Synthesis and characterization of some vic-dioxime and its mononuclear complexes

WOS: 000247004300007In this study, acetophenone is used as a basis substance. omega-Isonitrosoacetophenone has been synthesized from nitrosyl with amyl nitrite of acetophenone in the presence of sodium ethoxide. Subsequently, anti-phenylglyoxime has been prepared by reacting omega-isonitrosoacetophenone with hydroxylamine and sodium acetate in a ethanolic media. Chlorophenylglyoxime has been obtained from reaction with chlorine gases. Then, three aminophenylglyoxime (ligands) have been prepared by the reaction of chlorophenylglyoxime and the corresponding amines. The Ni(II), Co(II), and Cu(II) complexes with BF2+-bridge of anilinophenylglyoxime and 2,4-dimethylanilinophenylglyoxime were prepared. Then polymeric metal complexes with BF2+-bridge of dopamiophenylglyoxime were prepared. Their structures were identified by FT-IR, H-1 NMR, and ICP-AES spectral data, elemental analysis and magnetic measurements

Synthesis and characterization of some vic-dioxime and its mononuclear complexes (vol 33, pg 351, 2007)

WOS: 000249630300015

Experimental Obstructive Jaundice Results in Oxidized Low-Density-Lipoprotein Accumulation in Surgical Wound of Rats

WOS: 000262975700018PubMed: 19241926Introduction : Mounting evidence suggests that impaired wound heating is a well-defined consequence in obstructive jaundice and, as redox-regulated processes are relevant to wound healing, it is not unreasonable to suppose that oxidative stress associated with lipid peroxidation in cholestasis might be a systemic phenomenon probably comprising all tissues and organs, including wounds. The aim of the present investigation was to analyse the lipid peroxidation status of surgical wounds, in terms of oxidized low-density-lipoprotein (oxLDL) accumulation in experimental obstructive jaundice. Methods : Sixteen Wistar-Albino rats weighing 200-230 gr were randomly divided into two groups. Group I (n = 8) was designed as the prolonged obstructive jaundice group and was subjected to bile duct ligation. Group II (Sham-control, n = 8) rats underwent laparotomy alone and bile duct was just dissected from the surrounding tissue. Histopathological evaluation. immunohistochemical screening and immunoflourescent staining of the surgical wound was conducted to the bile-duct ligated rats and control group on the 21(st) postoperative day. Results : Wound healing was found to be impaired in jaundiced rats histopathologically. When compared with the control group. significant positive oxLDL staining and intracellular accumulation of TNF-alpha, IL-2 and IL-6 was detected ill the wound sections of the prolonged obstructive jaundice group. Conclusion : Our present data is the first in the literature, indicating significant oxLDL accumulation in surgical wounds of cholestatic rats, which might be one of the results of systemic oxidative stress leading to deficient healing capacity as a consequence of persistent inflammation