14,801 research outputs found
Methylation Status of Imprinted Genes and Repetitive Elements in Sperm DNA from Infertile Males
Stochastic, environmentally and/or genetically induced disturbances in the genome-wide epigenetic reprogramming processes during male germ-cell development may contribute to male infertility. To test this hypothesis, we have studied the methylation levels of 2 paternally (H19 and GTL2) and 5 maternally methylated (LIT1, MEST, NESPAS, PEG3, and SNRPN) imprinted genes, as well as of ALU and LINE1 repetitive elements in 141 sperm samples, which were used for assisted reproductive technologies (ART), including 106 couples with strictly male-factor or combined male and female infertility and 28 couples with strictly female-factor infertility. Aberrant methylation imprints showed a significant association with abnormal semen parameters, but did not seem to influence ART outcome. Repeat methylation also differed significantly between sperm samples from infertile and presumably fertile males. However, in contrast to imprinted genes, ALU methylation had a significant impact on pregnancy and live-birth rate in couples with male-factor or combined infertility. ALU methylation was significantly high-er in sperm samples leading to pregnancy and live-birth than in those that did not. Sperm samples leading to abortions showed significantly lower ALU methylation levels than those leading to the birth of a baby. Copyright (C) 2011 S. Karger AG, Base
Systematic Errors in the Estimation of Black Hole Masses by Reverberation Mapping
The mass of the central black hole in many active galactic nuclei has been
estimated on the basis of the assumption that the dynamics of the broad
emission line gas are dominated by the gravity of the black hole. The most
commonly-employed method is to estimate a characteristic size-scale from
reverberation mapping experiments and combine it with a characteristic velocity
taken from the line profiles; the inferred mass is then estimated by . We critically discuss the evidence supporting the assumption of
gravitational dynamics and find that the arguments are still inconclusive. We
then explore the range of possible systematic error if the assumption of
gravitational dynamics is granted. Inclination relative to a flattened system
may cause a systematic underestimate of the central mass by a factor , where is the aspect ratio of the flattening. The coupled
effects of a broad radial emissivity distribution, an unknown angular radiation
pattern of line emission, and sub-optimal sampling in the reverberation
experiment can cause additional systematic errors as large as a factor of 3 or
more in either direction.Comment: 19 pages, 4 figures, AASLaTeX, accepted by Ap
Effect of Alternative Wheat and Feed Grain Prices on Optimum Farm Plans and Income, Faulk and Potter Counties, South Dakota
The general objectives of the research undertaken in South Dakota were: (1) To provide economic data needed by farmers to make profitable adjustments in their farming systems and production practices, and (2) To develop a research background for evaluating government farm programs under varying assumptions
The Virginia Conspiracy Statute Part II: Liability of Conspirators for Compelling Another to Act Against His Will or Constraining Another from Doing a Lawful Act
Effect of Alternative Wheat and Feed Grain Prices on Optimum Farm Plans and Income, North Central South Dakota
The purpose of this report is to present some results of a cooperative research project between the South Dakota Agricultural Experiment Station and the Farm Production Economics Division, Economic Research Service, U. S. Department of Agriculture. This research contributes to a larger project-GP-5, Economic Problems in the Production and Marketing of Great Plains Wheat. The general objectives of the research undertaken in South Dakota were: (1) To provide economic data needed by farmers to make profitable adjustments in their farming systems and production practices, and (2) To develop a research background for evaluating government farm programs under varying assumptions
Weak localization and spin splitting in inversion layers on p-type InAs
We report on the magnetoconductivity of quasi two-dimensional electron
systems in inversion layers on p-type InAs single crystals. In low magnetic
fields pronounced features of weak localization and antilocalization are
observed. They are almost perfectly described by the theory of Iordanskii,
Lyanda-Geller and Pikus. This allows us to determine the spin splitting and the
Rashba parameter of the ground electric subband as a function of the electron
density.Comment: Accepted for publication in Phys. Rev. B, 4 page
The five-minute oscillations: What's left to be done
Current observational methods for studying these oscillations at large horizontal wavenumbers are discussed in detail and several two dimensional power spectra obtained with a CID camera on the main spectrograph of the McMath telescope at Kitt Peak National Observatory are described. The best-resolved observations of the p-mode obtained at chromospheric elevations are also presented. Recent progress in studies of the p-modes at low wavenumbers with full-disk velocity detection schemes is summarized. These full-disk observations of radial and low-degree non-radial modes were shown to place severe constraints on the theoretical calculation of solar interior structure. Progress in making fully-consistent solar models which fit both the high- and low-wave number observations is described. Finally, the observational and theoretical improvements that are necessary for further progress in solar seismology are summarized
Elasticity of highly cross-linked random networks
Starting from a microscopic model of randomly cross-linked particles with
quenched disorder, we calculate the Laudau-Wilson free energy S for arbitrary
cross-link densities. Considering pure shear deformations, S takes the form of
the elastic energy of an isotropic amorphous solid state, from which the shear
modulus can be identified. It is found to be an universal quantity, not
depending on any microscopic length-scales of the model.Comment: 6 pages, 5 figure
Open Space – a collaborative process for facilitating Tourism IT partnerships
The success of IT projects depends on the success of the partnerships on which they are based. However past research by the author has identified a significant rate of failure in these partnerships, predominantly due to an overly technical mindset, leading to the question: “how do we ensure that, as technological solutions are implemented within tourism, due consideration is given to human-centred issues?” The tourism partnership literature is explored for additional insights revealing that issues connected with power, participation and normative positions play a major role. The method, Open Space, is investigated for its ability to engage stakeholders in free and open debate. This paper reports on a one-day Open Space event sponsored by two major intermediaries in the UK travel industry who wanted to consult their business partners. Both the running of the event and its results reveal how Open Space has the potential to address some of the weaknesses associated with tourism partnerships
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