Nietzsche and Realism: the Concept of Will to Power in Nietzsche and Realist Paradigm

DergiPark: 530601trakyasobedBuçalışmada, Nietzsche’nin felsefesinde güç istenci düşüncesi, uluslararasıilişkiler disiplininin temel tartışmaları özelinde, yeni paradigmayla ilişkiliolarak tartışılmıştır. Bu tartışmalar daha çok E.H. Carr, Morgenthau, Waltz gibiisimlere referansla realist paradigma çerçevesinde ele alınacaktır. Güç istencikavramı uluslararası ilişkiler perspektifinden değerlendirilecek, uluslararasıilişkiler açısından büyük kırılma noktalarının tespit edilmesinde güçistencinin belirleyici rolü saptanacaktır. Nietzsche’nin güç istencidüşüncesiyle ortaya koyduğu yeni paradigmanın, çatışmaya ve sürekli çıkarmücadelesine dayalı perspektifi multidisipliner bir bakış açısıyla birleştirmeiddiası değerlendirilecektir. Çalışmanın temel hedefi, uluslararası ilişkilerdisiplinindeki tartışmalara, özellikle realist paradigma çerçevesinde, bualanda sınırlı düzeyde tartışılan Nietzsche’nin siyaset felsefesi üzerindenyeni bir açılım getirmek ve Nietzsche’nin güç istenci düşüncesiyle, realizmingüç kavramı arasındaki ortak noktaları değerlendirmektir. In this study, the will to power in Nietzsche's philosophy has beendebated in relation to the new paradigm, in particular, in the basic argumentsof the discipline of international relations. This study will approach thesediscussions mostly in reference to names such as E.H. Carr, Morgenthau, Waltz,etc., in the context of realist paradigm. The concept of “will to power” willbe evaluated from the perspective of international relations, and thedistinctive role of the “will to power” in terms of breaking points will bedetermined. The claim that the new paradigm that Nietzsche puts forward withthe idea of the will to power combines the perspective based on conflict andongoing conflict of interest with a multidisciplinary point of view will bediscussed. The main objective of the study is to bring about a new breakthroughto the discussions in international relations discipline specifically withinthe frame of realist paradigm, through Nietzsche's political philosophy, whichis rarely discussed in this area, and discuss the common points between theconcept of power in realism and Nietzsche's idea of will to power.

Contrubition of Laparoscopic Level Determination on Hirschsprung Disease Diagnosis and Management

Aim:Laparoscopic-assisted transanal pull-through (LATP) is a procedure that has gained increasing popularity in the management of Hirschsprung’s disease. The purpose of this study was to compare outcomes of patients treated with LATP and transanal pull-through (TPT).Methods:Records of 45 patients with Hirschsprung’s disease who underwent surgery between 2006 and 2017 were retrospectively evaluated.Results:LATP was performed in 16 patients [13 male (81%), three female (19%)]. The median age of the patients was four months (7 days-84 months). Twenty nine patients [21 male (72.4%), eight female (27.6%)] underwent TPT. The median age of the patients was 11 months (10 days-90 months). The mean time to start feeding in LATP and TPT groups was two days (one-three days) and 2.6 days, respectively (p=0.074). The mean operative time was 2.6 hours in the LATP group (two-four hours) and 2.7 hours in the TPT group (p=0.971). The mean length of hospital stay in for LATP and TPT groups was 4.8 days (two-nine days) and six days (3-14 days), respectively (p=0.305).Conclusion:The advantages of LATP include multiple sample collection from several segments of the colonn at the same time as well as shorter time to frozen section diagnosis. In addition, the possibility of intraabdominal dissection allows transanal surgery to be faster and more effective

EFFECT OF GASTRONOMY TOURISM TO PROVINCE TOURISM: EXAMPLE OF CANAKKALE(Gastronomi Turizminin İl Turizmine Etkisi Çanakkale Örneği)

Our country has hosted various civilizations and is situated in a richgeography, where many cultures live together. This cultural diversity hascontributed to the formation of different traditions in our food culture indifferent regions.Canakkale is a special location with its unique position, four seasonsclimate, rich natural beauties and different civilizations' historical and culturalvalues. Divided by the Bosporus bearing the same name and having lands inboth Asia and Europe, Canakkale has the potential to become a rich touristcenter. Canakkale attracts many visitors with its historical and natural beauty.Canakkale hosted many cultures from past to present. Canakkale has agastronomy potential including all the properties for a tourist who is lookingfor different colors and flavors.In this study, the analysis of Canakkale tourism, Canakkale gastronomytourism potential and the place and importance of wine in gastronomy tourismare emphasized. Also, food and beverages forthcoming with gastronomytourism on the menus are determined by field and literature scans.This study aims to measure the impact of Canakkale's local food cultureas a touristic product to Canakkale tourism with its high gastronomy potential.By using face to face interview technique, a qualitative research method isapplied in the study. Interviews have been made with tourism policy makersand service providers in Canakkale. The data obtained with semi-structuredquestionnaire are analyzed with NVIVO 10 program and based on findingsrecommendations and models were developed.</p

Sagittale skelettale korrektur mittels symphysealen miniplattenverankerungssystemen

WOS: 000455930500002PubMed ID: 30413832ObjectivesAim of this study is to evaluate success rates and complications related with symphyseal miniplate anchorage systems used for treatment of Class2 and Class3 deformities.MethodsAtotal of 58miniplates applied to 29growing patients were evaluated. The first group comprised 24symphyseal miniplates applied to 12patients and Forsus Fatigue Resistant Devices were attached to the head of the miniplates for mandibular advancement. The second group consisted of 34symphyseal miniplates applied to 17patients and intermaxillary elastics were applied between acrylic appliances placed on the maxillary dental arch and the symphyseal miniplates for maxillary protraction. Success rate and complications of the symphyseal plate-screw anchorage system were evaluated.ResultsThe overall success rate of symphseal miniplates was 87.9%. Six miniplates showed severe mobility and 2miniplates broke during orthodontic treatment. Infection, miniplate mobility and mucosal hypertrophy were statistically different between the two groups.ConclusionsSymphyseal miniplates were generally used as successful anchorage units in most patients. Infection, mobility, and mucosal hypertrophy occurred more frequently in Class2 deformity correction. However, the success rates regarding the two treatment modalities were comparable.Ziele Ziel der vorliegenden Studie ist es, Erfolgsraten und Komplikationen im Zusammenhang mit symphysealen Miniplattenverankerungssystemen zur Behandlung von Klasse-II- und -III-Anomalien zu bewerten. Methoden Ausgewertet wurden insgesamt 58 Miniplatten, die bei 29 Patienten im Wachstum inseriert wurden. In der ersten Gruppe wurden 24 symphyseale Miniplatten bei 12 Patienten inseriert. Zur Korrektur der Unterkieferrücklage wurden Forsus-Apparaturen an den Miniplatten verankert. In der zweiten Gruppe wurden 34 symphyseale Miniplatten bei 17 Patienten inseriert. Zur Protraktion des Oberkiefers wurden intermaxilläre Elastics verwendet, die zwischen Acrylgeräten im Oberkiefer und den symphysealen Miniplatten eingehängt wurden. Untersucht wurden Erfolgs- und Komplikationsraten des symphysealen Platten-Schrauben-Verankerungssystems. Ergebnisse Die Gesamterfolgsrate der symphsealen Miniplatten betrug 87,9%. Bei 6 Miniplatten zeigte sich eine hohe Mobilität, 2 frakturierten während der kieferorthopädischen Behandlung. Das Auftreten von Infektion, Miniplattenmobilität und Schleimhauthypertrophie war zwischen den beiden Gruppen statistisch unterschiedlich. Schlussfolgerungen Symphyseale Miniplatten wurden in der Regel bei den meisten Patienten als erfolgreiche Verankerungseinheiten eingesetzt. Infektion, Mobilität und Schleimhauthypertrophie traten häufiger bei Klasse-2-Korrekturen auf, die Ergebnisse beider Behandlungsmethoden unterschieden sich jedoch nur geringfügig

Preoperative therapeutic plasmapheresis in thyrotoxic patients who did not effectively treated with antithyroid drugs, iodine and corticosteroid

Introduction: Preoperative treatment options in thyrotoxic patients are antithyroid drugs, potassium iodide, beta blockers and corticosteroids. Sometimes these treatment regimens have not been so successful for the patients to make them ready for the operation. So we thought that plasmapheresis (PP) could be an alternative to these treatments. Methods: Two thyrotoxic patients with Graves' disease and one patient with toxic multinodular goiter were included in the study. All patients were candidates to surgical operation due to the contraindication of other medical treatment choices. On admission, all patients had severe uncontrolled hyperthyroidism. In order to prepare our patients to operation, all the patients were given beta blockers and inorganic potassium iodide and corticosteroid at first but disease control could not be achieved in terms of thyrotoxicosis. So PP was performed at an average of 3 to 5 sessions. Results: After PP, all patients' thyroid hormone concentrations were significantly reduced. One patient had an anaphylactic reaction during 3th session of PP. Total thyroidectomy was performed to all patients without any complications. Conclusions: We concluded that PP could be used as an alternative therapeutic option in the preoperative management of severe thyrotoxic patients. © 2010 Düzce Medical Journal

Preoperative Therapeutic Plasmapheresis In Thyrotoxic Patients Who Did Not Effectively Treated With Antithyroid Drugs, Iodine And Corticosteroid

Introduction: Preoperative treatment options in thyrotoxic patients are antithyroid drugs,potassium iodide, beta blockers and corticosteroids. Sometimes these treatment regimens havenot been so successful for the patients to make them ready for the operation. So we thought thatplasmapheresis (PP) could be an alternative to these treatments. Methods: Two thyrotoxic patients with Graves’ disease and one patient with toxic multinodulargoiter were included in the study. All patients were candidates to surgical operation due to thecontraindication of other medical treatment choices. On admission, all patients had severeuncontrolled hyperthyroidism. In order to prepare our patients to operation, all the patients weregiven beta blockers and inorganic potassium iodide and corticosteroid at first but disease controlcould not be achieved in terms of thyrotoxicosis. So PP was performed at an average of 3 to 5sessions. Results: After PP, all patients’ thyroid hormone concentrations were significantly reduced. Onepatient had an anaphylactic reaction during 3th session of PP. Total thyroidectomy wasperformed to all patients without any complications.Conclusions: We concluded that PP could be used as an alternative therapeutic option in thepreoperative management of severe thyrotoxic patients

Serum transforming growth factor-beta levels in patients with vitamin D deficiency

WOS: 000298148800028PubMed: 22153539Background: Transforming growth factor-beta 1 (TGF-beta 1) contributes to tissue repair by promoting tissue fibrosis, and elevations have been reported in patients with bone marrow fibrosis. The aim of this study was to evaluate the relationship between TGF-beta 1 levels and vitamin D deficiency. Methods: All patients presenting to the outpatient Endocrinology and Metabolic Diseases clinic between June and September of 2008 were approached, and consenting patients who were deemed suitable candidates were enrolled. Hematological parameters were measured, along with serum levels of total and ionized calcium, phosphorus, parathyroid hormone, iron, folic acid vitamin B12 levels, 25 OH vitamin D3 (25OHD(3)) and TGF-beta 1. Results: A total of 132 patients were included in the study. Patients were divided into 4 groups based on levels of 25OHD(3) [group 1 ( 30 ng/ml), 28 patients]. TGF-beta 1 levels were higher in patients in group 1 compared to the other groups. Transforming growth factor-beta levels correlated negatively with vitamin D3 and positively with leukocyte count, platelet count, of MCV and MCH. Multiple regression analyses revealed TGF-beta 1 levels to be associated with 25OHD(3) as well as with platelet count. Conclusions: Results of this study are suggestive of the presence of a significant relationship between TGF-beta and vitamin D deficiency. Increased TGF-beta 1 and platelet count may be an early indicator of bone marrow fibrosis in patients with vitamin D deficiency. Crown Copyright (C) 2011 Published by Elsevier B. V. on behalf of European Federation of Internal Medicine. All rights reserved

Comparison of Endoscopic and Microscopic Endonasal Transsphenoidal Surgery Approaches in Acromegalic Patients.

92nd Meeting and Expo of the Endocrine Society (ENDO 2010) -- JUN 19-22, 2010 -- San Diego, CAWOS: 000281989403267…Endocrine Societ

Clinical and radiological findings in macroprolactinemia

WOS: 000303584800021PubMed: 22187359Hyperprolactinemia is the most common abnormality of the hypothalamic-pituitary axis. The aim of this study was to investigate the clinical and radiological features of patients with macroprolactinemia. The study population consisted of patients with elevated serum prolactin (PRL) concentrations who presented to our Endocrinology outpatient clinic. Detection of macroprolactin (macroPRL) was performed using the polyethylene glycol precipitation method. Patients in which macroPRL made up more than 60% of total PRL levels were stratified into the macroPRL group, while the remaining patients were placed in the monomeric prolactin (monoPRL) group. A total of 337 patients were enrolled with a mean age of 33.8 +/- 10.8 (16-66) years and a male/female ratio of 29/308. Eighty-eight of the patients (26.1%) had an elevated macroPRL level. The mean age in the monoPRL group was higher than in the macroPRL group (35.0 +/- 10.1 vs. 30.7 +/- 9.8, P = 0.016). The mean PRL levels (ng/ml) in the macroPRL and monoPRL groups were similar (168.0 +/- 347.0 vs. 238.8 +/- 584.9, P = 0.239). Frequency of amenorrhea, infertility, irregular menses, gynecomastia, and erectile dysfunction were also similar in both groups. More patients in the macroPRL group were asymptomatic compared to the monoPRL group (30.2 vs. 12.0%, P = 0.006). Compared to the macroPRL group, the monoPRL group had a higher frequency of galactorrhea (39.2 vs. 57.1%, P = 0.04) and abnormal magnetic resonance imaging findings (65.3 vs. 81.1%, P = 0.02). Elevated macroPRL levels should be considered a pathological biochemical variant of hyperprolactinemia that may present with any of the conventional symptoms and radiological findings generally associated with elevated PRL levels