HACIA LA COMPRENSION DE LA ESCUELA Y SUS VIVENCIAS Proyectos de Renovación Pedagógica para la Escuela Primaria

El presente estudio tiene la intención de brindarle un espacio al maestro para que se pronuncie sobre temas que conoce y, sobre todo, que sabe por su experiencia vivencial. A su vez, ha nacido de la convicción de que ya es tiempo de que el investigador vea en el saber docente (o del docente) una fuente viva, válida y llena de matices para profundizar en el conocimiento de la cotidianeidad de la escuela. Es preciso, de antemano, advertir una insuficiencia: la toma de la palabra por el maestro no puede venir de que alguien (llámese investigador, directivo, capacitador) le diga que hable; la verdadera voz del maestro será dicha cuando él se pronuncie , cuando se entienda como el hacedor de la educación y protagonista del conocimiento pedagógico. Aquí el maestro y los demás miembros de la “comunidad educativa” fueron invitados al pronunciamiento sobre la escuela

Biochemical markers of bone turnover and clinical outcome in patients with renal cell and bladder carcinoma with bone metastases following treatment with zoledronic acid: The TUGAMO study

Background: Levels of bone turnover markers (BTM) might be correlated with outcome in terms of skeletal-related events (SRE), disease progression, and death in patients with bladder cancer (BC) and renal cell carcinoma (RCC) with bone metastases (BM). We try to evaluate this possible correlation in patients who receive treatment with zoledronic acid (ZOL). Methods: This observational, prospective, and multicenter study analysed BTM and clinical outcome in these patients. Serum levels of bone alkaline phosphatase (BALP), procollagen type I amino-terminal propeptide (PINP), and beta-isomer of carboxyterminal telopeptide of type I collagen (b-CTX) were analysed. Results: Patients with RCC who died or progressed had higher baseline b-CTX levels and those who experienced SRE during follow-up showed high baseline BALP levels. In BC, a poor rate of survival was related with high baseline b-CTX and BALP levels, and new SRE with increased PINP levels. Cox univariate analysis showed that b-CTX levels were associated with higher mortality and disease progression in RCC and higher mortality in BC. Bone alkaline phosphatase was associated with increased risk of premature SRE appearance in RCC and death in BC. Conclusion: Beta-isomer of carboxy-terminal telopeptide of type I collagen and BALP can be considered a complementary tool for prediction of clinical outcomes in patients with BC and RCC with BM treated with ZOLNovartis Oncology Spain for supporting this stud

Usefulness of bone turnover markers as predictors of mortality risk, disease progression and skeletal-related events appearance in patients with prostate cancer with bone metastases following treatment with zoledronic acid: TUGAMO study

Owing to the limited validity of clinical data on the treatment of prostate cancer (PCa) and bone metastases, biochemical markers are a promising tool for predicting survival, disease progression and skeletal-related events (SREs) in these patients. The aim of this study was to evaluate the predictive capacity of biochemical markers of bone turnover for mortality risk, disease progression and SREs in patients with PCa and bone metastases undergoing treatment with zoledronic acid (ZA). Methods: This was an observational, prospective and multicenter study in which ninety-eight patients were included. Patients were treated with ZA (4mg every 4 weeks for 18 months). Data were collected at baseline and 3, 6, 9, 12, 15 and 18 months after the beginning of treatment. Serum levels of bone alkaline phosphtase (BALP), aminoterminal propeptide of procollagen type I (P1NP) and beta-isomer of carboxiterminal telopeptide of collagen I (b-CTX) were analysed at all points in the study. Data on disease progression, SREs development and survival were recorded. Results: Cox regression models with clinical data and bone markers showed that the levels of the three markers studied were predictive of survival time, with b-CTX being especially powerful, in which a lack of normalisation in visit 1 (3 months after the beginning of treatment) showed a 6.3-times more risk for death than in normalised patients. Levels of these markers were also predictive for SREs, although in this case BALP and P1NP proved to be better predictors. We did not find any relationship between bone markers and disease progression. Conclusion: In patients with PCa and bone metastases treated with ZA, b-CTX and P1NP can be considered suitable predictors for mortality risk, while BALP and P1NP are appropriate for SREs. The levels of these biomarkers 3 months after the beginning of treatment are especially importantThis study was supported by Novartis Oncology Spai

Expedición Pedagógica Nacional. Aproximaciones a las memorias del conflicto armado desde la escuela

La guerra y la paz en la escuela y sus memorias en tiempos de acuerdo y posacuerdo atraviesan las páginas de este libro. Textos producidos por miembros del Movimiento Expedición Pedagógica Nacional Bogotá y de algunas de las organizaciones aliadas a este movimiento para hacer visible la memoria del conflicto armado y las iniciativas de paz desde la escuela en Bogotá son estas: Colectivo de Historia Oral, Colectivo de Pedagogías Críticas y Alteridad y Planeta Paz