Ein Schulprogramm demokratisch entwickeln. OSZ II - Wirtschaft und Verwaltung Potsdam, Brandenburg

Zur Profilierung als ein zukunftsorientiertes und gefragtes Oberstufenzentrum entschloss sich das OSZ II Wirtschaft und Verwaltung Potsdam, sein Schulprogramm auf demokratischer Basis zu entwickeln. Die Schule fragte alle Beteiligten nach den Stärken und Schwächen des OSZ. Auf dieser Grundlage erarbeiteten die Lehrer/-innen in einem längeren Diskussionsprozess die konkreten Ziele für ihre Schulentwicklung

Further evidence for CCN aerosol concentrations determining the height of warm rain and ice initiation in convective clouds over the Amazon basin

We have investigated how aerosols affect the height above cloud base of rain and ice hydrometeor Initiation and the subsequent vertical evolution of cloud droplet size and number concentrations in growing convective cumulus. For this purpose we used in situ data of hydrometeor size distributions measured with instruments mounted on HALO aircraft during the ACRIDICON CHUVA campaign over the Amazon during September 2014. The results show that the height of rain initiation by collision and coalescence processes is linearly correlated with the number concentration of droplets nucleated at cloud base

Universal finite-size scaling amplitudes in anisotropic scaling

Phenomenological scaling arguments suggest the existence of universal amplitudes in the finite-size scaling of certain correlation lengths in strongly anisotropic or dynamical phase transitions. For equilibrium systems, provided that translation invariance and hyperscaling are valid, the Privman-Fisher scaling form of isotropic equilibrium phase transitions is readily generalized. For non-equilibrium systems, universality is shown analytically for directed percolation and is tested numerically in the annihilation-coagulation model and in the pair contact process with diffusion. In these models, for both periodic and free boundary conditions, the universality of the finite-size scaling amplitude of the leading relaxation time is checked. Amplitude universality reveals strong transient effects along the active-inactive transition line in the pair contact process.Comment: 16 pages, Latex, 2 figures, final version, to appear in J. Phys.

Standing genetic variation fuels rapid evolution of herbicide resistance in blackgrass

DATA, MATERIALS, AND SOFTWARE AVAILABILITY : Raw data including PacBio CLR and Iso-seq reads, Illumina PCR-free, Hi-C, and RNA-seq reads can be accessed in the European Nucleotide Archive (ENA; https://www.ebi.ac.uk/ena/browser/ home) under project accession number PRJEB49257 (78), assembly accession CASDCE010000000 (79). Raw ddRAD-seq data for the population study, and PacBio CCS q20 reads can be downloaded from the ENA project accession number PRJEB49288 (80). Annotation files for the genome assembly, the SNP matrix for the ddRAD-seq experiment, and the fasta files with the haplotypes of ACCase and ALS can be found at https://doi.org/10.5281/zenodo.7634530 (81). Scripts and experimental protocols to reproduce the analyses in this study are deposited in the GitHub repository of this study (https://github.com/SonjaKersten/ Herbicide_resistance_evolution_in_blackgrass_2022) (82).Repeated herbicide applications in agricultural fields exert strong selection on weeds such as blackgrass (Alopecurus myosuroides), which is a major threat for temperate climate cereal crops. This inadvertent selection pressure provides an opportunity for investigating the underlying genetic mechanisms and evolutionary processes of rapid adaptation, which can occur both through mutations in the direct targets of herbicides and through changes in other, often metabolic, pathways, known as non-target-site resistance. How much target-site resistance (TSR) relies on de novo mutations vs. standing variation is important for developing strategies to manage herbicide resistance. We first generated a chromosome-level reference genome for A. myosuroides for population genomic studies of herbicide resistance and genome-wide diversity across Europe in this species. Next, through empirical data in the form of highly accurate long-read amplicons of alleles encoding acetyl-CoA carboxylase (ACCase) and acetolactate synthase (ALS) variants, we showed that most populations with resistance due to TSR mutations—23 out of 27 and six out of nine populations for ACCase and ALS, respectively—contained at least two TSR haplotypes, indicating that soft sweeps are the norm. Finally, through forward-in-time simulations, we inferred that TSR is likely to mainly result from standing genetic variation, with only a minor role for de novo mutations.The Landesgraduiertenförderung (State Graduate Scholarship, LGFG) of the State of Baden-Württemberg; a Human Frontiers Science Program Long-Term Fellowship, BASF and the Max Planck Society.https://www.pnas.org/am2024Biochemistry, Genetics and Microbiology (BGM)SDG-15:Life on lan

Further evidence for CCN aerosol concentrations determining the height of warm rain and ice initiation in convective clouds over the Amazon basin

We have investigated how aerosols affect the height above cloud base of rain and ice hydrometeor Initiation and the subsequent vertical evolution of cloud droplet size and number concentrations in growing convective cumulus. For this purpose we used in situ data of hydrometeor size distributions measured with instruments mounted on HALO aircraft during the ACRIDICON CHUVA campaign over the Amazon during September 2014. The results show that the height of rain initiation by collision and coalescence processes is linearly correlated with the number concentration of droplets nucleated at cloud base

High-Dose Chemotherapy Followed by Autologous Stem Cell Transplantation for Metastatic Rhabdomyosarcoma—A Systematic Review

INTRODUCTION: Patients with metastatic rhabdomyosarcoma (RMS) have a poor prognosis. The aim of this systematic review is to investigate whether high-dose chemotherapy (HDCT) followed by autologous hematopoietic stem cell transplantation (HSCT) in patients with metastatic RMS has additional benefit or harm compared to standard chemotherapy. METHODS: Systematic literature searches were performed in MEDLINE, EMBASE, and The Cochrane Library. All databases were searched from inception to February 2010. PubMed was searched in June 2010 for a last update. In addition to randomized and non-randomized controlled trials, case series and case reports were included to complement results from scant data. The primary outcome was overall survival. A meta-analysis was performed using the hazard ratio as primary effect measure, which was estimated from Cox proportional hazard models or from summary statistics of Kaplan Meier product-limit estimations. RESULTS: A total of 40 studies with 287 transplant patients with metastatic RMS (age range 0 to 32 years) were included in the assessment. We identified 3 non-randomized controlled trials. The 3-year overall survival ranged from 22% to 53% in the transplant groups vs. 18% to 55% in the control groups. Meta-analysis on overall survival in controlled trials showed no difference between treatments. Result of meta-analysis of pooled individual survival data of case series and case reports, and results from uncontrolled studies with aggregate data were in the range of those from controlled data. The risk of bias was high in all studies due to methodological flaws. CONCLUSIONS: HDCT followed by autologous HSCT in patients with RMS remains an experimental treatment. At present, it does not appear justifiable to use this treatment except in appropriately designed controlled trials

Update on the Combined Analysis of Muon Measurements from Nine Air Shower Experiments

Over the last two decades, various experiments have measured muon densities in extensive air showers over several orders of magnitude in primary energy. While some experiments observed differences in the muon densities between simulated and experimentally measured air showers, others reported no discrepancies. We will present an update of the meta-analysis of muon measurements from nine air shower experiments, covering shower energies between a few PeV and tens of EeV and muon threshold energies from a few 100 MeV to about 10GeV. In order to compare measurements from different experiments, their energy scale was cross-calibrated and the experimental data has been compared using a universal reference scale based on air shower simulations. Above 10 PeV, we find a muon excess with respect to simulations for all hadronic interaction models, which is increasing with shower energy. For EPOS-LHC and QGSJet-II.04 the significance of the slope of the increase is analyzed in detail under different assumptions of the individual experimental uncertainties

Search for Spatial Correlations of Neutrinos with Ultra-high-energy Cosmic Rays

For several decades, the origin of ultra-high-energy cosmic rays (UHECRs) has been an unsolved question of high-energy astrophysics. One approach for solving this puzzle is to correlate UHECRs with high-energy neutrinos, since neutrinos are a direct probe of hadronic interactions of cosmic rays and are not deflected by magnetic fields. In this paper, we present three different approaches for correlating the arrival directions of neutrinos with the arrival directions of UHECRs. The neutrino data are provided by the IceCube Neutrino Observatory and ANTARES, while the UHECR data with energies above ∼50 EeV are provided by the Pierre Auger Observatory and the Telescope Array. All experiments provide increased statistics and improved reconstructions with respect to our previous results reported in 2015. The first analysis uses a high-statistics neutrino sample optimized for point-source searches to search for excesses of neutrino clustering in the vicinity of UHECR directions. The second analysis searches for an excess of UHECRs in the direction of the highest-energy neutrinos. The third analysis searches for an excess of pairs of UHECRs and highest-energy neutrinos on different angular scales. None of the analyses have found a significant excess, and previously reported overfluctuations are reduced in significance. Based on these results, we further constrain the neutrino flux spatially correlated with UHECRs