2 research outputs found
Chromosomal Alterations in Ulcerative Colitis-Related and Sporadic Colorectal Cancers by Comparative Genomic Hybridization
Both ulcerative colitis (UC)-related and sporadic colorectal cancers are thought to evolve through a multistep process of genomic instability, accumulation of genomic alterations and clonal expansion. This process may involve different genomic changes in UC-related cancers than in sporadic cancers due to the origin of UC-related cancers in an inflammatory field. This study was designed to define the specific genomic events in UC-related cancers. Comparative genomic hybridization (CGH) was performed on 32 UC-related and 42 stage-matched sporadic colorectal cancers. The mean number of chromosomal alterations per case was similar in the UC-related and sporadic tumor groups (8.6 in UC, 8.1 in sporadic). Frequently lost regions in both cancer groups were 18q (78% UC, 69% sporadic), 8p (53% UC, 50% sporadic), and 17p (44% UC, 57% sporadic). The three most frequent gains involved chromosomes 8q (63% UC, 45% sporadic), 20q (44% UC, 67% sporadic), and 13q (44% UC, 38% sporadic). Chromosome 5q was lost in 56% of UC-related but in only 26% of sporadic cancers. Losses of 17q and gains of 5p were also more frequent in UC-related cancers, whereas losses of 14q and gains of Xp were significantly less common in UC-related cancers than in sporadic tumors. There was a stage-related increase in chromosome 8 alterations in UC-related but not in sporadic cancers, while only sporadic tumors showed a stage progression for 5p loss, 17q gain, and 18q loss. Thus, differences in the frequency and timing of individual chromosomal alterations suggest that the genetic pathways in these two tumor groups are distinct from each other.