Effects Of Pilates And Yoga In Patients With Chronic Neck Pain: A Sonographic Study

Background: Various studies have shown the efficacy of conventional isometric, Pilates and yoga exercises. However, data on the effects and comparison of these specific exercises on the cervical muscle morphology are insufficient or lacking. Objective: To investigate the effects of different exercise treatments on neck muscles in patients with chronic neck pain. Design: A randomized study. Methods: Fifty-six patients with chronic neck pain were randomized into 3 groups as follows: Pilates group (n = 20), yoga group (n = 18) and isometric group (n = 18). Demographics and background information were recorded. The thickness and crosssectional area of neck muscles were evaluated by ultrasound imaging. Cervical motions were measured with a goniometer. Pain severity was evaluated with the McGill Pain Scale, disability with the Neck Disability Index, quality of life with the Nottingham Health Profile, and emotional status with the Beck Depression Inventory. In addition to a conventional physiotherapy programme, 15 sessions of physical therapy, including hot pack, ultrasound, and transcutaneous electrical nerve stimulation (TENS), were provided to all patients. All groups performed the exercises for 6 weeks. The aforementioned assessments were performed before and 6 weeks after the treatment. Results: Although pain, disability, depression and quality of life improved similarly within all groups (all p < 0.05), muscle thickness values as regards the semispinalis capitis were increased only in the Pilates group (p = 0.022). Study limitations: The lack of complex (progressive resistive) exercise treatment protocols, short treatment duration and partial supervision. Conclusion: All 3 types of exercise had favourable effects on pain and functional scores, but no differences were found among the groups, except for the Pilates group, in which the semispinalis capitis muscle increased in thickness.WoSScopu

Apoptotic and necrotic effects of carboxylated quercetin/polyethylenimine complex on HeLa cells

WOS: 000295799500013The effects of quercetin (Q), carboxylated quercetin (CQ) and carboxylated quercetin/polyethylenimine (CQ/PEI) complex on HeLa cell cultures were investigated. Firstly, carboxylated quercetin was acquired through hydroxyl groups of quercetin, using chloroacetic acid. The complex of CQ/PEI was acquired by electron cooperation path over polietilenimine amine groups and quercetin carboxyl groups. CQ and CQ/PEI obtained were characterised by FTIR and H-1-NMR methods. Cytotoxicity was determined by MTT assay. Apoptotic and necrotic indexes were obtained by immunocytochemical staining with the M30 antibodies and double staining and double staining, respectively. It was determined that quercetin caused lower rates of necrosis and apoptosis on HeLa cells by itself, but CQ/PEI complex resulted in high levels. As a result, it was observed that transition of quercetin to HeLa via binding it to polyethylenimine increased its anticarcinogenic effects.Kirikkale University Science Research FoundationKirikkale University [2007/70]; Kirikkale University of TurkeyKirikkale UniversityThis work was supported by Kirikkale University Science Research Foundation Project (number; 2007/70) of Kirikkale University of Turkey

Late Quaternary sea-level change, sedimentation and neotectonics of the Gulf of Gokova: Southeastern Aegean Sea

The sedimentary and tectonic Late Quaternary evolution of the Gulf of Gokova located at the southwest Anatolia-southeastern Aegean Sea region has been interpreted from 800 line km of 3.5 kHz and single channel airgun seismic reflection profiles. The older part of the Gokova basin is formed by mainly E-W trending faults and filled by the latest Miocene-Pliocene-Quaternary hemipelagic sediments with thickness up to 2.5 km. The Lycian Nappes, which primarily cover extreme southwestern Anatolia, represent the basement rocks for the Gokova region. Younger active faulting so-called Gokova Transfer Fault (GTF), which has not been previously discussed in the literature, trends NE in the central part of the Gulf of Gokova basin and records sinistral strike-slip motion broadly parallel to the convergence direction of the Aegean-Anatolian and African plates. The continental shelf of the northeastern Gulf of Gokova is mostly formed by numerous superimposed deltaic successions (depositional sequences), separated by major erosional unconformities. During times of lowered sea-level associated with late Quaternary glaciations, deltas prograded more than 40 km seaward from their present positions. Foreset progradation terminated with the rise of sea level in interglacial and post-glacial times and deltas were relocated far inland. These major transgressions resulted in unconformities that are correlated with the beginning of oxygen isotope stages 9, 7, 5 and 1, and provide chronostratigraphic markers for a detailed analysis of sedimentation patterns in the late Quaternary. All seismic lines show that the topset to foreset transition of the youngest Pleistocene delta system developed around 145-150 ms below present sea-level. Thus, the maximum Pleistocene sea-level lowering (18 000 years BP) was about -110 m. The positions of maximum regression for isotopic stages 6, 8 and 10 were found as 160, 190 and 215 in below present sea-level, respectively. Paleo shoreline positions during isotopic stages 2, 6 and 8 suggest an overall gradual subsidence of Gokova basin, during the last 0.5 Ma in the southeastern Aegean Sea. The seismic sedimentary chronology suggests that the Gokova Basin is subsiding at 0.3-0.4 mm/year. Three bathymetric low and E-W, WNW-ESE directed two main ridges in the gulf area are noticeable from the bathymetric data and are well correlated to the seismic data. While the main orientation of the gulf is E-W, more recent ENE-WSW and WNW-ESE structures are remarkable in the western and the mid-eastern part of the gulf respectively. Subsidence rates are greatest in the southern center of the basin and decrease northward, so that the northern area is being tilted southward. (c) 2005 Elsevier B.V All rights reserved

Comparing COVID-19 RT-PCR results, thorax computed tomography findings, and laboratory results of patients admitted to emergency medicine clinic with clinical symptoms of COVID-19 disease

In December 2019, cases of pneumonia of unknown origin were detected in Wuhan, Hubei Province, China. It was later determined that the pathogen SARS-CoV, which causes these cases of pneumonia, has been identified as the new enveloped RNA Betacoronavirus 2, now called severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2). In Turkey, the first case was detected on March 10, 2020. This study aimed to evaluate the factors that will enable rapid diagnosis of the disease through comparison of COVID-19 RT PCR results, thorax computed tomography (CT) findings, and laboratory results of patients suspected with COVID-19 who visited Başkent University Ankara Hospital Emergency Medicine Clinic. In our sample of 515 patients (280 female and 235 male patients), infiltration was detected in 113 patients (21.9%) The ratio of females to males increased with age. When the sex distribution of the thoracic CT findings was examined, the incidence of infiltration was higher in male patients. Conversely, no statistically significant dependence was found between the two categories using the chi-squared test. Shortness of breath was observed in 32.7% of patients with positive thoracic CT findings. Other common complaints were chest pain, 12.4%; fever, 10.6%; and weakness, 9.7%, respectively. The other category, which covered unclassified arrival complaints, had the highest percentage in the entire sample. When the thoracic CT distribution of comorbidities was examined (hypertension, 29.2% and diabetes, 25.2%) were more common than the other comorbidities in terms of the presence of infiltration. Thoracic CT results with RT-PCR, which were analyzed using the chi-square test, showed a statistically significant dependence between them. Conversely, COVID-compatible thorax CT findings were detected in 80 of 260 patients who tested negative in the PCR test. No complaints of fever, cough, weakness, shortness of breath, or chest pain associated with COVID were found in 48.6% of patients who were thoracic CT positive. PCR showed a low sensitivity rate. Therefore, thoracic CT is a better choice than PCR for the detection of asymptomatic cases in emergency patients. Because its selectivity rate is high, using PCR as a diagnostic test is more significant. [Med-Science 2023; 12(3.000): 741-5

Daptomycin vs. glycopeptides in the treatment of febrile neutropenia: results of the Izmir matched cohort study

WOS: 000462946100012PubMed ID: 30498901PurposeIn this multicentre, retrospective, matched cohort study we aimed to evaluate the outcomes of neutropenic fever cases that were treated with daptomycin or a glycopeptide (vancomycin or teicoplanin).MethodsData and outcomes of adult (aged>18-years old) patients with neutropenic fever [(1) without clinical and radiological evidence of pneumonia, (2) who were treated with daptomycin or a glycopeptide (teicoplanin or vancomycin) for any reason and for at least 72 h] were extracted from the hospital databases. Matching was performed with all of the three following criteria: (1) underlying disease, (2) reason for starting daptomycin or glycopeptide (microbiologic evidence vs. microbiologic evidence, clinical infection vs. clinical infection and empirical therapy vs. empirical therapy) and (3) neutropenic status.ResultsOverall 128 patients [(69/123) (56.1%) in the daptomycin cohort (D) and 59/123 (48%) in the glycopeptide cohort (G)] had a resolution of fever at the end of 72h antibiotic treatment (p=0.25). There was no significant difference in cured, improved and (cured+improved) rates between (D) and (G) cohorts as well as fever of unknown origin cases or microbiologically confirmed infections or clinically defined infections subgroups (p>0.05). There was also no significant difference (p>0.05), in terms of persistent response in the (D) versus (G) cohorts,ConclusionsThese findings suggest that although not better, daptomycin efficacy is comparable to vancomycin if used as empiric therapy in the treatment of adult febrile neutropenia. We conclude that daptomycin may be used at least as a salvage therapy alternative to glycopeptides in the treatment of adult febrile neutropenia cases. A large, randomized-controlled trial may further consolidate the evidence related to this question

Predictive Factors for Determining the Clinical Severity of Pediatric Scorpion Envenomation Cases in Southeastern Turkey

Objective.-The aim of this study was to define the epidemiological, clinical, and laboratory manifestations of scorpion envenomation and to identify factors that are predictive of severe cases

Brucellosis in pregnancy: results of multicenter ID-IRI study

WOS: 000471726700008PubMed ID: 30989418Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. All consecutive pregnant women diagnosed with brucellosis in 23 participating hospitals were included. Epidemiological, clinical, laboratory, therapeutic, and outcome data along with the assessment data of the neonate were collected using a standardized questionnaire. Data of 242 patients were analyzed. The OC rate was 14.0% (34/242) in the cohort. Of the 242 women, 219 (90.5%) delivered at term, 3 (1.2%) had preterm delivery, 15 (6.2%) aborted, and 5 (2.1%) had intrauterine fetal demise. Seventeen (7.0%) of the newborns were considered as low birth weight. Spontaneous abortion (6.1%) was the commonest complication. There were no maternal or neonatal deaths and pertinent sequelae or complications were not detected in the newborns. Splenomegaly (p=0.019), nausea and/or vomiting (p41IU/L; p=0.025), oligohydramnios on ultrasonography (p=0.0002), history of taking medication other than Brucella treatment during pregnancy (p=0.027), and Brucella bacteremia (p=0.029) were the significant factors associated with OCs. We recommend that pregnant women with OC or with fever should be investigated for brucellosis if they live in or have traveled to an endemic area