6 research outputs found

    A Parent-Teacher View of Teens Behaviors in Nuclear and Joint Family Systems in Pakistan

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    This research work tries to unveil the changing teen’s behaviors in nuclear and joint family systems in Pakistan. Pakistan enjoys the social values of joint families; and, where grandparents are very important constituent of the family, the family structure is an important component in shaping the teens behaviors. Therefore, this paper focuses the sample of parents and teachers of the teens in the postmodern urban society and tried to better point out the eminent changes in the attitudes and behaviors of teens. This study follows a qualitative approach of research that pursues a phenomenological inquiry describing lived experience of the respondents regarding teen’s behavior in Pakistan

    Role of Strategic Thinking in Corporate Identity

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    In this paper, an attempt has been made to unveil how strategic thinking contributes to corporate identity and survival. The instrument used to collect the data was a questionnaire which included a scale on creativity, pragmatic opportunism and intellectual informatism. The sample included the middle and top management of the telecom organizations in Pakistan. The questionnaires were distributed to 125 respondents and an 80% response was received. Results showed that strategic thinking has a fairly positive effect on corporate identity (CI). Among the creativity, intellectual informatism and pragmatic opportunism and when regressed with CI, pragmatic opportunism has the strongest effect on CI; creativity has a fairly positive impact on CI, whereas, intellectual informatism does not show significant impact on CI. Hopefully, this study will be informative for management about learning how they can use the available yet unfound opportunities and information within their creativity to build and maintain a good corporate identity

    Biallelic variants in CHST3 cause Spondyloepiphyseal dysplasia with joint dislocations in three Pakistani kindreds

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    Background Skeletal dysplasia is a heterogeneous group of disorders. Spondyloepiphyseal dysplasias comprise one subgroup. Deficiency of carbohydrate sulfotransferase 3 has been reported in a small number of patients with recessively inherited spondyloepiphyseal dysplasia with joint dislocation, short stature and scoliosis. We report here molecular and clinical findings of affected individuals in three consanguineous Pakistani families. Affected individuals in all three families had a uniform phenotype including severe short stature, multiple dislocated joints, progressive scoliosis and facial dysmorphism. Methods Clinical evaluation was done for three unrelated families. Radiological survey of bones was completed for patients from two of the families. Whole exome sequencing index patients from each family was performed followed by Sanger sequencing for validation of segregation of identified variants in respective families. In-silico analysis for determining pathogenicity of identified variants and conservation was done. Results Whole-exome sequencing revealed biallelic variants c.590 T > C;p.(Leu197Pro), c.603C > A;p.(Tyr201Ter) and c.661C > T;p.(Arg221Cys) in CHST3 (NM_004273.5) in the three families with eight, five and two affected individuals, respectively. Contrary to previous reports, affected individuals in none of the families exhibited a hearing loss. Conclusion We describe genotypic and phenotypic findings of three unrelated families with spondyloepiphyseal dysplasia. Our study confirms phenotypic variability and adds to the genotypic spectrum of spondyloepiphyseal dysplasia.Peer reviewe

    Significance of factors influencing online knowledge sharing: A study of higher education in Pakistan

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    Considering the importance of knowledge sharing in personal and professional life, this study focuses on behavior of knowledge sharing in online world. Henceforth, it explores the effect of different individual aspects like personality traits, engagement in online social networking sites and online community of practices on the online knowledge sharing behavior. In order to attain the goal of measuring the relationships, this study attempted a simultaneous multiple regression analysis technique to check their effect on online knowledge sharing behavior. One of the important and major contributions of this study is that the engagement of individuals in online social networking sites and online community of practices plays a very vital role in their online knowledge sharing behaviors in Pakistan. These findings are significant since they provide a better insight to the behavior of students when it comes to online knowledge sharing as a result of online social interaction. This study can find many utilities regarding the course contents and online study plans in educational institutes and personnel screening of human resource in commercial organizations

    Role of demographic diversity in online knowledge sharing

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    Knowledge sharing is not only the requirement of professional lives but it has proved its importance in daily lives as well. This study particularly addresses the behavior of knowledge sharing in online world. Therefore, this study explores the influence of demographic factors on the online knowledge sharing behavior in the sample of 319. In order to check the possible differences in the means of different demographic factor groups, this study applied independent sample t-test and one way analysis of variance (ANOVA). These findings are significant since they provide a better insight to the indifferent role of demographic diversity of students when it comes to online knowledge sharing as a result of online social interaction. This study can find many utilities regarding the course contents and online study plans in educational institutes and personnel screening of human resource in organizations

    Oral cholera vaccines; current perspective and future need; towards the development of novel DNA vaccine for Vibrio species

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    About one-third of the countries in the world are on the verge of a cholera outbreak placing over a billion individuals at risk. Water sanitation and health (WASH) programs together with vaccination are preventive measures to eradicate cholera by 2030. While WASH takes a long time to successfully implement, vaccinations can reduce the cholera burden. 2030 is in less than a decade and yet the current WHO prequalified oral cholera vaccines (OCVs) failed to provide sufficient protective immunity to infants – the most affected age group in cholera outbreaks and cholera endemic regions, a shorter immunity in older children and adults, the requirement of multiple doses, and cold-chain for transport and storage are some of the limitations of OCVs and WHO recommends further research to provide better vaccines. DNA vaccine approach could be a potential approach in the future of cholera vaccines, providing ease of vaccine design and hence reducing production time, it is safer and cheaper, stable at room temperature, and can induce both humoral and cellular immune responses. Therefore, this can be a better alternative to the over-dependence on the first and second generations of vaccines
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