2,019 research outputs found
Responsiveness of the International Classification of Functioning, Disability and Health (ICF) Core Set for rheumatoid arthritis
Background: The comprehensive International
Classification of Functioning, Disability and Health (ICF)
Core Set for rheumatoid arthritis (RA) is a selection of 96
categories from the ICF, representing relevant aspects in
the functioning of patients with RA.
Objectives: To study the responsiveness of the ICF Core
Set for RA in rheumatological practice.
Methods: A total of 46 patients with RA (72% women,
mean (SD) age 53.6 (12.6) years, disease duration 6.3
(8.0) years) were interviewed at baseline and again after
6 months treatment with a disease-modifying antirheumatic
drug (DMARD), applying the ICF Core Set for RA
with qualifiers for problems on a modified three-point
scale (no problem, mild/moderate, severe/complete).
Patient-reported outcomes included Modified Health
Assessment Questionnaire (MHAQ) and Short-Form 36
(SF-36) health survey, and disease activity was calculated.
Responsiveness was measured as change in
qualifiers in ICF categories, and was also compared with
change in patient-reported outcomes.
Results: After 6 months of DMARD treatment,
improvement by at least one qualifier was seen in 20% of
patients (averaged across all ICF categories), 71%
experienced no change and 9% experienced worsening
symptoms. Findings were similar across the different
aspects of functioning. Mainly moderate effect sizes were
seen for 6-month changes in the ICF Core Set for RA,
especially in patients with improved health status, with
similar effect size for disease activity. The components in
the ICF Core Set for RA were only weakly associated with
patient-reported outcomes and disease activity.
Conclusions: The ICF Core Set for RA demonstrated
moderate responsiveness in this real-life setting of
patients where minor changes occurred during treatment
with DMARDs
The relationship between data of gastric tonometry by determination of polymorphonuclear leukocytes (PMNs, i.e., myeloperoxidase activity) and gut mucosal hypoperfusion in elective cardiac surgical patients
L'estat actual de les Biblioteques del CSIC a Catalunya : objectius aconseguits i mancances
S'analitza l'estat actual de les biblioteques del Consell Superior d'Investigacions Científiques a Catalunya, en tant que pertanyents a la Xarxa de Biblioteques del CSIC, en particular la seva dependència de les comunicacions, els seus aspectes cooperatius, la informatització dels seus catàlegs, l'increment dels seus serveis, i la seva incorporació a les noves tecnologies de la informació. S'exposa la futura estructura de la Xarxa.Se analiza el estado actual de las bibliotecas del Consejo Superior de Investigaciones Científicas en Cataluña considerando que pertenecen a la Red de Bibliotecas del CSIC, en particular su dependencia de las comunicaciones, aspectos cooperativos, informatización de sus catálogos, incremento de sus servicios y la incorporación de nuevas tecnologías de la información. Se expone la futura estructura de la Red
Dynamics of Electron Localization in Warm vs. Cold Water Clusters
The process of electron localization on a cluster of 32 water molecules at 20, 50, and 300~K is unraveled using ab initio molecular dynamics simulations. In warm, liquid clusters, the excess electron relaxes from an initial diffuse and weakly bound structure to an equilibrated, strongly bound species within 1.5 ps. In contrast, on cold, glassy clusters the relaxation processes is not completed
and the electron becomes trapped in a metastable surface state with an intermediate binding energy. These results question the validity of extrapolations of the properties of solvated electrons from cold clusters of increasing size to the liquid bulk
Quadricuspid pulmonary valve complicated with aneurysm of pulmonary trunk diagnosed with ECG-gated computed tomography
Quadricuspid pulmonary valve (QPV) is an uncommon congenital defect reported
in the general population with a frequency of up to 0.25%. The defect
usually does not cause severe clinical complications and its presence frequently
remains clinically silent. Moreover, there are several difficulties in visualization
of pulmonary valve using basic diagnostic modalities such as echocardiography.
Therefore, in the majority of cases, QPV is detected accidentally during cardiac
procedures or post mortem.
The authors present a case of QPV complicated with aneurysm of the pulmonary
trunk, diagnosed with computed tomography in 70-year-old woman.
Although the patient had undergone transthoracic echocardiography examinations
several times in the past, only computed tomography allowed the detection
of the anomalous valve. In addition, the examination confirmed aneurysm
of the pulmonary trunk.
To the best of our knowledge, this is the first case of QPV diagnosed in vivo
with computed tomography
The relationship between renal function and renal urodilatin excretion immediately after cardiac surgery
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