Toxicity study and effect of the leaf extract of Acacia nilotica on some biochemical parameters of Wistar albino rats

Plants are the primary source of human medications and knowledge on its toxicity is vital; this work evaluates the acute toxicity and effect of Acacia nilotica leaf crude extract on the liver and kidney functions. The mean lethal dose (LD50) was determined by Lorke’s method, while the crude extract effect was evaluated by biochemical and histo-pathological assessments. The LD50 value was 3807.89 mg/kg for both oral and intra-peritoneal route of administrations. An elevated serum urea above the normal reference value in both control and treated group upon administration of 1000 mg/kg of the extract with mean values of 7.92 ± 1.19 and 7.86 ± 1.14 mmol/l respectively was observed. The results of ALAT, ASAT, ALP, T.protein, Albumin, and bilirubin in all cases were within the normal values. The kidney and liver function parameters at higher extract concentrations of 500 and 1000 mg/kg/day and relative organ weight were statistically significant (p< 0.05) and correlates with mild effect indicted on the histopathology of the organs. This study showed that administration of A. nilotica extract at 500 and 1000 mg/kg/day for an extended period could prompt hepatic and nephron toxicity

Analysis of a Few Domain Adaptation Methods in Causality

Understanding the effect of intervention is of great importance in many domains such as marketing, governance, health, economics, social science, etc. An ideal approach for estimating the effect of intervention requires conducting experiments which are often unethical, expensive, time consuming, or even impossible; leaving interesting business and research questions un-answered. Nowadays, data from businesses, government databases, and electronic medical records are generated in large amount and at unprecedented rate, making the use of observational study a viable alternative. However, the data posses bias between the treated and the control subjects posing a great challenge for this task. Machine Learning (ML) and Deep Learning (DL) models are recently deployed for causality and have achieved a state of the art results. "Correcting" the bias through aligning the distribution of the treated and control in the form of domain adaptation is shown to be an effective technique for estimating causal parameters. However, most often, these models involve complex DL architectures. There are tons of Domain Adaptation (DA) methods developed to align the shift between the source and target distribution in classical ML. In this thesis, following the Potential Outcome framework with binary treatment setting, we bring the idea of correlation alignment methods, adversarial training, and a parallel two streams architecture from domain adaptation into causality. But we initially built simple baseline Neural Networks (NN) models in each case which are optimized and evaluated. This is to understand the effectiveness and performance of the simple models in causality without any form of distribution alignment mechanisms proposed in domain adaptation literature. Then the DA components of these models are incorporated as an additional loss to the baseline models in each case, and are evaluated on four most widely used benchmarks. Our results show that incorporating additional DA losses are generally not effective for causality. The simple baseline models were able to achieve state-of-the-art results on some metrics. Suggesting that DL models with hyperparameter tuning could estimate causal parameters without necessarily the need for specialized regularizations. Moreover, many of the metrics could be estimated effectively with linear versions of these models. It was found that no method is superior over others on all the datasets. However, methods based on shared weights have fairly performed better than model based on unshared weights. Further more, using geodesic and Euclidean distances for correlation alignments produced similar results, implying some robustness to distance measure

PERCEIVED CORRELATION BETWEEN COMMUNICATION STYLES AND INTERPERSONAL CONFLICT RESOLUTION AMONG INTERNATIONAL STUDENTS IN MALAYSIA

Background and Purpose: A good and fulfilling relationship among individuals from distinct cultural backgrounds depends on effective communication. This research examined the perceived relationship between communication styles and interpersonal conflict resolution among international students in Malaysian universities.   Methodology: The study employed a cross-sectional survey in which self-developed structured questionnaires were used to gather data from a random sample of 324 international students in 15 higher institutions across Kuala Lumpur, Malaysia. The data were analyzed using multiple regression analysis.   Findings: The findings of this study revealed a significant positive relationship between communication styles and interpersonal conflict resolution among international students. Specifically, passive, passive-aggressive, and assertive communication styles have a significant positive relationship with conflict resolution. However, the aggressive communication style exerts an insignificant effect on conflict resolution with a t-value of 0.734 and a P-value of 0.463. Thus, the students generally believe this style does not help to resolve interpersonal conflict. These outcomes suggest the students’ readiness for cultivating a peaceful learning environment.   Contributions: This study provides relevant information that can help educational decision-makers to strengthen cross-cultural collaboration among international students in the Malaysian context. This valuable information can also facilitate successful academic, professional, and social cooperation.   Keywords: Cross-cultural relationship, interpersonal conflict resolution, communication styles, international students, Malaysia.   Cite as: Mohammed, S., Nasidi, Q. Y., Muhammed, M. U., Umar, M. M., & Hassan, I. (2023). Perceived correlation between communication styles and interpersonal conflict resolution among international students in Malaysia. Journal of Nusantara Studies, 8(2), 352-372. http://dx.doi.org/10.24200/jonus.vol8iss2pp352-37

A review on emerging pathogenesis of COVID-19 and points of concern for research communities in Nigeria

Background: COVID-19 remains an emerging pandemic that continuously poses an alarming threat and challenge to economic, social and well-being of the people throughout the world. It also remains an evolving disease which complete pathogenesis that translates into clinical features is only just emerging by each second of the day. There have been observations about the emerging trends of the disease in Nigeria like in any other country in the world where there is outbreak. This study examined from evidence-based literature the emerging pathogenesis of COVID-19 and important points of concern of the disease in Nigeria.Materials and Methods: The paper reviewed published articles in PubMed and Google Scholar using search terms „COVID-19” and “SARS-CoV-2”, as well as searched for general COVID-19 information on internet.Results: The result summarized literature on emerging pathogenesis of COVID-19 and important points of concern as well as research questions as to the peculiar trends of the disease in Nigeria.Conclusion: Pathogenesis of COVID-19 remains an emerging knowledge and there are many important research questions that need to be scientifically answered for a successful containment of COVID-19 in Nigeria. It is recommended that all members of intellectual research communities should join the fight against COVID-19 pandemic

Individual differences in perception and response to experimental pain in a young Nigerian population

Background: Pain is a protective sensation that alerts an individual to injury from the environment. Experience of pain is characterised by robust individual differences and complex environmental and genetic factors lead to individual variations in pain. Studies of experimental pain are free from the confound of disease progression, but can be highly relevant to clinical pain states. The aim of this study is to evaluate individual differences in perception and response to experimental pain among young Nigerian population. Methods: One hundred and thirty apparently healthy subjects (age 12 to 20 years) were used. Pain was accessed using cold pressor test and ischemic pain models. VAS and VRS were used to access pain catastrophizing. Data were presented as mean ± SD. Differences and statistical significance between the means were determined using t test. Values of P < 0.05 were considered significant. Results: The results showed significant differences among the study population in experimental pain threshold and tolerance. Conclusion: The study proved that there is variation in perception and response to experimental pain among secondary school students in Zaria, Northern Nigeri

A REVIEW ON EMERGING PATHOGENESIS OF COVID-19 AND POINTS OF CONCERN FOR RESEARCH COMMUNITIES IN NIGERIA

Background: COVID-19 remains an emerging pandemic that continuously poses an alarming threat and challenge to economic, social and wellbeing of the people throughout the world. It also remains an evolving disease which complete pathogenesis that translates into clinical features is only just emerging by each second of the day. There have been observations about the emerging trends of the disease in Nigeria like in any other country in the world where there is outbreak. This study examined from evidence-based literature the emerging pathogenesis of COVID-19 and important points of concern of the disease in Nigeria. Materials and Methods: The paper reviewed published articles in PubMed and Google Scholar using search terms ‘COVID-19” and “SARS-CoV-2”, as well as searched for general COVID-19 information on internet. Results: The result summarized literature on emerging pathogenesis of COVID-19 and important points of concern as well as research questions as to the peculiar trends of the disease in Nigeria. Conclusion: Pathogenesis of COVID-19 remains an emerging knowledge and there are many important research questions that need to be scientifically answered for a successful containment of COVID-19 in Nigeria. It is recommended that all members of intellectual research communities should join the fight against COVID-19 pandemic

Effect of Micro Economic Factors on Residential Property Value in Birnin Kebbi, Kebbi State, Nigeria

The research aims to assess the microeconomic factors affecting residential property values in Birnin Kebbi. Property serves as an asset for any individual, as real estate is one of life\u27s primary goals. Besides the need to eat and drink, property also plays a crucial role in daily life. Property values are influenced by various factors, which can be either microeconomic or macroeconomic in nature, or both. Many microeconomic variables are related to property attributes and buyer demographic profiles. To achieve this aim, two objectives were formulated: (i) to examine the types of property and microeconomic factors affecting property values in the study area, and (ii) to assess the effect of microeconomic factors on residential property values. Both primary and secondary sources of data were used for data collection. Out of 377 questionnaires administered, 321 were retrieved. Simple random sampling and stratified random sampling methods were employed. Quantitative methods were used for data analysis, and all data gathered were analysed using descriptive statistics and the Likert scale. The study found that physical characteristics of residential properties, such as types of materials used, building design, room sizes, parking spaces, building age, and landscape, significantly influence property values. Additionally, the types of finishes (roofs, walls, ceilings, and floors), infrastructural facilities, and social amenities (number of toilets, electricity fittings, waste disposal and sewage, potable water supply, and various sanitation facilities) also play a role. The effects of microeconomic variables on property values in the study area include insecurity, increased traffic, property price changes, nuisances, environmental quality, property demand, and time consumption. The study recommends that prospective property developers ensure the use of standard building finishes to maximize returns on their investment in property value. Additionally, the government should introduce policies to ease difficulties in importing housing materials and promote the manufacture of local ones

Comparative study of the level of bacterial/helminths contamination of vegetables produced from polluted and unpolluted irrigation site of Kano

A comparative study was contaminations of five major crops (Lactuca veriso, Darcus carota, Solanum lycopersicum, Phylanthus amarus, Alium cepa) produced from polluted (industrial/residential effluents) Sharada and unpolluted (tube well water)Yarimawa using the method described by FAO, (1979). The result shows that the five crops, produced with polluted water viz, Lactuca veriso, Darcus carota, Solanum lycopersicum Phylanthus amarus, Alium cepa, had mean aerobic plate count of 2.0 x 102 cfu/g, 8.40 x 102 cfu/g , 1.13 x 103 cfu/g , 5.8 x 104 cfu/g cfu/g, 5.7 x 101 cfu/g, respectively, and all the five crops had mean coliform count of 180 MPN/g, while that of unpolluted water had mean aerobic plate count of of 1.22 x 102 cfu/g 5.1 x 102 cfu/g , 1.4 x 102 cfu/g, 1.43 x 102 cfu/g, 1.32 x 101 cfu/g respectively, and had mean coliform count of 30, 21,21, 21 and 21MPN/g respectively. The organisms isolated in all the crops produced with polluted water were E. coli, Salmonella sp, Shigella sp, S. aureus, Ascaris egg, Strongloides and Ancylostoma while E. coli, Shigella sp, S. aureus, wer the organisms isolated in the crops produced with unpolluted water, only Lactuca verosa and Solanum lycopersicum, shows the presence of helmiths in the crops produced with the unpolluted water.Key words: Kano, Bacteria, Helminth, effluent, Yarimawa, Sharad

Potential and Accuracy of Hand Length and Hand Breadth in Sex Determination: An Insight into Hausa Population of Nigeria

The identification of an individual in mass disasters and traffic accidents is a fundamental goal in forensic investigations. However, it is suggested that every population needs anthropological reference data. The objectives of this study were to determine the potential and accuracy of hand length and hand breadth in sex determination among the Hausa population of Nigeria. Random sampling was employed to select 204 male and 194 female subjects aged 18-30 years. Hand length and hand breadth were measured using standard protocols. Two-sample t-test, binary logistic regression, receiver operating characteristics curve, and Youden’s index were used for determining sex using hand dimensions. Posterior probability and likelihood ratio were used to determine the favor odds of each category of hand dimension in sex discrimination. A significant sexual dimorphism was observed in hand length and hand breadth with higher mean values in males. The variance of sex explained by hand parameters ranges from 38.50/51.35% (lower/upper limits) to 52.98/70.66%, which were exhibited by right hand length and left hand breadth respectively. The overall prediction and percentage accuracy of sex discrimination ranges between 80.40 to 86.70 % that were exhibited by right hand length and handbreadth respectively. We observed that left hand breadth exhibited higher Younden’s index with an area under curve (AUC) ranging from 91.60% to 96.05%. We found that hand length of > 189.99 mm was indicative of male origin and hand breadth of > 79.99 mm was indicative of male origin

Lower Pitch Voice Produce by Effort Sound in Previously Uvulectomized Children

The palatine uvula is conic projection composing of soft connective tissue which has a number of racemose glands. It hangs from the posterior edge of the middle of the soft palate of the roof of the mouth. It has circular muscle fibres at its base and helps in closing the nasopharynx during deglutition. Copious secretion from the uvula helps moisten the larynx and vocal cord to maintain quality speech. In the Hausas’ culture in Northern Nigeria, the uvula is highly demonized and blamed for a lot of health problems and risk of death and so all infants must ‘proactively’ undergo uvulectomy on the 7th day after birth, with few exceptions.  This study aims at evaluating the effect of uvulectomy on pitch quality of effort sounds of young children between 2 to 11 years of age. Eighty subjects were divided into two groups of 40 uvulectomized and 40 non-uvulectomized children which were further subdivided into various age ranges of equal mix of male and female. Audio frequency analyzer software is used to conduct the test and the result shows a reduction in frequency of the sounds produced by uvulectomized subjects, p<0.05. Uvulectomy does affect the quality of sound produced in children giving a significant lower pitch quality. Keywords: Uvula, Uvulectomy, Effort Sound, Frequency, Pitch DOI: 10.7176/JHMN/90-01 Publication date:June 30th 202