Ontology Based E-Healthcare Information Retrieval System: A Semantic Approach

With the increase of data in the health care system provides a base for the development of an effective information retrieval system. The implementation of such information retrieval system integrates the heterogeneous information from the healthcare environment. Most of the existing information retrieval systems are syntactic based systems, which will provide inefficient results for the search queries. The objective of this approach is to design a semantic based E-Healthcare information retrieval system. The proposed approach uses an ontology to define the disease-treatment information and will be used for the effective information retrieval. The designated approach is evaluated with a web based tool and the results shows that there is an improvement in the approach

Antibiotics prescribing pattern in the in-patient departments of a tertiary care hospital

Context: Antibiotic prescribing by physicians has gained due importance across the globe, mainly because of an increase in antibiotic usage, prevalence of infections, and drug resistances. Aims: The present study aimed to evaluate the prescribing pattern of antibiotics, their adherence to essential medicines list, disease conditions for which they were prescribed, and their adverse effects. Settings and Design: A cross-sectional prospective study was carried out in six inpatients departments (Surgery, Orthopedics, ENT, Ophthalmology, Medicine, and Pediatrics) of a 550-bed tertiary care hospital in Trivandrum, India for two months (July-August 2012). Institutional Research and Ethics Committee clearance were obtained prior to the study. Materials and Methods: The data were collected in a predesigned performa from the medical case sheets, drug charts, and laboratory investigations of 100 in-patients. The enrolled patients were observed from admission till discharge. Descriptive statistics were applied to the collected data and analyzed using Microsoft Excel software. Results: The mean duration of hospitalization among the study population was 5.48 (±4.28) days. Of the 410 medicines prescribed, antibiotics contributed 151 (36.8%). They were mostly indicated for respiratory infections, and the most common antibiotic was Beta-lactams (91 (60.2%). Interestingly, 89 antibiotics (60%) were administered as injections. About 70 (46%) of the antibiotics were prescribed without any combinations. The adherences to World Health Organization′s essential medicines list were 122 (81%). A total of seven adverse drug reactions were reported in the current study. Of which, none were serious, and five (70%) were cutaneous reactions. Conclusions: Of the 100 patients analyzed from six in-patient departments, it was observed that the hospital physicians prescribed antibiotics more rationally with no banned drugs and less newer drugs. Rational prescribing of antibiotics would help avoid polypharmacy and prevent drug resistances

Scandium triflate immobilized in ionic liquids: a novel and recyclable catalytic system for hetero-Diels-Alder reactions

Cyclic enol ethers such as 3,4-dihydro-2H-pyran (DHP) and 2,3-dihydrofuran (DHF) undergo [4+2] cycloaddition reactions with imines (generated in situ from aryl amines and enol ethers) in the presence of 3 mol% scandium triflate immobilized in 1-butyl-3-methylimidazolium hexafluorophosphate under solvent-free conditions to afford the corresponding pyrano- and furo[3,2-c]quinolines in high yields

Glaser oxidative coupling in ionic liquids: an improved synthesis of conjugated 1,3-diynes

Terminal alkynes undergo oxidative-coupling smoothly in the presence of the CuCl-TMEDA catalytic system in hydrophobic [bmim]PF6 ionic liquid under aerobic conditions to produce 1,3-diynes in excellent yields under mild conditions. The substrates, alkynes, show enhanced reactivity and selectivity in ionic liquids (ILs). The recovery of the catalyst is facilitated by the hydrophobic nature of the [bmim]PF6 ionic liquid

The stereoselective total synthesis of xestodecalactone C and epi-sporostatin via the Prins cyclisation

Syntheses of xestodecalactone C and epi-sporostatin are described utilising Prins cyclisations, Mitsunobu reaction and intramolecular Friedel-Crafts acylation. The approach is convergent and highly stereoselective

First stereoeselective total synthesis of sporostatin and determination of absolute configuration

The first simple and efficient total synthesis of sporostatin has been accomplished in five steps starting from (S)-propylene oxide. The synthesis utilizes simple reactions such as esterification, cross-metathesis, and intramolecular Friedel-Crafts reaction as key steps