Design and evaluation of Moringa oleifera loaded transferosome vesicles: In vitro characterization

Moringa oleifera  herb is widely found in western ghat. The anticancer potential especially against breast cancer is proved by many scientific investigators. However poor skin permeability of active constituents limits the therapeutic use of this herbal active. Transfersomes are modified liposomes with improve skin permeation ability. Thus, extract loaded transfersomes were formulated to improve skin permeation of extract. The transfersomes are phospholipid based vesicles with edge activators. The edge activators increase skin permeation of transfersomes. The extract loaded transfersomes were fabricated using thin film hydration and assessed for vesicle size, microscopic imaging and thermal behavior. The transfersomes showed acceptable vesicle size and zeta potential. Thus, formulated transfersomes could be promising alternative for skin permeation enhancement of herbal active

Micromachining of various metals by using Acidithiobacillus ferrooxidans 13820 culture supernatant experiments

a b s t r a c t The aim of the work reported in this paper is to develop a new method for micromachining of metals. This work demonstrates the potential use of bacterial culture supernatant for the machining of metals. The change in mass of various metals in bacterial culture supernatant was used to quantify the material removal rate. The promising results of present study revealed that the bacterial culture supernatant can be used as a replacement of the toxic FeCl 3 , currently employed for chemical machining. Also this research is important to optimize the formation of patterned copper films

Radiological correlation with functional outcome in displaced proximal humerus fractures treated with locking plates: a prospective study of 35 cases

Background: The objective of this prospective study is to investigate the relationship between the functional outcome and the radiographic results of two-, three- and four part proximal humeral fractures treated with open reduction and fixation with PHILOS locking plate.Methods: 35 patients (30 males and 5 females) with displaced proximal humerus fracture were treated with PHILOS plating and studied prospectively. According to Neer’s classification there were 16 two part fracture (45%), 15 three part fracture (42%) and 4 four part fracture (13%). The healing of fracture, head shaft angle (HSA) and complications were evaluated radiologically with plain radiographs whereas the functional outcome was assessed by the Shoulder Pain and Disability Index (SPADI) at 6 weeks, 3 months, 6 months and 1 year after surgery.Results: In our study, patients treated with locking plates had mean forward flexion of 123°, abduction of 124°, mean external rotation of 30° and internal rotation 53° at 1 year follow-up. Maximum improvement in range of movement occurred between interval of 12 weeks to 24 weeks due to complete fracture union occurred approximately up to 12 weeks. The mean SPADI score at end of 1 year were 10.22, 10.38 and 10.20 for two, three and four part fractures respectively. Average postoperative and follow-up HSA's were 134.1±4.4 and 132.5±1.2 degrees, respectively. Varus progression was more prominent in patients with postoperative HSA <130 (p<0.001). Complications included impingement in 1 case, joint penetration by screw in 1 case, failure of fixation in 1 case and infection in 1 case.Conclusions: Fixed angle locked plate is an extremely useful implant for reconstruction and salvage of proximal humeral fractures. Precise surgical technique, stable fracture fixation and restoration of anatomical reduction are absolutely necessary for improved outcome

A note on the recurring heavy catch of ‘Ghol’, Protonibea diacanthus by dol net at Bassien koliwada, Maharasthtra.

Protonibea diacanthus, locally known as‘Ghol’ is one of the most commercially important fishes of northwest coast of India. The swim bladder of ‘Ghol’ fetches a very high market price as it is considered as one of the best qualities.On 28-10-06 catch of 8820 Kg of ‘Ghol was landed at Bassien koliwada by a dol net boat with an OAL of 15 m fitted with 90 HP engine

Gold sensitized sprayed SnO2 nanostructured film for enhanced LPG sensing

We report LPG sensing of gold (Au)-sensitized SnO2 nanostructured film fabricated by an easy spray pyrolysis deposition method whose surface morphology is confirmed by field-emission scanning electron microscopy and atomic force microscopy images and structure by X-ray diffraction pattern. Energy dispersive X-ray spectrometer analysis has carried out for finding elemental composition. The SnO2 film is uniform and consists of spherical particles of ∼10nm. The highest gas response observed at 780ppm LPG concentration for pristine SnO2 is 28%, at operating temperature 623K, which is greatly improved on Au sensitization up to 57% with 60s rapid response time at 598K operating temperature. The high gas response is due to electronic effect and catalytic spill-over effect of Au sensitization. The improved sensing mechanism has throughly been explored

Management of developmental anomalies in maxillary lateral incisors: A case series

Talons cusp and palate-radicular groove are commonly occurring developmental anomalies in permanent maxillary lateral incisors. These anomalies present with various esthetic and functional complications that require prophylactic and definitive treatment plans. It is essential to have a thorough knowledge of these anomalies for their correct diagnosis and successful management. This case series presents etiology and various treatment modalities for the management of these commonly occurring developmental anomalies in the maxillary lateral incisors

Evaluation of soybean peroxidase - Copper phosphate mediated organic-inorganic hybrid for hydrogen peroxide biosensor application

An electrochemical biosensor for H2O2 detection was developed by using soybean peroxidase-copper phosphate mediated organic inorganic hybrid (OIH). The characterization of OIH was carried out by FESEM and FTIR. FESEM analysis showed a flower-like porous morphology of the OIH and FTIR confirmed the presence of soybean peroxidase and copper phosphate in the OIH. For sensor development, the paste of OIH was formulated in the presence of phosphate buffered saline (PBS) and was screen printed on indium tin oxide (ITO) coated glass substrate. Cyclic voltammetry analysis showed that the developed biosensor could detect H2O2 in the linear range of 20–100 ​μM with R2 value of 0.963. The limit of detection (LOD) and sensitivity values calculated for H2O2 are 0.19 ​μM and 27.44 μA/(μM.cm2) respectively. Along with cyclic voltammetry experiments, electrochemical impedance spectroscopy (EIS) analysis was also carried out to study the sensing mechanism. The developed biosensor showed better selectivity towards H2O2 when tested against d-glucose, l-tyrosine, l-lysine, and l-ascorbic acid

Management of self-inflicted dental injuries with various nonsurgical techniques: Case series

Children have a common habit of exploring carious or traumatically exposed teeth using various foreign objects such as metal screws, staple pins, darning needles, pencil leads, beads, paper clip, and toothpicks, which may sometimes break inside the pulp chamber or root canal. Majority of such cases are asymptomatic and hence diagnosed accidentally on routine radiographic examination. However, embedded foreign objects may sometimes act as a potential source of infection and are convoyed with pain or recurrent swelling. Dentists must be aware of the self-inflicted dental injury, its consequences, and selection of the all-inclusive treatment strategies giving due consideration to cost-benefit ratio of the different treatment options. This case series highlights the possible dental consequences of placing foreign objects in the mouth and various management strategies. Four cases of self-inflicted dental injuries involving patients aged 10–20 years are presented and investigated from the endodontic, pedodontic, and psychiatric viewpoints. In all cases, the cause has been easily identified by clinical appearance corroborated with a good history. This paper discusses a nonsurgical technique to retrieve these objects from the root canal with minimal damage to internal tooth structure