Separated children seeking asylum in Ireland.

This report updates the first report of the Irish Refugee Council published in 1999, entitled Separated children seeking asylum in Ireland: A report on legal and social conditions. At the time of the publication of that report, there were 32 separated children seeking asylum in Ireland. The number of separated children seeking asylum in Ireland has increased markedly. By March 2003, the number of separated children, entering Ireland and referred to the North Eastern Area Health Board was 2,7172. Nearly half, or 1,113 children, were reunited with family members already in Ireland. 1,316 separated children, under the care of the Health Boards, have made applications for asylum under the 1951 Geneva Convention on the Status of Refugees. Neither the Government nor non-statutory agencies anticipated this increase in the numbers of separated minors arriving in Ireland. Therefore administrative procedures and care services have had to be responsive to emergent needs rather than having developed through advance planning. This report aims to examine policy and practice with respect to the legal and social conditions of separated children in Ireland, in light of the Separated Children in Europe Programme’s (SCEP)3 ‘Statement of Good Practice’ (SGP). The Irish Refugee Council, a member of the Separated Children in Europe Programme, commissioned the report

FISH characterization of the R-banded rabbit (Oryctolagus cuniculus) karyotype

"Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access "International audienc

Cytogenetic and physical mapping of the rabbit MHC using a BAC library

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A physical map of large segments of pig chromosome 7q11-q14: comparative analysis with human chromosome 6p21.

Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-AccessInternational audienc

Characterization of Dendritic Cells Subpopulations in Skin and Afferent Lymph in the Swine Model

Transcutaneous delivery of vaccines to specific skin dendritic cells (DC) subsets is foreseen as a promising strategy to induce strong and specific types of immune responses such as tolerance, cytotoxicity or humoral immunity. Because of striking histological similarities between human and pig skin, pig is recognized as the most suitable model to study the cutaneous delivery of medicine. Therefore improving the knowledge on swine skin DC subsets would be highly valuable to the skin vaccine field. In this study, we showed that pig skin DC comprise the classical epidermal langerhans cells (LC) and dermal DC (DDC) that could be divided in 3 subsets according to their phenotypes: (1) the CD163 neg /CD172a neg, (2) the CD163 high CD172a pos and (3) the CD163 low CD172a pos DDC. These subtypes have the capacity to migrate from skin to lymph node since we detected them in pseudo-afferent lymph. Extensive phenotyping with a set of markers suggested that the CD163 high DDC resemble the antibody response-inducing human skin DC/macrophages whereas the CD163 neg CD172 low DDC share properties with the CD8 + T cell response-inducing murine skin CD103 pos DC. This work, by showing similarities between human, mouse and swine skin DC, establishes pig as a model of choice for the development of transcutaneous immunisation strategies targeting DC

Functional approaches to study pig MHC genes

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Construction of a physical map within the extended SLA region on the long arm of chromosome 7

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133 new gene localizations on the rabbit cytogenetic map

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Expanded comparative mapping between man and rabbit and detection of a new conserved segment between HSA22 and OCU4

International audienceRabbit, a domestic species exploited both in animal production and medical research has only recently begun to be included in gene mapping projects, in particular by the French National Institute of Agronomics. By 2002, less than 60 genes had been precisely localised on rabbit chromosomes, which led us to start a large-scale project on gene mapping in rabbit with the publication of 133 gene localisations in 2003 (Chantry-Darmon et al., 2003). Here, we report the localisation of 102 new genes resulting in good coverage of the rabbit genome and an eight-fold enrichment of the gene map. In addition, we have detected a new conserved segment between rabbit chromosome 4q15.3 and part of human chromosome 22 and thus improved the comparative map with the human genome

Progress in the rabbit cytogenetic map

"Chantier qualité spécifique "Auteurs Externes" département de Génétique animale : uniquement liaison auteur au référentiel HR-Access "International audienc