Normal over rezervi olan ve long protokol uygulanan İVF hastalarında rekombinant fsh ve yüksek derecede saflaştırılmış hmg kullanımının gebelik sonuçlarına etkisinin karşılaştırılması]

Objective: Gonadotropins used in controlled ovarian stimulation have been increasing in number. Beside the recombinant preparations such as rec-FSH, rec-LH and h-hMG human-derived preparations have entered the market. We decided to compare the effects of rec-FSH and HP-hMG with GnRHa on embryo quality and pregnancy outcome in women undergoing an IVF cycle. Material and Methods: In this study, data of 87 patients who had applied to our center from 2007 to 2008 and who had met all inclusion criteria, were analyzed. The patients underwent controlled ovarian hyperstimulation with HP-hMG, rec-FSH following down-regulation with a GnRHa in a long protocol, selected according to determined criteria and acquired embryo via IVF transfer. Results: Of the 87 patients, 44 were stimulated with rec-FSH and 43 with HP-hMG. Distribution of infertility causes was similar between the groups. Duration of gonadotropin administration (p=0.677, Student's t-test) and the total dose of gonadotropin received (p=0.392, Student's t-test) were similar between the two groups. The fertilization rate of the rec- FSH group was significantly higher than the HP-hMG group (p=0.001, Mann-Whitney U test). No significant differences were observed between the study groups in biochemical, clinical and ongoing pregnancy parameters. Conclusion: The higher oocyte yield with rec- FSH does not result in higher quality embryos. LH activity in combination with FSH activity positively affected the oocyte and embryo maturation. Therefore, when we consider the clinical and ongoing pregnancy rates there is no inferiority of HP-hMG in controlled ovarian stimulation

Comparison of maternal and neonatal outcomes in women with HELLP syndrome and women with severe preeclampsia without HELLP syndrome

Objective: To examine and to compare postpartum maternal and neonatal complications and morbidities in women with HELLP syndrome (HELLP group) and women with severe preeclampsia without HELLP syndrome (severe preeclamptic group)

Predictive factors influencing pregnancy rates after intrauterine insemination

Background: So far, many studies investigated factors that affect pregnancy rates after intrauterine insemination (IUI). Various investigators have not agreed on the nature and ranking of these criteria. Objective: The aim of this study was to assess the predictive factors for pregnancy rate after controlled ovarian hyperstimulation (COH)/ IUI. Materials and Methods: Retrospective study of all patients undergoing IUI at Zeynep Kamil Gynecologic and Pediatric Training and Research Hospital from January 2006 to December 2009. In total 980 IUI cycles in 569 couples were analyzed. All women in the study underwent ovarian stimulation using gonadotropin and IUI was performed 36 h after triggering ovulation. The primary outcome measure was clinical pregnancy rates. Predictive factors evaluated were female age, body mass index (BMI), duration of infertility, type of infertility, follicle stimulating hormone (FSH) level and estradiol (E2) on third day of the cycle, number of preovulatory follicles, endometrial thichness, total motil sperm (TMS) count, and ratio of progressive motile sperm. Results: The overall clinical pregnancy rate was 4.7%. Among the predictive factors after multivariate logistic regression analysis level of BMI (<25 kg/m²), number of preovulatory follicles (≥2), level of FSH (<9.4 IU/L), level of E2 (<80 pg/ml) and the ratio of progressive motile sperm (>50%) significantly influenced the clinical pregnancy rate. Conclusion: Level of BMI, FSH, estradiol, number of preovulatory follicles and the ratio of progressive motile sperm may determine IUI procedure as optimum treatment model

Unusual prenatal case with multiple marker chromosomes

Here we report a prenatal case with clonally present different marker chromosomes with GTG banding in multiple cell lines cultured from amniotic cells obtained at 18 weeks of gestation. The amniocentesis was performed because of an increased risk for Down syndrome based on a first trimester screening test but without ultrasonographically detected features. Fetal karyotype was 47õ50,XX,+mar1, +mar2,+mar3[cp50]. CBG and NOR banding showed that all markers had one centromere and no satellites. One of the markers had an unstained region on both arms with CBG banding. Both parents were found to have normal karyotypes. FISH analysis by multiprobe (cytocell) revealed marker chromosomes derived from chromosome 3, 7, and 8. The pregnancy was terminated after genetic counselling. The Fetus presented a small ventricular septal defect, cliteromegaly, and pulmonary segmental defects on autopsy examination following termination at 22 weeks of gestational age. Cytogenetic analysis of skin fibroblasts confirmed these results

İleri malzemelerde elektronlardan mikroyapıya

TÜBİTAK TBAG01.11.1999In this work, the thermodynamical and mechanical properties of Au, Ag, Cu, Ni, Pt and Rh fcc metals and Pt-Rh, Ag-Au and Ni-Cu binary alloys are investigated. The Molecular Dynamics (MD) simulation method is used for this purpose. The most important input for MD-computation, the interatomic interaction potential is chosen to be the Sutton-Chen potential based on the tight-binding formalism. The temperature and density dependence of thermodynamic and mechenical properties are investigated in detail. The simulation results are in agreement with the available experimental results

Iniencephaly with mediastinal bronchogenic cyst: A case report

Objective: Iniencephaly is a rare neural tube defectwith consisting of a defect in the occipital bone,spina bifida of many vertebrae, and retroflexion of the head on the spine. In majorty of cases it is a le-\thal condition

COVID-19 Hastalarında Hastalık Şiddeti ile Viral Döngü Eşik Değeri Arasındaki İlişkinin Değerlendirilmesi

Objective: There is a positive and significant relationship between severity and viral load in some viral diseases. Studies on the relationship between SARS-CoV-2 viral load at diagnosis and severity of coronavirus disease-2019 (COVID-19) have yielded conflicting results. Therefore, we aimed to evaluate the relationship between viral load and the clinical status of patients with COVID-19. Methods: Data of the patients diagnosed with COVID-19 and admitted to our center between May 01 and June 31, 2020, were retrospectively reviewed. The patients were divided into two groups according to their clinical characteristics as mild-moderate and severe. The demographic, laboratory, clinical, and radiological data were retrieved from electronic folders. Results: The entire cohort included 285 patients; 254 had a mild-moderate clinical course, and 31 had a severe course. Statistical analyses revealed that SARS-CoV-2 viral load was not associated with symptom duration and clinical status (p>0.05). According to multivariate logistic regression analysis, only ferritin, C-reactive protein, and lactate dehydro-genase elevations were positively correlated with severe clinical course. (p<0.05). Conclusion: We do not recommend using viral load to predict disease severity in COVID-19. We also found that only ferritin, C-reactive protein, and lactate dehydrogenase accompanied severe clinical course. © 2022, DOC Design and Informatics Co. Ltd.. All rights reserved