Two-fluid model for a rotating trapped Fermi gas in the BCS phase

We investigate the dynamical properties of a superfluid gas of trapped fermionic atoms in the BCS phase. As a simple example we consider the reaction of the gas to a slow rotation of the trap. It is shown that the currents generated by the rotation can be understood within a two-fluid model similar to the one used in the theory of superconductors, but with a position dependent ratio of normal and superfluid densities. The rather general result of this paper is that already at very low temperatures, far below the critical one, an important normal-fluid component appears in the outer regions of the gas. This renders the experimental observation of superfluidity effects more difficult and indicates that reliable theoretical predictions concerning other dynamical properties, like the frequencies of collective modes, can only be made by taking into account temperature effects.Comment: 6 pages, 4 figure

Dynamics of a trapped Fermi gas in the BCS phase

We derive semiclassical transport equations for a trapped atomic Fermi gas in the BCS phase at temperatures between zero and the superfluid transition temperature. These equations interpolate between the two well-known limiting cases of superfluid hydrodynamics at zero temperature and the Vlasov equation at the critical one. The linearized version of these equations, valid for small deviations from equilibrium, is worked out and applied to two simple examples where analytical solutions can be found: a sound wave in a uniform medium and the quadrupole excitation in a spherical harmonic trap. In spite of some simplifying approximations, the main qualitative results of quantum mechanical calculations are reproduced, which are the different frequencies of the quadrupole mode at zero and the critical temperature and strong Landau damping at intermediate temperatures. In addition we suggest a numerical method for solving the semiclassical equations without further approximations.Comment: 15 pages, 4 figures; v2: discussion and references adde

Exploring the Impact of and Perceptions about Interactive, Self-Explaining Environments in Molecular-Level Animations

This mixed-method study investigates the effects of interactivity in animations of a molecular-level process and explores perceptions about the animated learning tool used. Treatments were based on principles of cognitive psychology designed to study the main effects of treatment and spatial ability and their interaction. Results with students (n = 189) showed that science majors scored higher than non-science majors in retention measures (i.e., structure and function) but not in transfer. Significant main effects were found for treatment in function questions and spatial ability in structure questions. There was a significant interaction between treatment and spatial ability in structure questions. Additionally, in this study participants believed the key and the motion of ions and molecules were the most helpful parts of the animation. This study shows that students perceive the animations as being supportive of their learning, suggesting that animations do have a role in science classrooms

Heat shock response and insulin-associated neurodegeneration

Dysfunctional insulin and insulin-like growth factor-I (IGF-I) signaling contributes to the pathological progression of diabetes, diabetic peripheral neuropathy (DPN), Alzheimer's (AD), Parkinson's (PD) and Huntington's diseases (HD). Despite their prevalence, there are limited therapeutic options available for the treatment of these neurodegenerative disorders. Therefore, establishing a link between insulin/IGF-I and the pathoetiology of these diseases may provide alternative approaches toward their management. Many of the heat shock proteins (Hsps) are well-known molecular chaperones that solubilize and clear damaged proteins and protein aggregates. Recent studies suggest that modulating Hsps may represent a promising therapeutic avenue for improving insulin and IGF-I signaling. Pharmacological induction of the heat shock response (HSR) may intersect with insulin/IGF-I signaling to improve aspects of neurodegenerative phenotypes. Herein, we review the intersection between Hsps and the insulin/IGF systems under normal and pathological conditions. The discussion will emphasize the potential of non-toxic HSR inducers as viable therapeutic agents

Response Regarding Bureau Financial Education Programs (Docket No. CFPB-2018-0015)

Response discussing whether the Consumer Federal Protection Bureau should continue its financial education programs

Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy

Quantification of intra-epidermal nerve fibers (iENFs) is an important approach to stage diabetic peripheral neuropathy (DPN) and is a promising clinical endpoint for identifying beneficial therapeutics. Mechanistically, diabetes decreases neuronal mitochondrial function and enhancing mitochondrial respiratory capacity may aid neuronal recovery from glucotoxic insults. We have proposed that modulating the activity and expression of heat shock proteins (Hsp) may be of benefit in treating DPN. KU-32 is a C-terminal Hsp90 inhibitor that improved thermal hypoalgesia in diabetic C57Bl/6 mice but it was not determined if this was associated with an increase in iENF density and mitochondrial function. After 16 weeks of diabetes, Swiss Webster mice showed decreased electrophysiological and psychosensory responses and a >30% loss of iENFs. Treatment of the mice with ten weekly doses of 20 mg/kg KU-32 significantly reversed pre-existing deficits in nerve conduction velocity and responses to mechanical and thermal stimuli. KU-32 therapy significantly reversed the pre-existing loss of iENFs despite the identification of a sub-group of drug-treated diabetic mice that showed improved thermal sensitivity but no increase in iENF density. To determine if the improved clinical indices correlated with enhanced mitochondrial activity, sensory neurons were isolated and mitochondrial bioenergetics assessed ex vivo using extracellular flux technology. Diabetes decreased maximal respiratory capacity in sensory neurons and this deficit was improved following KU-32 treatment. In conclusion, KU-32 improved physiological and morphologic markers of degenerative neuropathy and drug efficacy may be related to enhanced mitochondrial bioenergetics in sensory neurons

Validation of equilibrium tools on the COMPASS tokamak

SOFT 2014 conference, submitted to Fusion Engineering and DesignInternational audienceVarious MHD (magnetohydrodynamic) equilibrium tools, some of which being recently developed or considerably updated, are used on the COMPASS tokamak at IPP Prague. MHD equilibrium is a fundamental property of the tokamak plasma, whose knowledge is required for many diagnostics and modelling tools. Proper benchmarking and validation of equilibrium tools is thus key for interpreting and planning tokamak experiments. We present here benchmarks and comparisons to experimental data of the EFIT++ reconstruction code [L.C. Appel et al., EPS 2006, P2.184], the free-boundary equilibrium code FREEBIE [J.-F. Artaud, S.H. Kim, EPS 2012, P4.023], and a rapid plasma boundary reconstruction code VacTH [B. Faugeras et al., PPCF 56, 114010 (2014)]. We demonstrate that FREEBIE can calculate the equilibrium and corresponding poloidal field (PF) coils currents consistently with EFIT++ reconstructions from experimental data. Both EFIT++ and VacTH can reconstruct equilibria generated by FREEBIE from synthetic, optionally noisy diagnostic data. Hence, VacTH is suitable for real-time control. Optimum reconstruction parameters are estimated

An Improved Implementation and Abstract Interface for Hybrid

Hybrid is a formal theory implemented in Isabelle/HOL that provides an interface for representing and reasoning about object languages using higher-order abstract syntax (HOAS). This interface is built around an HOAS variable-binding operator that is constructed definitionally from a de Bruijn index representation. In this paper we make a variety of improvements to Hybrid, culminating in an abstract interface that on one hand makes Hybrid a more mathematically satisfactory theory, and on the other hand has important practical benefits. We start with a modification of Hybrid's type of terms that better hides its implementation in terms of de Bruijn indices, by excluding at the type level terms with dangling indices. We present an improved set of definitions, and a series of new lemmas that provide a complete characterization of Hybrid's primitives in terms of properties stated at the HOAS level. Benefits of this new package include a new proof of adequacy and improvements to reasoning about object logics. Such proofs are carried out at the higher level with no involvement of the lower level de Bruijn syntax.Comment: In Proceedings LFMTP 2011, arXiv:1110.668

Freshwater monitoring by nanopore sequencing.

While traditional microbiological freshwater tests focus on the detection of specific bacterial indicator species, including pathogens, direct tracing of all aquatic DNA through metagenomics poses a profound alternative. Yet, in situ metagenomic water surveys face substantial challenges in cost and logistics. Here, we present a simple, fast, cost-effective and remotely accessible freshwater diagnostics workflow centred around the portable nanopore sequencing technology. Using defined compositions and spatiotemporal microbiota from surface water of an example river in Cambridge (UK), we provide optimised experimental and bioinformatics guidelines, including a benchmark with twelve taxonomic classification tools for nanopore sequences. We find that nanopore metagenomics can depict the hydrological core microbiome and fine temporal gradients in line with complementary physicochemical measurements. In a public health context, these data feature relevant sewage signals and pathogen maps at species level resolution. We anticipate that this framework will gather momentum for new environmental monitoring initiatives using portable devices