248 research outputs found

    Letter from L. B. Upshaw

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    Letter concerning a copy of the catalogue for Utah Agricultural College

    Adolescents\u27 Perceptions of their Relationship with Family Members

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    This exploratory quantitative study examined adolescents\u27 perceptions of their relationship, in terms of interpersonal boundaries, with family members. The literature review revealed different types of boundaries and boundary positions. The Family Adaptability and Cohesion Scale was the instrument utilized for assessing the adaptability. (EACES II) The questions this study answers include how the adolescents\u27 boundary position, in terms of cohesion, and boundary adaptability effects delinquency and school achievement? Also, how do religious activities of the adolescents effect delinquency and school achievement? Self-survey questionnaires and FACES II inventories were administered at two separate high schools. The findings revealed connected family cohesion and frequent religious activities are correlated with high grades at school and adolescents are less likely to be involved in the juvenile justice system. Implications for social work practice and policy are discussed

    EVALUATION OF FEASIBILITY OF FRUIT AND VEGETABLE CROPS USING MARKET WINDOW ANALYSIS

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    Fruits and vegetables have been identified as potential production alternatives to use available farm resources. Several "market window" studies have been undertaken to evaluate such feasibility. These state and regional studies are analyzed and compared to identify underlying assumptions and methodologies. Recommendations of the studies are evaluated on an aggregate basis and limitations of the market window technique are identified and discussed. The technique was judged to be useful in planning because it involves consideration of potential costs to be incurred, markets to be evaluated, and price expectations for the various commodities considered.Crop Production/Industries,

    Cultural Humility in Action: Reflective and Process-Oriented Supervision With Black Trainees

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    The supervisory relationship is considered a core experience in the field of psychology. The primary goal of this experience is to support trainees’ development of strong clinical skills, as well as expertise, to ensure adequate treatment of patients and promote learning and professional growth. However, it has become evident that supervisors continue to struggle with adapting an integrated and contextual approach to diversity. This becomes problematic when working with trainees of Color who are often navigating multiple identities in professional spaces and are at risk for burnout and unintended harm from individuals in a supervisory role. Further, the expanding sociopolitical landscape and diversification of professional spheres provide evidence for the need for contextually and culturally humble approaches to supervision, particularly when working with trainees of Color. This piece provides 2 illustrative examples of supervisory experiences of Black trainees during a time of heightened racial tensions in the United States. We seek to use these critical incidents to highlight the impact of both a culturally unresponsive approach that evidenced unacknowledged cultural blind spots, as well as a culturally responsive and humble approach to supervision. Recommendations for the work of supervision with trainees of Color, particularly Black trainees, are provided. For improvement, we recommend continuing education, implementing a process-oriented model of supervision, engaging in open dialogue, facilitating opportunities for mentorship, creating safe spaces, and carefully considering the larger sociopolitical context

    Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G

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    Background: The activating immunoreceptor NKG2D is expressed on Natural Killer (NK) cells and subsets of T cells. NKG2D contributes to anti-tumour and anti-viral immune responses in vitro and in vivo. The ligands for NKG2D in humans are diverse proteins of the MIC and ULBP/RAET families that are upregulated on the surface of virally infected cells and tumours. Two splicing variants of ULBP5/RAET1G have been cloned previously, but not extensively characterised. Methodology/Principal Findings: We pursue a number of approaches to characterise the expression, trafficking, and function of the two isoforms of ULBP5/RAET1G. We show that both transcripts are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers. The full-length transcript, RAET1G1, is predicted to encode a molecule with transmembrane and cytoplasmic domains that are unique amongst NKG2D ligands. Using specific anti-RAET1G1 antiserum to stain tissue microarrays we show that RAET1G1 expression is highly restricted in normal tissues. RAET1G1 was expressed at a low level in normal gastrointestinal epithelial cells in a similar pattern to MICA. Both RAET1G1 and MICA showed increased expression in the gut of patients with celiac disease. In contrast to healthy tissues the RAET1G1 antiserum stained a wide variety or different primary tumour sections. Both endogenously expressed and transfected RAET1G1 was mainly found inside the cell, with a minority of the protein reaching the cell surface. Conversely the truncated splicing variant of RAET1G2 was shown to encode a soluble molecule that could be secreted from cells. Secreted RAET1G2 was shown to downregulate NKG2D receptor expression on NK cells and hence may represent a novel tumour immune evasion strategy. Conclusions/Significance: We demonstrate that the expression patterns of ULBP5RAET1G are very similar to the well-characterised NKG2D ligand, MICA. However the two isoforms of ULBP5/RAET1G have very different cellular localisations that are likely to reflect unique functionality

    Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection

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    The activating natural killer (NK) cell receptor Ly49H recognizes the mouse cytomegalovirus (MCMV) m157 glycoprotein expressed on the surface of infected cells and is required for protection against MCMV. Although Ly49H has previously been shown to signal via DAP12, we now show that Ly49H must also associate with and signal via DAP10 for optimal function. In the absence of DAP12, DAP10 enables Ly49H-mediated killing of m157-bearing target cells, proliferation in response to MCMV infection, and partial protection against MCMV. DAP10-deficient Ly49H+ NK cells, expressing only Ly49H–DAP12 receptor complexes, are partially impaired in their ability to proliferate during MCMV infection, display diminished ERK1/2 activation, produce less IFN-γ upon Ly49H engagement, and demonstrate reduced control of MCMV infection. Deletion of both DAP10 and DAP12 completely abrogates Ly49H surface expression and control of MCMV infection. Thus, optimal NK cell–mediated immunity to MCMV depends on Ly49H signaling through both DAP10 and DAP12

    Response vs. Perception

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    Three experiments were conducted in which college students read, and then attempted to match, a series of written descriptive passages with the referent photographs on which they were based; the photographs sho wed the face of an actor, representing a variety of emotional expressions. In Experiment I, subjects provided with a series of context passages depicting a narrow range of emotions (neither pleasant nor unpleasant) chose “matches” having more extreme pleasantness values than did subjects provided with context passages depicting a wide range of descriptions on the pleasantness dimension when responding to test descriptions embedded within the context series. In Experiments II and III, contrast effects were obtained; subjects who had read mostly unpleasant context passages chose more pleasant referents in response to neutral test descriptions than did those who had read mostly pleasant descriptions. The results of all three experiments suggested that these effects were mediated in large part by a response bias, the tendency to use each response alternative with roughly equal frequency. In Experiments II and III, there was suggestive evidence for the possibility that a more central (or perceptual) mechanism may also have contributed to the observed results.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45367/1/11031_2004_Article_BF00992590.pd
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