Defining Kawasaki disease and pediatric inflammatory multisystem syndrome-temporally associated to SARS-CoV-2 infection during SARS-CoV-2 epidemic in Italy: results from a national, multicenter survey

Background: There is mounting evidence on the existence of a Pediatric Inflammatory Multisystem Syndrome-temporally associated to SARS-CoV-2 infection (PIMS-TS), sharing similarities with Kawasaki Disease (KD). The main outcome of the study were to better characterize the clinical features and the treatment response of PIMS-TS and to explore its relationship with KD determining whether KD and PIMS are two distinct entities. Methods: The Rheumatology Study Group of the Italian Pediatric Society launched a survey to enroll patients diagnosed with KD (Kawasaki Disease Group - KDG) or KD-like (Kawacovid Group - KCG) disease between February 1st 2020, and May 31st 2020. Demographic, clinical, laboratory data, treatment information, and patients' outcome were collected in an online anonymized database (RedCAP®). Relationship between clinical presentation and SARS-CoV-2 infection was also taken into account. Moreover, clinical characteristics of KDG during SARS-CoV-2 epidemic (KDG-CoV2) were compared to Kawasaki Disease patients (KDG-Historical) seen in three different Italian tertiary pediatric hospitals (Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste; AOU Meyer, Florence; IRCCS Istituto Giannina Gaslini, Genoa) from January 1st 2000 to December 31st 2019. Chi square test or exact Fisher test and non-parametric Wilcoxon Mann-Whitney test were used to study differences between two groups. Results: One-hundred-forty-nine cases were enrolled, (96 KDG and 53 KCG). KCG children were significantly older and presented more frequently from gastrointestinal and respiratory involvement. Cardiac involvement was more common in KCG, with 60,4% of patients with myocarditis. 37,8% of patients among KCG presented hypotension/non-cardiogenic shock. Coronary artery abnormalities (CAA) were more common in the KDG. The risk of ICU admission were higher in KCG. Lymphopenia, higher CRP levels, elevated ferritin and troponin-T characterized KCG. KDG received more frequently immunoglobulins (IVIG) and acetylsalicylic acid (ASA) (81,3% vs 66%; p = 0.04 and 71,9% vs 43,4%; p = 0.001 respectively) as KCG more often received glucocorticoids (56,6% vs 14,6%; p < 0.0001). SARS-CoV-2 assay more often resulted positive in KCG than in KDG (75,5% vs 20%; p < 0.0001). Short-term follow data showed minor complications. Comparing KDG with a KD-Historical Italian cohort (598 patients), no statistical difference was found in terms of clinical manifestations and laboratory data. Conclusion: Our study suggests that SARS-CoV-2 infection might determine two distinct inflammatory diseases in children: KD and PIMS-TS. Older age at onset and clinical peculiarities like the occurrence of myocarditis characterize this multi-inflammatory syndrome. Our patients had an optimal response to treatments and a good outcome, with few complications and no deaths

Cardiopoietic cell therapy for advanced ischemic heart failure: results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort

Voting, fast and slow

This package contains data to replicate and extend a study on the 2012 Parlamentarie, the Five Star Movement primary elections used to identify prospective candidate MPs for the 2013 general elections. We investigate the effect of position on screen on the candidate rank in each electoral district and collected likability ratings for a sample of districts. We provide the dataset about the election, the dataset with the likability ratings (stripped of personal information about raters), the candidates' self-uploaded pictures (as a .zip file, after excluding those portraying multiple people, children, or sensitive information) and the R scripts to replicate the analysis. The experimental design and data management plan were approved by the Research Ethics and Data Management Committee (REDC) of the Tilburg School of Humanities and Digital Sciences (TSHD) of Tilburg University, code REDC2020.201

Data underlying the publication: Time-resolved optical emission spectroscopy in CO2 nanosecond pulsed discharges

Data underlying graphs published in PSST: https://doi.org/10.1088/1361-6595/ac2411, detailing optical emission spectroscopy in a nanosecond repetitvely pulsed discharge in atmospheric pressure CO2. It details the complex temporal structure of the spectally resolved emission, which provides insight into gas temperature and electron density. The dataset contains 4 folders which contain the data on: I-V characteristics of the used NPG discharge Optical emmission spectra at different delays in the discharge, along with time evolution of specific C(-ionic) lines Time-resolved line profiles for specific O and C lines, for Stark width fitting, as well as associated fit parameter output and calculated electron densities. Spectra of N2 second positive system, CN violet system and C2 Swan bands, along with time-resolved temperature profiles both for in-pulse and afterglow, obtained from the N2 SPS. Readme files next to the data provide information the format of the data and what data is contained in the files, with respect to the publication.</p

Data underlying the publication: Time-resolved optical emission spectroscopy in CO2 nanosecond pulsed discharges

Data underlying graphs published in PSST: https://doi.org/10.1088/1361-6595/ac2411, detailing optical emission spectroscopy in a nanosecond repetitvely pulsed discharge in atmospheric pressure CO2. It details the complex temporal structure of the spectally resolved emission, which provides insight into gas temperature and electron density. The dataset contains 4 folders which contain the data on: I-V characteristics of the used NPG discharge Optical emmission spectra at different delays in the discharge, along with time evolution of specific C(-ionic) lines Time-resolved line profiles for specific O and C lines, for Stark width fitting, as well as associated fit parameter output and calculated electron densities. Spectra of N2 second positive system, CN violet system and C2 Swan bands, along with time-resolved temperature profiles both for in-pulse and afterglow, obtained from the N2 SPS. Readme files next to the data provide information the format of the data and what data is contained in the files, with respect to the publication.</p

A Survey of European Cybersecurity in Higher Education Programs

This sheet contains the answers from our european Cyber Security MSc Education Survey. The data shows which knowledge units various educations in Europe cover and to which extend. We drew conclusions in the paper "Are We Preparing Students to Build Security In? A Survey of European Cybersecurity in Higher Education Programs". The present dataset is newer and therefore extends the one we based our paper on