Investigation of west nile virus infection in brown bears (ursus arctos) in turkey

Aim: This study is a serological and virological examination of the West Nile Virus (WNV) in free-ranging brown bears (Ursus arctos) in Sarikamis district of Kars province of Turkey. Materials and Methods: For this purpose, blood samples from 11 brown bears were tested for antibodies against WNV using a commercial competitive enzyme-linked immunosorbent assay (C-ELISA). Reverse transcription polymerase chain reaction (RT-PCR) technique was used to determine the presence of West Nile Virus nucleic acid. Results: Seropositivity rate was detected to be zero % and West Nile virus nucleic acid was not found in samples. Conclusions: The significance of WNV infection in brown bears and other free-ranging mammals in the Turkey is unknown at this time and will require further investigation. This is the first report of WNV infection in brown bears in Turkey

Plasma nitric oxide levels after injection of therapeutic dose of methylprednisolone acetate in rabbits

Atakisi, Onur/0000-0003-1183-6076WOS: 000268521600009The methylprednisolone asetate (MPA) is an important and long acting member of synthetic glucocorticoids (GC). Although the suppressive effect of GC especially dexamethasone on nitric oxide (NO) synthesis is well known, the effect of MPA on NO production is not fully documented. This study evaluated changes in plasma NO levels before and on day 1, 4 and 7 after injection of two different therapeutic dose of methylprednisolone asetate (MPA; Depo-medrol) in healthy rabbits. The MPA was injected intramuscularly at 2.5 (Group I, n=6) and 5.0 (Group II, n=7) mg/kg doses. Blood samples were collected from auricular vein before and on day 1, 4 and 7 after injections and the NO levels were determined. MPA treatment decreased NO values on day 4 (P<0.001) in both groups. In conclusion, the role of therapeutic dose of long acting MPA administration on the decreased plasma NO levels should be considered by clinicians

Bilious Vomiting Syndrome in a Hunter (Pointer) Dog

Sunulan çalışmada 3.5 yaşlı, erkek Pointer av köpeğinde karşılaşılan “Biliöz Kusma Sendromu” olgusu tartışıldı. Hasta; başlıca efor (av) sonrası gözlenen aralıklı biliöz kusma, diyare, kondüsyon kaybı, titreme ve zayıflama şikayetleri ile Afyon Kocatepe Üniversitesi Veteriner Fakültesi Hayvan Hastanesi’ne başvurmuştur. Hastanın 12 saat açlık sonrası yapılan özafagogastroduedonoskopik muayenesinde midenin boş olduğu gözlendi. Endoskopik muayene sonucu hastada hafif/orta derecede duedonal-gastrik safra refluksu tanımlandı. Uygulanan tedavi prosedürü sonrası şikayetlerin ortadan kalktığı belirlenmiştir.In this study “Bilious Vomiting Syndrome” in a 3.5 year old male Pointher hunting dog was discussed. The patient was referred to the Animal Hospital of Afyon Kocatepe University for the complaints of intermittant bilious vomiting after effort (hunting), diarrhoe, condition lost, tremor and waning. After 12 hours fasting the stomach was determined to be empty by oesophagogastroduedonoscopic examination. According to the endoscopic examination a slight/mild duedonalgastric biliary reflux was observed. It was determined that complaints were disappeared after treatment procedure

The effect of different doses of metamisole sodium on serum enzyme activities and tissue oxidant levels in liver and kidney in mice

WOS: 000258776500002Metamisole sodium (MS), a pyrosilone derivate, is widely used non-opioid analgesic in veterinary medicine. This study evaluated the effect of different doses of metamisole sodium on serum urea, creatin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phophatase (ALP) activities and tissue malondialdehyde (MDA) and reduced glutathione (GSH) level in liver and kidney in mice. The study involved 32 Swiss Albino mice. Animals were divided into four equal groups. One group was left control the other three groups received 20 (Group 1), 50 (Group II) and 100 mg/kg (Group III) MS intramuscularly for 7 days. After a seven-day injection blood and tissue samples were collected from mice. Serum samples were examined for the determination of BUN, creatin, ALT, AST and ALP while tissue samples were evaluated for MDA and GSH levels. The high dose group (100 mg/kg) had higher concentrations of serum BUN, creatin, ALT, AST and tissue MDA but low concentration of GSH (p<0.05) when compared to other groups. In conclusion, short term high dose (100 mg/kg) of MS resulted in liver and kidney degeneration

Bilious Vomiting Syndrome in a Hunter (Pointer) Dog

Sunulan çalışmada 3.5 yaşlı, erkek Pointer av köpeğinde karşılaşılan “Biliöz Kusma Sendromu” olgusu tartışıldı. Hasta; başlıca efor (av) sonrası gözlenen aralıklı biliöz kusma, diyare, kondüsyon kaybı, titreme ve zayıflama şikayetleri ile Afyon Kocatepe Üniversitesi Veteriner Fakültesi Hayvan Hastanesi’ne başvurmuştur. Hastanın 12 saat açlık sonrası yapılan özafagogastroduedonoskopik muayenesinde midenin boş olduğu gözlendi. Endoskopik muayene sonucu hastada hafif/orta derecede duedonal-gastrik safra refluksu tanımlandı. Uygulanan tedavi prosedürü sonrası şikayetlerin ortadan kalktığı belirlenmiştir.In this study “Bilious Vomiting Syndrome” in a 3.5 year old male Pointher hunting dog was discussed. The patient was referred to the Animal Hospital of Afyon Kocatepe University for the complaints of intermittant bilious vomiting after effort (hunting), diarrhoe, condition lost, tremor and waning. After 12 hours fasting the stomach was determined to be empty by oesophagogastroduedonoscopic examination. According to the endoscopic examination a slight/mild duedonalgastric biliary reflux was observed. It was determined that complaints were disappeared after treatment procedure