Is Single Cord Irradiation Going to Be a New Standard for T1a Glottic Carcinoma?

Purpose and Objective:To evaluate the disease-free survival, overall survival, dosimetric, and voice handicap index (VHI) results of T1a glottic invasive squamous cell carcinoma (SCC) patients who underwent hypofractionated single vocal cord irradiation (HSVCI)

Evaluation of Retinal and Optic Disc Vascular Changes and Retinal Nerve Fiber Layer Thickness in Patients with Nasopharyngeal Carcinoma Following Image Guided Intensity-Modulated Radiation Therapy Using Optical Coherence Tomography Angiography

Background: Radiation-induced optic neuropathy (RION) is one of the most important late complications during head and neck radiotherapy and is recognized usually between 2-9 years after RT. Our study aims to prospectively without baseline measurement evaluate retinal and optic disc vascular changes and retinal nerve fiber layer thickness (RNFL) using optical coherence tomography angiography (OCTA) in nasopharyngeal cancer (NPC) patients previously treated with intensity-modulated radiation therapy (IMRT) and with optic nerve doses are above 45 Gy.Methods: Fourteen NPC patients and sixteen age-matched healthy control subjects were included in our study. A complete ophthalmological examination including the best-corrected visual acuity (BCVA), intraocular pressure, slit-lamp biomicroscopic, fundoscopic examination and OCTA were performed for all patients and healthy volunteers. OCTA findings of RT and control groups were compared and correlation analysis was performed to find the association between the radiation-related factors and OCTA findings. Results: Inferior hemi disc, parafovea and perifovea superficial/deep vessel densities were were statistically significantly lower in RT patients. Negative correlations were found between Dmax of optic tract and both RNFL and vessel densities. Furthermore, there were negative correlations found between the Dmean of glob and vessel densities.Conclusion: Although none of the patients in our study had marked vision loss and retinal abnormalities with the examination, OCTA findings showed that perifoveal and parafoveal vascularity were statistically significantly affected due to the RT

Validity and reliability of the Turkish version of DSM-5 Depression Severity Scale-Child Form

Objective: This study aimed to assess the validity and reliability of the Turkish version of DSM-5 Depression Severity Scale-Child Form. Methods: The scale was prepared by carrying out the translation and back-translation of DSM-5 Depression Severity Scale-Child Form. Study group consisted of 46 patients that have been treated in a child psychiatry unit and diagnosed with depressive disorder and 135 healthy volunteers that were attending middle or high school during the study period. For the assessment, Child Depression Inventory (CDI) was used along with DSM-5 Depression Severity Scale-Child Form. Results: Regarding reliability analyses, Cronbach's alpha internal consistency coefficient was calculated as 0.911 while item-total score correlation coefficients were measured between 0.579 and 0.801. As for construct validity, a factor that could explain 59.2% of the variance was obtained and was consistent with the original structure of the scale. In the concurrent validity analysis, the scale showed a high correlation with Child Depression Inventory with a correlation coefficient value measured as r=0.847. Conclusion: It was concluded that Turkish version of DSM-5 Depression Severity Scale-Child Form could be utilized as a valid and reliable tool both in clinical practice and for research purposes