A Multisectoral Approach in Dengue Management in Seremban Malaysia: an Ecobiosocial Perspective

Background: Dengue has been established as a major public health issue in many parts of the world particularly those in the tropical regions. In Malaysia, the rising rate of dengue cases had remained uncurbed, alarming to both the public and the local authorities. Despite the existence of legislations and control activities, why does the number of dengue cases keep on increasing every year? The objective of this study was to assess the existing environmental and health policies/strategies towards sustainable prevention and control of dengue/DHF in Malaysia. In addition, it also aimed to review the eco-bio-social approach and its advantages in prevention and control of dengue. Subjects and Method: Series of in-depth interviews were conducted on 12 key- informants aged between 36-58 years old. They were selected based on their roles that were divided into three categories, i.e. (1) policy makers, (2) middle managers, and (3) implementers at the ground level. Each interview explored in detail, on the important domains which were the ecology, biology, and social factors. Each session took an average of 45 minutes to 1 hour. There were a total of 10 males and 2 females selected for the in-depth interview. Open-ended questions were asked and the interviews were voice recorded, after obtaining consent from the respondents. The interviews were terminated once data saturation was achieved. The qualitative data was analyzed using Atlas.ti software. Results: The three main themes that emerged and were identified to contribute to sustainable dengue control and prevention were (1) adequate implementation of existing health policy, (2) good integration and coordination between agencies, (3) commitment from political and community leaders. Local data showed that areas which did not have these important components became hot spots for dengue with high number of dengue cases. Conclusion: It is vital that the community and relevant authorities focus on these themes/domains that will significantly improve the chances of having sustainable denguecontrol and management program in their localities. Keywords: multisectoral approach, ecobiosocial, engue control, sustainable managemen

Pengaruh Peningkatan Lipofilisitas Pada Senyawa Analog Uk-3a Dalam Menghambat Pertumbuhan Sel Kanker P-388

Antibiotic UK-3A contains a 9-membered dilactone ring. It had been isolated as a minor component from the mycelium of 5trepyomyces sp. 51701.The antibiotic was hypothesized to be potential to inhibit the growth of leukemia cancer cell line of P388 and KB with ICso 38 and 20 Dg/mL, respectively. To understand the effect of lipophilicity increase of the analogues on their anticancer activities based on QSAR parameter (Log P) and binding energy to BcL-xL protein. To produce analogues of UK-3A, 3hydroxypicolinyl serine methyl ester (A) was synthesized from 3-hydroxypicolinic acid and L-serine methyl ester. The product was then esterified by pentanoic (1), hexanoic (2), heptanoic (3), and octanoic (4). The final products were confirmed with IHand 13C FT-NMR and FTIR spectra, and also MS spectra. Then they were tested against P388 Murine Leukemia cells. The result of bioassay showed lipophilicity increase of3hydroxypicolinyl serine methyl octhyl ester (PSMOE) correlated positively with their anticancer activity increase, withICso 15.4mg/mL against P388 cell lines

Survei Cepat terhadap Tikus dan Keong Perantara Schistosomiasis di Daerah Endemis, Dataran Tinggi Bada Kabupaten Poso, Sulawesi Tengah

Schistosomiasis merupakan penyakit terabaikan (neglected disease) yang ditemukan endemis di Sulawesi Tengah, yaitu di Dataran Tinggi Lindu, Napu dan Bada. Dataran tinggi Bada merupakan daerah endemis schistosomiasis yang baru ditemukan pada tahun 2008. Survei cepat ini bertujuan untuk mendapatkan informasi mengenai infection rate schistosomiasis pada keong Oncomelania hupensis lindoensis dan tikus, serta identifikasi tikus sebagai mamalia hospes definitif selain manusia di Bada. Survei dilakukan pada bulan Januari 2015. Pemeriksaan serkaria keong dilakukan dengan metode crushing. Tikus yangdiperoleh diidentifikasi kemudian dibedah untuk memperoleh cacing chistosoma japonicum dan penentuan infection rate pada tikus. Ditemukan tiga keong positif serkaria S.japonicum (infection rate 15%) dari 20 keong yang diperiksa. Diperoleh tiga ekor tikus positif cacing S.japonicum dari 20 perangkap yang dipasang (infection rate 100%). Jenis tikus yang diperoleh adalah Rattus norvegicus, R.argentiventer dan Paruromys dominator. Hasil survei menunjukkan bahwa tingkat infeksi schistosomiasis pada binatang cukup tinggi, sehingga menyebabkan siklus silvatik terus berlangsung

Neurophysiology

Contains research objectives and summary of research.National Institutes of Health (Grant 1 RO1 EY01149-01)National Institutes of Health (Grant 5 P01 GM14940-07)Bell Telephone Laboratories, Inc. (Grant)National Institutes of Health (Grant 5 TO1 GM01555-07)M. I. T. Sloan Fund for Basic Researc

Coordinated effects of sequence variation on DNA binding, chromatin structure, and transcription.

DNA sequence variation has been associated with quantitative changes in molecular phenotypes such as gene expression, but its impact on chromatin states is poorly characterized. To understand the interplay between chromatin and genetic control of gene regulation, we quantified allelic variability in transcription factor binding, histone modifications, and gene expression within humans. We found abundant allelic specificity in chromatin and extensive local, short-range, and long-range allelic coordination among the studied molecular phenotypes. We observed genetic influence on most of these phenotypes, with histone modifications exhibiting strong context-dependent behavior. Our results implicate transcription factors as primary mediators of sequence-specific regulation of gene expression programs, with histone modifications frequently reflecting the primary regulatory event

A quantitative global review of species population monitoring

Abstract: Species monitoring, defined here as the repeated, systematic collection of data to detect long‐term changes in the populations of wild species, is a vital component of conservation practice and policy. We created a database of nearly 1200 schemes, ranging in start date from 1800 to 2018, to review spatial, temporal, taxonomic, and methodological patterns in global species monitoring. We identified monitoring schemes through standardized web searches, an online survey of stakeholders, in‐depth national searches in a sample of countries, and a review of global biodiversity databases. We estimated the total global number of monitoring schemes operating at 3300–15,000. Since 2000, there has been a sharp increase in the number of new schemes being initiated in lower‐ and middle‐income countries and in megadiverse countries, but a decrease in high‐income countries. The total number of monitoring schemes in a country and its per capita gross domestic product were strongly, positively correlated. Schemes that were active in 2018 had been running for an average of 21 years in high‐income countries, compared with 13 years in middle‐income countries and 10 years in low‐income countries. In high‐income countries, over one‐half of monitoring schemes received government funding, but this was less than one‐quarter in low‐income countries. Data collection was undertaken partly or wholly by volunteers in 37% of schemes, and such schemes covered significantly more sites and species than those undertaken by professionals alone. Birds were by far the most widely monitored taxonomic group, accounting for around half of all schemes, but this bias declined over time. Monitoring in most taxonomic groups remains sparse and uncoordinated, and most of the data generated are elusive and unlikely to feed into wider biodiversity conservation processes. These shortcomings could be addressed by, for example, creating an open global meta‐database of biodiversity monitoring schemes and enhancing capacity for species monitoring in countries with high biodiversity. Article impact statement: Species population monitoring for conservation purposes remains strongly biased toward a few vertebrate taxa in wealthier countries

Experimental Studies of Atomic Behavior at Crystal Surfaces

Coordinated Science Laboratory was formerly known as Control Systems LaboratoryJoint Services Electronics Program / DAAB-07-67-C-019