The Post-secular Debate: Introductory Remarks

This is an Accepted Manuscript of an article published by Taylor & Francis in European Legacy on 03/02/2015, available online: http://wwww.tandfonline.com/10.1080/10848770.2015.100692

Investigation of NLO properties of azo-azulene derivatives for nonlinear optical applications

Date du colloque&nbsp;: 09/2008</p

The importance of the principles of good laboratory practice in quality assurance of preclinical studies

Scientific Center of Drug Research, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaBackground: The institution, which studies the safety of chemicals, biotechnological substances and nanotechnology products, should conduct researches in accordance with the principles and rules of GLP (Good Laboratory Practice). This standard establishes principles of good laboratory practice for application in non-clinical studies of substances contained in the medicines, pesticides, cosmetic products, veterinary drugs, food and feed additives, and industrial chemicals. GLP rules is a concept of research management, including the organization, preparation and conduct of the study, activity monitoring, obtaining and documenting data, concluding the report. Compliance with GLP principles in the conduct of studies is a mandatory requirement imposed by national regulatory agencies to determine the safety of chemical compounds and other substances related to the protection of human health and the environment. The issue of quality assurance of drug substances is particularly relevant during the authorization process of drugs. Application of standards is an important issue not only in the production of drug substances, but also in preclinical research and clinical studies. Application of GLP rules in research institution is guaranteed by a center quality assurance program, as well as by the institution’s management control and independent audit. Conclusions: GLP implementation in biomedical research centers of the university in the country will lead to proper management of preclinical laboratories and therefore will increase the credibility of scientific results at international level

Some aspects of biomedical preclinical research involving laboratory animal

Scientific Center of Drug Research, Nicolae Testemitsanu State University of Medicine and Pharmacy Chisinau, the Republic of MoldovaBackground: Animal research has enormous utility as understanding the complex interactions of molecular mechanisms, biochemical and physiological study ultimately depends on intact organisms in vivo. The use of animals for biomedical research was the subject of much debate and continues to be today. The main question of this debate is whether or not correct, morally speaking, to conduct animal research. Scientists who use animals for these purposes mean that experiments should be done as humanely as possible. They agree that animals should not be used as long as there are testing methods producing similar results. Internationally these principles are reflected in the rules developed by the Organization for Economic Cooperation and Development for Good Laboratory Practice. However, the implementation of this legislation in our country aims at purchasing proper equipment of scientific laboratories for preclinical research, monitoring biomedical ethics and ensures quality results. The experimental ethics is a prerequisite for ensuring good scientific practice. Conclusion: The existence of a regulatory body to provide advice and evaluation of experimental design becomes mandatory enforcement of the concept of ethics in laboratory animal experiments

EVOLUTION OF MILK CATALASE ACTIVITY IN PRESENCE OF INHIBITOR AND ACTIVATOR SUBSTANCES

Milk catalase activity were carried out to determine the effect of different activators and inhibitors on enzyme activity. The experiments where conducted to estimate the catalase activity from fresh milk, fresh milk in addition with trichloroacetic acid, fresh milk in addition with tannin, fresh milk during the pasteurization process, fresh milk in addition with iron, fresh milk in addition with vitamins. Iron, vitamins, high temperature influence positive milk catalase activity; tannin, trichloroacetic acid and pasteurization temperature influence negative milk catalase activit

RESEARCHES REGARDING THE OBTAINING OF JUICE FROM SUGAR SORGHUM STALK

Sugar sorghum is a technical plant with high energy value due to the high productivity obtained per hectare. By pressing of sugar sorghum strains it can be obtained a juice that can be further used in various forms: alcohol, ethanol, etc

CONSIDERATIONS CONCERNING THE VALORIZATION OF THE JUICE OBTAINED FROM SUGAR SORGHUM STALK FROM ALCOHOL

 With a high production per hectare, sugar sorghum is a high value technical plant for farmers because from an average production of 70-80 t/ha, a high quantity of juice can be obtained, which can be used as such in the food industry (natural sweetener) or processed for the purpose of obtaining alcohol. The alcohol has a higher value/liter, can be stored more easily and its uses are multiple: in the food, pharmaceutical, chemical industry, etc

Characterization of Sucrose Thin Films for Biomedical Applications

Sucrose is a natural osmolyte accumulated in the cells of organisms as they adapt to environmental stress. In vitro sucrose increases protein stability and forces partially unfolded structures to refold. Thin films of sucrose (C12H22O11) were deposited on thin cut glass substrates by the thermal evaporation technique (P∼10−5 torr). Characteristics of thin films were put into evidence by Fourier Transform Infrared Spectroscopy (FTIR), X-ray Photoelectron Spectroscopy (XPS), scanning electron microscopy (SEM), and differential thermal analysis and thermal gravimetric analysis (TG/DTA). The experimental results confirm a uniform deposition of an adherent layer. In this paper we present a part of the characteristics of sucrose thin films deposited on glass in medium vacuum conditions, as a part of a culture medium for osteoblast cells. Osteoblast cells were used to determine proliferation, viability, and cytotoxicity interactions with sucrose powder and sucrose thin films. The osteoblast cells have been provided from the American Type Culture Collection (ATCC) Centre. The outcome of this study demonstrated the effectiveness of sucrose thin films as a possible nontoxic agent for biomedical applications

Методология и клинические аспекты опухолей молочной железы у несовершенолетних

Simpozion Naţional de Oncologie cu participare internaţională „Vigilenţa oncologică în activitatea medicală, depistarea precoce şi tratamentul tumorilor” dedicat aniversării de 40 ani de activitate a Catedrei de Oncologie, Hematologie şi Radioterapie a USMF “N. Testemiţanu”Summary: This article highlights the importance of clinical and methodological aspects of the mammary gland tumors of the girls, and it is based on the study conducted between 2013-2015 in the University Clinic and Pediatric Oncology Department of the INSP IO. The stake of this study was to argue the frequency of the fibroadenomas and phylloid tumors.Резюме: В данной статье рассматриваются клинические и методологические аспекты oпухоли молочной железы у девочек, и оно основано на исследовании, проведенной между 2013-2015 в университетской клинике в отделении детской онкологии INSP IO. Цель данного исследования было подтвердить частоту фиброаденомы и филоидных опухолях