The 1723 AD violent Strombolian and phreatomagatic eruption at Irazu volcano (Costa Rica)

The largest of the recorded historic eruptions at Irazú volcano began on February 16, 1723 and lasted until at least December 11. We here critically examine deposits of this eruption exposed on the summit of Irazú. Our reconstruction of the eruption is based on the unique chronicle of the Spanish governor Diego de la Haya. The eruption began with a < 10 cm thick surge deposit of phreatic origin showing block sag structures. The deposit is overlain by 6 m-thick coarse-grained basaltic andesitic non-graded juvenile fallout tephra consisting of highly vesicular (22-59 vol.%) bombs and lapilli with minor hydrothermally altered lapilli (1-7 vol.%) and rare light colored andesitic vesicular lapilli (< 1%). These fallout deposits are interpreted as strombolian, possible generated during a short-lived scoria cone at the end of February 1723, dominate volumetrically in the proximal facies. Overlying <1.2 m thick phreatomagmatic deposits of fi nely laminated lapilli-bearing gray ash (fallout and surge deposits) some with contorted bedding and sag structures, are in turn overlain by a 1.2 m thick bed of ash matrix-rich bomb/block deposit. The 1723 eruption was accompanied by shallow volcano-tectonic earthquakes (Modifi ed Mercalli scale Intensity MMI VI-VII, magnitude ML ~5.5) that possibly facilitated magma/water interaction. Phenocrysts in the basaltic andesite (~53-55 wt.% SiO2) bombs comprise plagioclase (6.1-21.6 vol.%, An52-35), clinopyroxene (2.5-10 vol.%), orthopyroxene (0.7-2 vol.%), olivine (0.1-2.2 vol.%; Fo76-88) and Fe/Ti-oxides (0.1-1%), in a groundmass (66.5-90.3 vol. %), dominated by plagioclase (An69-54), clinopyroxene and opaques in brown and black glass with the same range of chemical composition (SiO2= 57-64 wt.%). Rare white pumiceous lapilli in the scoria deposits are high-K, hornblende andesite (SiO2: 58-60 wt.%), geochemically unrelated to the scoria deposits. Thus, two different magmas co-existing in the magma chamber were mingled shortly before, and during, the eruption, suggesting that the eruption was triggered by magma mingling between hornblende andesite and basaltic andesite magma

Identification of the Amino Acids 300–600 of IRS-2 as 14-3-3 Binding Region with the Importance of IGF-1/Insulin-Regulated Phosphorylation of Ser-573

Phosphorylation of insulin receptor substrate (IRS)-2 on tyrosine residues is a key event in IGF-1/insulin signaling and leads to activation of the PI 3-kinase and the Ras/MAPK pathway. Furthermore, phosphorylated serine/threonine residues on IRS-2 can induce 14-3-3 binding. In this study we searched IRS-2 for novel phosphorylation sites and investigated the interaction between IRS-2 and 14-3-3. Mass spectrometry identified a total of 24 serine/threonine residues on IRS-2 with 12 sites unique for IRS-2 while the other residues are conserved in IRS-1 and IRS-2. IGF-1 stimulation led to increased binding of 14-3-3 to IRS-2 in transfected HEK293 cells and this binding was prevented by inhibition of the PI 3-kinase pathway and an Akt/PKB inhibitor. Insulin-stimulated interaction between endogenous IRS-2 and 14-3-3 was observed in rat hepatoma cells and in mice liver after an acute insulin stimulus and refeeding. Using different IRS-2 fragments enabled localization of the IGF-1-dependent 14-3-3 binding region spanning amino acids 300–600. The 24 identified residues on IRS-2 included several 14-3-3 binding candidates in the region 300–600. Single alanine mutants of these candidates led to the identification of serine 573 as 14-3-3 binding site. A phospho-site specific antibody was generated to further characterize serine 573. IGF-1-dependent phosphorylation of serine 573 was reduced by inhibition of PI 3-kinase and Akt/PKB. A negative role of this phosphorylation site was implicated by the alanine mutant of serine 573 which led to enhanced phosphorylation of Akt/PKB in an IGF-1 time course experiment. To conclude, our data suggest a physiologically relevant role for IGF-1/insulin-dependent 14-3-3 binding to IRS-2 involving serine 573

Oscillation frequencies and mode lifetimes in alpha Centauri A

We analyse our recently-published velocity measurements of alpha Cen A (Butler et al. 2004). After adjusting the weights on a night-by-night basis in order to optimize the window function to minimize sidelobes, we extract 42 oscillation frequencies with l=0 to 3 and measure the large and small frequency separations. We give fitted relations to these frequencies that can be compared with theoretical models and conclude that the observed scatter about these fits is due to the finite lifetimes of the oscillation modes. We estimate the mode lifetimes to be 1-2 d, substantially shorter than in the Sun.Comment: Accepted by Ap

Preclinical animal acute toxicity studies of new developed MRI contrast agent based on gadolinium

Acute toxicity test of new developed MRI contrast agent based on disodium salt of gadopentetic acid complex were carried out on Mus musculus and Sprague Dawley rats according to guidelines of preclinical studies [1]. Groups of six animals each were selected for experiment. Death and clinical symptoms of animals were recorded during 14 days. As a result the maximum tolerated dose (MTD) for female mice is 2.8 mМ/kg of body weight, male mice - 1.4 mМ/kg, female rats - 2.8 mМ/kg, male rats - 5.6 mМ/kg of body weight. No Observed Adverse Effect Dose (NOAEL) for female mice is 1.4 mМ/kg, male mice - 0.7 mМ/kg, male and female rats - 0.7 mМ/kg. According to experimental data new developed MRI contrast agent based on Gd-DTPA complex is low-toxic

Comparison of continuous and intermittent renal replacement therapy for acute renal failure

Background. Mortality rates of critically ill patients with acute renal failure (ARF) requiring renal replacement therapy (RRT) are high. Intermittent and continuous RRT are available for these patients on the intensive care units (ICUs). It is unknown which technique is superior with respect to patient outcome. Methods. We randomized 125 patients to treatment with either continuous venovenous haemodiafiltration (CVVHDF) or intermittent haemodialysis (IHD) from a total of 191 patients with ARF in a tertiary-care university hospital ICU. The primary end-point was ICU and in-hospital mortality, while recovery of renal function and hospital length of stay were secondary end-points. Results. During 30 months, no patient escaped randomization for medical reasons. Sixty-six patients were not randomized for non-medical reasons. Of the 125 randomized patients, 70 were treated with CVVHDF and 55 with IHD. The two groups were comparable at the start of RRT with respect to age (62±15 vs 62±15 years, CVVHDF vs IHD), gender (66 vs 73% male sex), number of failed organ systems (2.4±1.5 vs 2.5±1.6), Simplified Acute Physiology Scores (57±17 vs 58±23), septicaemia (43 vs 51%), shock (59 vs 58%) or previous surgery (53 vs 45%). Mortality rates in the hospital (47 vs 51%, CVVHDF vs IHD, P = 0.72) or in the ICU (34 vs 38%, P = 0.71) were independent of the technique of RRT applied. Hospital length of stay in the survivors was comparable in patients on CVVHDF [median (range) 20 (6-71) days, n = 36] and in those on IHD [30 (2-89) days, n = 27, P = 0.25]. The duration of RRT required was the same in both groups. Conclusion. The present investigation provides no evidence for a survival benefit of continuous vs intermittent RRT in ICU patients with AR

Near surface nutrient and phytoplankton distribution in the Drake Passage during early December

Nutrient concentrations and phytoplankton species composition in near surface samples were studied along a S-N gradient in the Drake Passage, in early December 1984. Nitrate concentrations were much lower than usually previously reported from circum-Antarctic waters. Comparison of dissolved nutrient concentrations with growth requirements of Antarctic plankton algae suggests potential limitation of at least some species by nitrate or silicate. The taxonomic composition of the phytoplankton in our samples seemed to be partially controlled by competition for limiting nutrients

Knowledge practices in design: The role of visual representations as 'epistemic objects'

We use a detailed study of the knowledge work around visual representations to draw attention to the multidimensional nature of `objects'. Objects are variously described in the literatures as relatively stable or in flux; as abstract or concrete; and as used within or across practices. We clarify these dimensions, drawing on and extending the literature on boundary objects, and connecting it with work on epistemic and technical objects. In particular, we highlight the epistemic role of objects, using our observations of knowledge work on an architectural design project to show how, in this setting, visual representations are characterized by a `lack' or incompleteness that precipitates unfolding. The conceptual design of a building involves a wide range of technical, social and aesthetic forms of knowledge that need to be developed and aligned. We explore how visual representations are used, and how these are meaningful to different stakeholders, eliciting their distinct contributions. As the project evolves and the drawings change, new issues and needs for knowledge work arise. These objects have an `unfolding ontology' and are constantly in flux, rather than fully formed. We discuss the implications for wider understandings of objects in organizations and for how knowledge work is achieved in practice

The violent past of Cygnus X-2

Cygnus X-2 appears to be the descendant of an intermediate-mass X-ray binary (IMXB). Using Mazzitelli's (1989) stellar code we compute detailed evolutionary sequences for the system and find that its prehistory is sensitive to stellar input parameters, in particular the amount of core overshooting during the main-sequence phase. With standard assumptions for convective overshooting a case B mass transfer starting with a 3.5 M_sun donor star is the most likely evolutionary solution for Cygnus X-2. This makes the currently observed state rather short-lived, of order 3 Myr, and requires a formation rate > 1e-7 - 1e-6 per yr of such systems in the Galaxy. Our calculations show that neutron star IMXBs with initially more massive donors (> 4 M_sun) encounter a delayed dynamical instability; they are unlikely to survive this rapid mass transfer phase. We determine limits for the age and initial parameters of Cygnus X-2 and calculate possible dynamical orbits of the system in a realistic Galactic potential, given its observed radial velocity. We find trajectories which are consistent with a progenitor binary on a circular orbit in the Galactic plane inside the solar circle that received a kick velocity < 200 km/s at the birth of the neutron star. The simulations suggests that about 7% of IMXBs receiving an arbitrary kick velocity from a standard kick velocity spectrum would end up in an orbit similar to Cygnus X-2, while about 10% of them reach yet larger Galactocentric distances.Comment: 9 pages, 12 figures, accepted for publication in MNRA