these components, including tests of the fiber optic calibration system, detailed studies of electron drift paths on production drift boxes and detectors, tests of the dynamic gating systems and its effect on drift path distortions due to space-charge, and a measurement of the electron lifetime in a production drift box. In addition, we report on the UV transmission of recirculated liquid freon and on the effects of CRID construction materials on electron lifetime. 16 refs., 12 figs