34 research outputs found
Efecto de dosis aguda de alcohol sobre las caracterĂsticas bioquĂmicas del sĂndrome X en distintas categorĂas de bebedores nigerianos hombres y mujeres en aparente buen estado de salud
Background: «Syndrome X», known since the 1980’s is a disease condition precipitated by insulin resistance. Insulin resistance
causes glucose and insulin to accumulate in the blood. Syndrome X is characterized by abnormal values of triacylglycerol (TAG),
blood pressure (BP), glucose and HDL-cholesterol-all risk factors for heart disease. Insulin resistance may be exacerbated by bad
diet, poor lifestyle, absence of physical activity, genetic predisposition and being overweight. However, recent reports have shown
that poor lifestyle is likely to be the main cause rather than bad diet or being overweight. Even though heavy consumption of alcohol
could be regarded as a poor lifestyle, its relationship to the biochemical features and symptoms of syndrome X in both genders
is yet to be properly documented among Nigerian drinkers of alcohol.
Methods: To establish a baseline information on the relationship between alcohol consumption and Syndrome X among
Nigerians, two hundred and seventy-four consenting individuals in apparent good health and who were either light (53 male, 44
female), moderate (51 male, 42 female) or heavy (46 male, 38 female) drinkers of alcohol were selected. They had no personal or familial
history of CHD, stroke, cancer or related diseases. The drinkers were tested using an acute dose (1 g ethanol/kg body weight) of
alcohol.
Results: Results show that the administered acute dose (1 g ethanol/kg body weight) increased serum glucose, (p>0.05), TAG
(p<0.05) and BP (p<0.05) (some biochemical risk factors of Syndrome X) in both genders irrespective of the drinking category.
However, alcohol-induced changes were highest among the female heavy drinkers. Thus, observations from this study suggest
that heavy consumption of alcohol by especially the female folk could alter the pathways that metabolize carbohydrates and lipids
and this may increase the risk of Syndrome X.
Conclusions: Based on the available evidence, it would be reasonable to conclude that heavy consumption of alcohol by
Nigerian women especially may be yet another predisposing lifestyle to Syndrome X. The incidence of Syndrome X among drinkers
of alcohol should be further investigated in order to provide clues to the underlying molecular mechanisms. This is important in
order to strategize therapeutic approaches, since individuals with the disease may not recognize it. Antecedentes: Desde la dĂ©cada de 1980 se conoce el sĂndrome X, entidad patolĂłgica que se precipita por la resistencia a la
insulina. A su turno, esta resistencia hace que la glucosa y la insulina se acumulen en la sangre. El sĂndrome X se caracteriza por
valores anormales de triacilglicerol (TAG), presiĂłn sanguĂnea (PS), glucosa y colesterol de alta densidad (HDL), que son todos
elementos de riesgo para enfermedades cardĂacas. La resistencia a la insulina se puede aumentar por malos hábitos dietĂ©ticos, falta
de actividad fĂsica, predisposiciĂłn genĂ©tica y sobrepeso. Sin embargo, varios informes recientes demostraron que un estilo de vida
poco saludable puede ser tambiĂ©n una causa principal del sĂndrome, quizá más que los malos hábitos dietĂ©ticos o el sobrepeso.
Aunque el consumo alto de alcohol se podrĂa considerar como un estilo de vida poco saludable, su relaciĂłn con los factores
bioquĂmicos y los sĂntomas del sĂndrome X, en ambos gĂ©neros, aĂşn no se ha documentado de manera precisa entre los nigerianos consumidores de alcohol.
MĂ©todos: Establecer una informaciĂłn de base acerca de las
relaciones entre consumo de alcohol y sĂndrome X para 264
nigerianos en aparente buen estado de salud que participaron
de modo voluntario en el estudio. Aunque todos consumĂan
alcohol, entre ellos habĂa consumidores ligeros (53 hombres, 44
mujeres); consumidores moderados (51 hombres, 42 mujeres);
y consumidores pesados (46 hombres, 38 mujeres). Ninguno
tenĂa historia familiar de enfermedad cardĂaca coronaria (ECC),
accidentes cerebro-vasculares, cáncer, y otras enfermedades
relacionadas. A todos se les examinĂł con una dosis de prueba
(1 g de etanol/kg peso corporal) de alcohol.
Resultados: Se comprobĂł que la dosis de prueba administrada
(1 g de etanol/kg peso corporal) aumentĂł los niveles
sanguĂneos de glucosa (p>0.05) y TAG (p<0.05), asĂ como la PS
(p<0.05), factores de riesgo para el SĂndrome X en ambos
gĂ©neros, sin tener en cuenta la categorĂa del consumidor. Sin
embargo, los cambios inducidos por el alcohol fueron más altos
en las mujeres de consumo pesado. AsĂ, pues, las observaciones
de este estudio sugieren que el consumo alto de alcohol, sobre
todo en las mujeres, puede alterar las vĂas del metabolismo de
carbohidratos y lĂpidos y de esta manera aumentar el riesgo del
sĂndrome X.
Conclusiones: Con base en la evidencia disponible, es
razonable concluir que el consumo elevado de alcohol especialmente
en las mujeres nigerianas puede ser otro estilo de vida
poco saludable que predispone al sĂndrome X. La incidencia del
sĂndrome X entre los consumidores de alcohol se deberĂa
investigar más a fin de suministrar sugerencias e indicios acerca
de los mecanismos moleculares subyacentes. Esto es importante
para diseñar estrategias en los manejos terapéuticos, pues los
individuos con la enfermedad no la pueden reconocer
Changes in some haematological parameters in Nigeria children with Burkitt's lymphoma
In order to investigate the prevalence of anaemia and related haematological disorders, fifty-seven Nigerian children with Burkitt's Lymphoma, (BL) between the ages of 4-14 years were randomly selected from the paediatric Ward, Ahmadu Bello University Teaching Hospital, Zaria and Kaduna. Twenty-eight age-matched children in apparent good health were included as control subjects. Results show that BL patients had significant (
Changes in some haematological parameters in Nigeria children with Burkitt's lymphoma
In order to investigate the prevalence of anaemia and related
haematological disorders, fifty-seven Nigerian children with Burkitt's
Lymphoma, (BL) between the ages of 4-14 years were randomly selected
from the paediatric Ward, Ahmadu Bello University Teaching Hospital,
Zaria and Kaduna. Twenty-eight age-matched children in apparent good
health were included as control subjects. Results show that BL patients
had significant (p<0.05) reduction in haemoglobin content compared
to control values. Differential white blood cell (WBC) counts were not
significantly different in the values for neutrophils and lymphocytes,
when compared with control values, but the eosinophil count was
significantly (p<0.05) different when compared with values obtained
from the control subjects. Evidence available from the data of this
investigation suggest that some Nigerian children with BL had mild to
moderate anaemia and higher eosinophilic response during the course of
BL pathogenesis. Thus, any plan to treat BL patients should recognize
these conditions
Assessment of the impact of abattoir activities on the physicochemical properties of soils within a residential area of Omu-Aran, Nigeria
Waste effluents from abattoirs have been documented to have harmful effects on the
soil media. There is little information about the level of contamination by abattoir effluents on
the soil media in Omu-Aran. This study therefore assessed soil samples for possible
contamination of physicochemical parameters and heavy metals from different points and some
meters away from the mini abattoir in Omu-Aran, Kwara State, Nigeria. Soil samples which are
18 in number were collected from the soil around wells which are owned by individuals and a
well designated as Control situated at distances which vary and different elevations to the
abattoir. The physicochemical parameters of the soil samples were obtained by applying the
standard methods. The analysis of data was achieved using descriptive statistics and ANOVA.
The mean values of parameters in the soil samples collected around the studied wells ranged
from 31.00±2.00–110.03±8.72 mg/L and 7.21±0.02–7.83±0.02 for electrical conductivity and
pH respectively. Chloride, nitrate and phosphate had values of 6.37±0.13–9.13±0.21 mg/L,
3.67±0.07–4.50±0.31 mg/L and 3.86±0.07–5.41±0.30 mg/L respectively. However, average
values for heavy metals (Ni, Cr and Pb) though slightly higher than the control site, were above
permissible limits. Activities within Omu-Aran Abattoir impacts negatively on the surrounding
arable soils; therefore, pollution control procedures which are sustainable should be
implemented for abattoirs situated in residential area
The TH1/TH2 balance in clinical course of burkitt's lymphoma
No Abstract.Global Journal of Pure and Applied Sciences Vol. 13 (3) 2007: pp.411-41
Intestinal Obstruction due to Bilateral Ovarian Cystic Teratoma in a Pregnant Woman: Report of a Case
Teratoma is the most common ovarian tumour associated with pregnancy. The complications in pregnancy include torsion, rupture and malignant transformation mimicking ovarian carcinoma. Its association with intestinal obstruction is uncommon. Case: A 35 year old gravida 5 para 4 woman with 18 week gestation was referred to our hospital with a 2 week history of abdominal pain, abdominal distension and vomiting. Initial physical examination and ultrasound scan showed bilateral ovarian masses andintrauterine singleton viable pregnancy. At surgery the right mass was observed to be adherent to a part of the small intestine. The masses were excised and confirmed grossly and histologically as benign cystic teratoma. She was well and discharged nine days post operatively. The pregnancy was managed conservatively and she was delivered of a normal male baby at term by spontaneous vertex delivery. Although intestinal obstruction due to benign cystic teratoma in pregnancy is uncommon, abrupt surgical intervention and conservative management is important for favourable outcome (Afr J Reprod Health 2011; 15[1]: 115-118)
Modelling emissions from natural gas flaring
The world today recognizes the significance of environmental sustainability to the development of nations. Hence, the role oil and gas industry plays in environmental degrading activities such as gas flaring is of global concern. This study presents material balance equations and predicts results for non-hydrocarbon emissions such as CO2, CO, NO, NO2, and SO2 etc. from flaring (combustion) of 12 natural gas samples representing composition of natural gas of global origin. Gaseous emission estimates and pattern were modelled by coding material balance equations for six reaction types and combustion conditions with a computer program. On the average, anticipated gaseous emissions from flaring natural gas with an average annual global flaring rate 126Â bcm per year (between 2000 and 2011) in million metric tonnes (mmt) are 560Â mmt, 48Â mmt, 91Â mmt, 93Â mmt and 50Â mmt for CO2, CO, NO, NO2 and SO2 respectively. This model predicted gaseous emissions based on the possible individual combustion types and conditions anticipated in gas flaring operation. It will assist in the effort by environmental agencies and all concerned to track and measure the extent of environmental pollution caused by gas flaring operations in the oil and gas industry
Evaluation of the immune function in HIV/AIDS patients using migration inhibition factor (M/F) test
Several mechanisms have been described regarding HIV/AIDS immunopathogenesis. Some are related to the humoral response and others to the cellular immune response. Migration inhibition factor (MIF) test is one of the in-vitro methods used in monitoring the cell-mediated immunity of delayed type hypersensitivity (DTH). This study monitored MIF level in symptomatic HIV seropositive AIDS patients (n=50) and asymptomatic HIV seropositive patients (n-40); HIV seronegetive (n=40) were included as control subjects. The various MIF percentage values for the HIV seropositive (symptomatic: 110.86 ± 14.97%; asymptomatic: 91.22±14.62%) groups were significantly higher (p‹0.05) than the control group (64.68±13.20%). This suggests that the cellular immune function in HIV seropositive and AIDS patient is highly compromised.
Global Journal of Mathematical Sciences Vol. 6 (1) 2007: pp. 5-
Modelling combustion reactions for gas flaring and its resulting emissions
AbstractFlaring of associated petroleum gas is an age long environmental concern which remains unabated. Flaring of gas maybe a very efficient combustion process especially steam/air assisted flare and more economical than utilization in some oil fields. However, it has serious implications for the environment. This study considered different reaction types and operating conditions for gas flaring. Six combustion equations were generated using the mass balance concept with varying air and combustion efficiency. These equations were coded with a computer program using 12 natural gas samples of different chemical composition and origin to predict the pattern of emission species from gas flaring. The effect of key parameters on the emission output is also shown. CO2, CO, NO, NO2 and SO2 are the anticipated non-hydrocarbon emissions of environmental concern. Results show that the quantity and pattern of these chemical species depended on percentage excess/deficiency of stoichiometric air, natural gas type, reaction type, carbon mass content, impurities, combustion efficiency of the flare system etc. These emissions degrade the environment and human life, so knowing the emission types, pattern and flaring conditions that this study predicts is of paramount importance to governments, environmental agencies and the oil and gas industry
Efecto de dosis aguda de alcohol sobre las caracterĂsticas bioquĂmicas del sĂndrome X en distintas categorĂas de bebedores nigerianos hombres y mujeres en aparente buen estado de salud
Background: «Syndrome X», known since the 1980's is a disease
condition precipitated by insulin resistance. Insulin resistance causes
glucose and insulin to accumulate in the blood. Syndrome X is
characterized by abnormal values of triacylglycerol (TAG), blood
pressure (BP), glucose and HDL-cholesterol-all risk factors for heart
disease. Insulin resistance may be exacerbated by bad diet, poor
lifestyle, absence of physical activity, genetic predisposition and
being overweight. However, recent reports have shown that poor
lifestyle is likely to be the main cause rather than bad diet or being
overweight. Even though heavy consumption of alcohol could be regarded
as a poor lifestyle, its relationship to the biochemical features and
symptoms of Syndrome X in both genders is yet to be properly documented
among Nigerian drinkers of alcohol. Methods: To establish a baseline
information on the relationship between alcohol consumption and
Syndrome X among Nigerians, two hundred and seventy-four consenting
individuals in apparent good health and who were either light (53 male,
44 female), moderate (51 male, 42 female) or heavy (46 male, 38 female)
drinkers of alcohol were selected. They had no personal or familial
history of CHD, stroke, cancer or related diseases. The drinkers were
tested using an acute dose (1 g ethanol/kg body weight) of alcohol.
Results: Results show that the administered acute dose (1 g ethanol/kg
body weight) increased serum glucose, (p>0.05), TAG (p<0.05) and
BP (p<0.05) some biochemical risk factors of Syndrome X in both
genders irrespective of the drinking category. However, alcohol-induced
changes were highest among the female heavy drinkers. Thus,
observations from this study suggest that heavy consumption of alcohol
by especially the female folk could alter the pathways that metabolize
carbohydrates and lipids and this may increase the risk of Syndrome X.
Conclusions: Based on the available evidence, it would be reasonable to
conclude that heavy consumption of alcohol by Nigerian women especially
may be yet another predisposing lifestyle to Syndrome X. The incidence
of Syndrome X among drinkers of alcohol should be further investigated
in order to provide clues to the underlying molecular mechanisms. This
is important in order to strategize therapeutic approaches, since
individuals with the disease may not recognize it.Antecedentes: Desde la dĂ©cada de 1980 se conoce el sĂndrome
X, entidad patolĂłgica que se precipita por la resistencia a la
insulina. A su turno, esta resistencia hace que la glucosa y la
insulina se acumulen en la sangre. El sĂndrome X se caracteriza
por valores anormales de triacilglicerol (TAG), presiĂłn
sanguĂnea (PS), glucosa y colesterol de alta densidad (HDL), que
son todos elementos de riesgo para enfermedades cardĂacas. La
resistencia a la insulina se puede aumentar por malos hábitos
dietĂ©ticos, falta de actividad fĂsica, predisposiciĂłn
genética y sobrepeso. Sin embargo, varios informes recientes
demostraron que un estilo de vida poco saludable puede ser también
una causa principal del sĂndrome, quizá más que los
malos hábitos dietéticos o el sobrepeso. Aunque el consumo
alto de alcohol se podrĂa considerar como un estilo de vida poco
saludable, su relaciĂłn con los factores bioquĂmicos y los
sĂntomas del sĂndrome X, en ambos gĂ©neros, aĂşn no
se ha documentado de manera precisa entre los nigerianos consumidores
de alcohol. MĂ©todos: Establecer una informaciĂłn de base
acerca de las relaciones entre consumo de alcohol y sĂndrome X
para 264 nigerianos en aparente buen estado de salud que participaron
de modo voluntario en el estudio. Aunque todos consumĂan alcohol,
entre ellos habĂa consumidores ligeros (53 hombres, 44 mujeres);
consumidores moderados (51 hombres, 42 mujeres); y consumidores pesados
(46 hombres, 38 mujeres). Ninguno tenĂa historia familiar de
enfermedad cardĂaca coronaria (ECC), accidentes
cerebro-vasculares, cáncer, y otras enfermedades relacionadas. A
todos se les examinĂł con una dosis de prueba (1 g de etanol/kg
peso corporal) de alcohol. Resultados: Se comprobĂł que la dosis de
prueba administrada (1 g de etanol/kg peso corporal) aumentĂł los
niveles sanguĂneos de glucosa (p>0.05) y TAG (p<0.05),
asĂ como la PS (p<0.05), factores de riesgo para el
SĂndrome X en ambos gĂ©neros, sin tener en cuenta la
categorĂa del consumidor. Sin embargo, los cambios inducidos por
el alcohol fueron más altos en las mujeres de consumo pesado.
AsĂ, pues, las observaciones de este estudio sugieren que el
consumo alto de alcohol, sobre todo en las mujeres, puede alterar las
vĂas del metabolismo de carbohidratos y lĂpidos y de esta
manera aumentar el riesgo del sĂndrome X. Conclusiones: Con base
en la evidencia disponible, es razonable concluir que el consumo
elevado de alcohol especialmente en las mujeres nigerianas puede ser
otro estilo de vida poco saludable que predispone al sĂndrome X.
La incidencia del sĂndrome X entre los consumidores de alcohol se
deberĂa investigar más a fin de suministrar sugerencias e
indicios acerca de los mecanismos moleculares subyacentes. Esto es
importante para diseñar estrategias en los manejos
terapéuticos, pues los individuos con la enfermedad no la pueden
reconocer